|
Gene: COL14A1 |
Gene summary for COL14A1 |
Gene summary. |
Gene information | Species | Human | Gene symbol | COL14A1 | Gene ID | 7373 |
Gene name | collagen type XIV alpha 1 chain | |
Gene Alias | UND | |
Cytomap | 8q24.12 | |
Gene Type | protein-coding | GO ID | GO:0007155 | UniProtAcc | Q05707 |
Top |
Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7373 | COL14A1 | cirrhotic3 | Human | Liver | Cirrhotic | 2.03e-08 | 3.31e-01 | 0.0215 |
7373 | COL14A1 | S014 | Human | Liver | HCC | 5.03e-06 | 5.23e-01 | 0.2254 |
7373 | COL14A1 | S015 | Human | Liver | HCC | 5.36e-09 | 7.74e-01 | 0.2375 |
7373 | COL14A1 | S016 | Human | Liver | HCC | 1.65e-04 | 5.45e-01 | 0.2243 |
7373 | COL14A1 | male-WTA | Human | Thyroid | PTC | 3.17e-68 | 8.45e-01 | 0.1037 |
7373 | COL14A1 | PTC01 | Human | Thyroid | PTC | 3.72e-16 | 3.45e-01 | 0.1899 |
7373 | COL14A1 | PTC04 | Human | Thyroid | PTC | 5.58e-09 | 6.32e-01 | 0.1927 |
7373 | COL14A1 | PTC05 | Human | Thyroid | PTC | 4.83e-07 | 7.27e-01 | 0.2065 |
7373 | COL14A1 | PTC06 | Human | Thyroid | PTC | 2.55e-51 | 1.96e+00 | 0.2057 |
7373 | COL14A1 | PTC07 | Human | Thyroid | PTC | 5.48e-60 | 1.32e+00 | 0.2044 |
7373 | COL14A1 | ATC13 | Human | Thyroid | ATC | 2.50e-70 | 2.60e+00 | 0.34 |
7373 | COL14A1 | ATC5 | Human | Thyroid | ATC | 4.04e-84 | 2.74e+00 | 0.34 |
Page: 1 |
Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00301986 | Thyroid | PTC | extracellular matrix organization | 124/5968 | 301/18723 | 3.75e-04 | 2.53e-03 | 124 |
GO:00430626 | Thyroid | PTC | extracellular structure organization | 124/5968 | 302/18723 | 4.38e-04 | 2.92e-03 | 124 |
GO:00452296 | Thyroid | PTC | external encapsulating structure organization | 124/5968 | 304/18723 | 5.96e-04 | 3.79e-03 | 124 |
GO:00301995 | Thyroid | PTC | collagen fibril organization | 29/5968 | 61/18723 | 7.57e-03 | 3.23e-02 | 29 |
GO:003019812 | Thyroid | ATC | extracellular matrix organization | 152/6293 | 301/18723 | 8.63e-10 | 2.24e-08 | 152 |
GO:004306212 | Thyroid | ATC | extracellular structure organization | 152/6293 | 302/18723 | 1.17e-09 | 2.94e-08 | 152 |
GO:004522912 | Thyroid | ATC | external encapsulating structure organization | 152/6293 | 304/18723 | 2.11e-09 | 5.08e-08 | 152 |
GO:003019911 | Thyroid | ATC | collagen fibril organization | 43/6293 | 61/18723 | 4.24e-09 | 9.57e-08 | 43 |
Page: 1 |
Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
COL14A1 | SNV | Missense_Mutation | c.4702C>T | p.Pro1568Ser | p.P1568S | Q05707 | protein_coding | tolerated(0.13) | possibly_damaging(0.809) | TCGA-AD-6895-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
COL14A1 | SNV | Missense_Mutation | c.2990C>A | p.Pro997His | p.P997H | Q05707 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-AM-5821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
COL14A1 | SNV | Missense_Mutation | novel | c.1794N>T | p.Glu598Asp | p.E598D | Q05707 | protein_coding | tolerated(0.3) | benign(0.005) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
COL14A1 | SNV | Missense_Mutation | novel | c.3955N>T | p.Val1319Phe | p.V1319F | Q05707 | protein_coding | deleterious(0) | benign(0.053) | TCGA-AZ-6599-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
COL14A1 | SNV | Missense_Mutation | rs759810359 | c.955G>A | p.Glu319Lys | p.E319K | Q05707 | protein_coding | deleterious(0.01) | benign(0.43) | TCGA-AZ-6608-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
COL14A1 | SNV | Missense_Mutation | rs750355331 | c.587N>A | p.Arg196Gln | p.R196Q | Q05707 | protein_coding | tolerated(0.98) | probably_damaging(0.998) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
COL14A1 | SNV | Missense_Mutation | rs115448007 | c.4033N>A | p.Glu1345Lys | p.E1345K | Q05707 | protein_coding | deleterious(0.04) | benign(0.235) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
COL14A1 | SNV | Missense_Mutation | c.1697N>A | p.Arg566Gln | p.R566Q | Q05707 | protein_coding | deleterious(0.02) | possibly_damaging(0.834) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
COL14A1 | SNV | Missense_Mutation | c.4251G>A | p.Met1417Ile | p.M1417I | Q05707 | protein_coding | tolerated(0.13) | benign(0.01) | TCGA-CM-5861-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
COL14A1 | SNV | Missense_Mutation | rs762064528 | c.4949N>A | p.Arg1650Gln | p.R1650Q | Q05707 | protein_coding | deleterious(0.03) | possibly_damaging(0.528) | TCGA-CM-6674-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 |
Top |
Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |