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Gene: CRIM1 |
Gene summary for CRIM1 |
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Gene information | Species | Human | Gene symbol | CRIM1 | Gene ID | 51232 |
Gene name | cysteine rich transmembrane BMP regulator 1 | |
Gene Alias | CRIM-1 | |
Cytomap | 2p22.2 | |
Gene Type | protein-coding | GO ID | GO:0001503 | UniProtAcc | Q9NZV1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51232 | CRIM1 | N_HPV_1 | Human | Cervix | N_HPV | 6.07e-03 | -1.60e-01 | 0.0079 |
51232 | CRIM1 | CCI_2 | Human | Cervix | CC | 2.08e-07 | 1.05e+00 | 0.5249 |
51232 | CRIM1 | Tumor | Human | Cervix | CC | 2.07e-03 | -1.87e-01 | 0.1241 |
51232 | CRIM1 | L1 | Human | Cervix | CC | 2.80e-02 | -2.18e-01 | 0.0802 |
51232 | CRIM1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.43e-30 | -8.33e-01 | 0.0155 |
51232 | CRIM1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 4.89e-13 | -6.58e-01 | -0.1808 |
51232 | CRIM1 | HTA11_2951_2000001011 | Human | Colorectum | AD | 4.47e-05 | -8.38e-01 | 0.0216 |
51232 | CRIM1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.52e-02 | -4.71e-01 | -0.0811 |
51232 | CRIM1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.35e-17 | -8.80e-01 | -0.1207 |
51232 | CRIM1 | HTA11_83_2000001011 | Human | Colorectum | SER | 1.93e-06 | -6.18e-01 | -0.1526 |
51232 | CRIM1 | HTA11_696_2000001011 | Human | Colorectum | AD | 9.80e-28 | -6.72e-01 | -0.1464 |
51232 | CRIM1 | HTA11_866_2000001011 | Human | Colorectum | AD | 3.47e-10 | -5.07e-01 | -0.1001 |
51232 | CRIM1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.30e-14 | -6.78e-01 | -0.059 |
51232 | CRIM1 | HTA11_2992_2000001011 | Human | Colorectum | SER | 1.40e-02 | -6.38e-01 | -0.1706 |
51232 | CRIM1 | HTA11_5216_2000001011 | Human | Colorectum | SER | 7.38e-03 | -7.24e-01 | -0.1462 |
51232 | CRIM1 | HTA11_546_2000001011 | Human | Colorectum | AD | 1.87e-02 | -5.29e-01 | -0.0842 |
51232 | CRIM1 | HTA11_9341_2000001011 | Human | Colorectum | SER | 3.42e-03 | -8.85e-01 | -0.00410000000000005 |
51232 | CRIM1 | HTA11_866_3004761011 | Human | Colorectum | AD | 4.33e-22 | -7.20e-01 | 0.096 |
51232 | CRIM1 | HTA11_4255_2000001011 | Human | Colorectum | SER | 4.98e-02 | -7.24e-01 | 0.0446 |
51232 | CRIM1 | HTA11_9408_2000001011 | Human | Colorectum | AD | 5.06e-03 | -8.62e-01 | 0.0451 |
Page: 1 2 3 4 5 6 7 8 9 10 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:005254710 | Cervix | CC | regulation of peptidase activity | 112/2311 | 461/18723 | 6.70e-13 | 3.08e-10 | 112 |
GO:005254810 | Cervix | CC | regulation of endopeptidase activity | 103/2311 | 432/18723 | 1.89e-11 | 5.14e-09 | 103 |
GO:004586110 | Cervix | CC | negative regulation of proteolysis | 80/2311 | 351/18723 | 2.88e-08 | 1.98e-06 | 80 |
GO:00513469 | Cervix | CC | negative regulation of hydrolase activity | 81/2311 | 379/18723 | 4.27e-07 | 1.67e-05 | 81 |
GO:00104669 | Cervix | CC | negative regulation of peptidase activity | 60/2311 | 262/18723 | 1.27e-06 | 4.34e-05 | 60 |
GO:001095110 | Cervix | CC | negative regulation of endopeptidase activity | 56/2311 | 252/18723 | 7.43e-06 | 1.74e-04 | 56 |
GO:00071786 | Cervix | CC | transmembrane receptor protein serine/threonine kinase signaling pathway | 67/2311 | 355/18723 | 2.39e-04 | 2.67e-03 | 67 |
GO:00016497 | Cervix | CC | osteoblast differentiation | 47/2311 | 229/18723 | 2.88e-04 | 3.11e-03 | 47 |
GO:0045667 | Cervix | CC | regulation of osteoblast differentiation | 29/2311 | 132/18723 | 1.32e-03 | 1.05e-02 | 29 |
GO:00015037 | Cervix | CC | ossification | 71/2311 | 408/18723 | 1.67e-03 | 1.28e-02 | 71 |
GO:005254824 | Cervix | N_HPV | regulation of endopeptidase activity | 36/534 | 432/18723 | 9.74e-09 | 1.72e-06 | 36 |
GO:005254724 | Cervix | N_HPV | regulation of peptidase activity | 36/534 | 461/18723 | 5.15e-08 | 5.59e-06 | 36 |
GO:004586124 | Cervix | N_HPV | negative regulation of proteolysis | 27/534 | 351/18723 | 3.27e-06 | 1.36e-04 | 27 |
GO:001095123 | Cervix | N_HPV | negative regulation of endopeptidase activity | 21/534 | 252/18723 | 1.21e-05 | 4.05e-04 | 21 |
GO:001046623 | Cervix | N_HPV | negative regulation of peptidase activity | 21/534 | 262/18723 | 2.18e-05 | 6.16e-04 | 21 |
GO:005134624 | Cervix | N_HPV | negative regulation of hydrolase activity | 25/534 | 379/18723 | 9.66e-05 | 1.97e-03 | 25 |
GO:000717821 | Cervix | N_HPV | transmembrane receptor protein serine/threonine kinase signaling pathway | 22/534 | 355/18723 | 5.85e-04 | 7.73e-03 | 22 |
GO:000164913 | Cervix | N_HPV | osteoblast differentiation | 14/534 | 229/18723 | 6.22e-03 | 4.28e-02 | 14 |
GO:000150312 | Cervix | N_HPV | ossification | 21/534 | 408/18723 | 6.98e-03 | 4.61e-02 | 21 |
GO:0052547 | Colorectum | AD | regulation of peptidase activity | 137/3918 | 461/18723 | 4.12e-06 | 1.12e-04 | 137 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CRIM1 | SNV | Missense_Mutation | novel | c.1330N>G | p.Asn444Asp | p.N444D | Q9NZV1 | protein_coding | deleterious(0.02) | benign(0.119) | TCGA-DI-A1BU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
CRIM1 | SNV | Missense_Mutation | novel | c.2056N>A | p.Tyr686Asn | p.Y686N | Q9NZV1 | protein_coding | deleterious(0.01) | probably_damaging(0.981) | TCGA-DI-A1BU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
CRIM1 | SNV | Missense_Mutation | novel | c.2652N>G | p.Ile884Met | p.I884M | Q9NZV1 | protein_coding | tolerated(0.06) | benign(0.278) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CRIM1 | SNV | Missense_Mutation | novel | c.1571N>T | p.Ala524Val | p.A524V | Q9NZV1 | protein_coding | tolerated(0.3) | benign(0.003) | TCGA-EY-A548-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CRIM1 | SNV | Missense_Mutation | novel | c.1082N>T | p.Gly361Val | p.G361V | Q9NZV1 | protein_coding | deleterious(0) | probably_damaging(0.963) | TCGA-FI-A2F4-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CRIM1 | insertion | Frame_Shift_Ins | novel | c.1574_1575insTTTACATT | p.Gln525HisfsTer4 | p.Q525Hfs*4 | Q9NZV1 | protein_coding | TCGA-BG-A0MS-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD | ||
CRIM1 | SNV | Missense_Mutation | c.1688N>A | p.Arg563His | p.R563H | Q9NZV1 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-G3-A3CH-01 | Liver | liver hepatocellular carcinoma | Male | <65 | III/IV | Targeted Molecular therapy | sorafenib | SD | |
CRIM1 | SNV | Missense_Mutation | c.1348N>T | p.Gly450Trp | p.G450W | Q9NZV1 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-05-4395-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
CRIM1 | SNV | Missense_Mutation | novel | c.2897N>T | p.Trp966Leu | p.W966L | Q9NZV1 | protein_coding | tolerated(0.05) | probably_damaging(0.986) | TCGA-05-4396-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
CRIM1 | SNV | Missense_Mutation | novel | c.760G>T | p.Asp254Tyr | p.D254Y | Q9NZV1 | protein_coding | deleterious(0) | probably_damaging(0.97) | TCGA-38-4631-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
Page: 1 2 3 4 5 6 7 8 9 10 11 |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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