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Gene: COG3 |
Gene summary for COG3 |
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Gene information | Species | Human | Gene symbol | COG3 | Gene ID | 83548 |
Gene name | component of oligomeric golgi complex 3 | |
Gene Alias | SEC34 | |
Cytomap | 13q14.13 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | Q96JB2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
83548 | COG3 | LZE4T | Human | Esophagus | ESCC | 1.73e-05 | 1.45e-01 | 0.0811 |
83548 | COG3 | LZE5T | Human | Esophagus | ESCC | 6.44e-04 | 3.59e-01 | 0.0514 |
83548 | COG3 | LZE8T | Human | Esophagus | ESCC | 1.07e-02 | 6.04e-02 | 0.067 |
83548 | COG3 | LZE24T | Human | Esophagus | ESCC | 1.23e-03 | 1.78e-01 | 0.0596 |
83548 | COG3 | P1T-E | Human | Esophagus | ESCC | 3.60e-08 | 3.72e-01 | 0.0875 |
83548 | COG3 | P2T-E | Human | Esophagus | ESCC | 4.59e-13 | 1.05e-01 | 0.1177 |
83548 | COG3 | P4T-E | Human | Esophagus | ESCC | 4.84e-03 | 4.98e-02 | 0.1323 |
83548 | COG3 | P5T-E | Human | Esophagus | ESCC | 7.03e-16 | 6.84e-02 | 0.1327 |
83548 | COG3 | P8T-E | Human | Esophagus | ESCC | 1.41e-18 | 2.85e-01 | 0.0889 |
83548 | COG3 | P9T-E | Human | Esophagus | ESCC | 2.73e-08 | 1.53e-01 | 0.1131 |
83548 | COG3 | P10T-E | Human | Esophagus | ESCC | 3.84e-08 | 2.87e-01 | 0.116 |
83548 | COG3 | P11T-E | Human | Esophagus | ESCC | 8.19e-03 | 2.29e-01 | 0.1426 |
83548 | COG3 | P12T-E | Human | Esophagus | ESCC | 5.55e-05 | 1.46e-02 | 0.1122 |
83548 | COG3 | P15T-E | Human | Esophagus | ESCC | 4.61e-20 | 2.99e-01 | 0.1149 |
83548 | COG3 | P16T-E | Human | Esophagus | ESCC | 2.06e-12 | 2.13e-01 | 0.1153 |
83548 | COG3 | P17T-E | Human | Esophagus | ESCC | 1.30e-02 | 1.62e-01 | 0.1278 |
83548 | COG3 | P20T-E | Human | Esophagus | ESCC | 7.42e-06 | 1.84e-01 | 0.1124 |
83548 | COG3 | P21T-E | Human | Esophagus | ESCC | 8.59e-09 | 2.01e-01 | 0.1617 |
83548 | COG3 | P22T-E | Human | Esophagus | ESCC | 1.74e-06 | 1.15e-01 | 0.1236 |
83548 | COG3 | P23T-E | Human | Esophagus | ESCC | 2.81e-11 | 2.43e-01 | 0.108 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004819318 | Esophagus | ESCC | Golgi vesicle transport | 231/8552 | 296/18723 | 1.82e-30 | 9.63e-28 | 231 |
GO:0031647111 | Esophagus | ESCC | regulation of protein stability | 223/8552 | 298/18723 | 5.76e-25 | 1.52e-22 | 223 |
GO:0050821111 | Esophagus | ESCC | protein stabilization | 140/8552 | 191/18723 | 6.50e-15 | 3.61e-13 | 140 |
GO:000688815 | Esophagus | ESCC | endoplasmic reticulum to Golgi vesicle-mediated transport | 102/8552 | 130/18723 | 1.73e-14 | 9.22e-13 | 102 |
GO:000689017 | Esophagus | ESCC | retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum | 46/8552 | 52/18723 | 1.23e-10 | 3.66e-09 | 46 |
GO:00091002 | Esophagus | ESCC | glycoprotein metabolic process | 226/8552 | 387/18723 | 2.64e-07 | 3.94e-06 | 226 |
GO:00070308 | Esophagus | ESCC | Golgi organization | 101/8552 | 157/18723 | 1.78e-06 | 2.10e-05 | 101 |
GO:00700854 | Esophagus | ESCC | glycosylation | 144/8552 | 240/18723 | 5.12e-06 | 5.38e-05 | 144 |
GO:00064865 | Esophagus | ESCC | protein glycosylation | 135/8552 | 226/18723 | 1.36e-05 | 1.24e-04 | 135 |
GO:00434135 | Esophagus | ESCC | macromolecule glycosylation | 135/8552 | 226/18723 | 1.36e-05 | 1.24e-04 | 135 |
GO:00091012 | Esophagus | ESCC | glycoprotein biosynthetic process | 181/8552 | 317/18723 | 2.54e-05 | 2.15e-04 | 181 |
GO:00068914 | Esophagus | ESCC | intra-Golgi vesicle-mediated transport | 26/8552 | 33/18723 | 1.06e-04 | 7.43e-04 | 26 |
GO:00481936 | Liver | NAFLD | Golgi vesicle transport | 66/1882 | 296/18723 | 3.66e-10 | 9.30e-08 | 66 |
GO:00316477 | Liver | NAFLD | regulation of protein stability | 61/1882 | 298/18723 | 5.00e-08 | 4.71e-06 | 61 |
GO:0007030 | Liver | NAFLD | Golgi organization | 36/1882 | 157/18723 | 1.76e-06 | 7.68e-05 | 36 |
GO:00508217 | Liver | NAFLD | protein stabilization | 40/1882 | 191/18723 | 5.38e-06 | 1.95e-04 | 40 |
GO:00068885 | Liver | NAFLD | endoplasmic reticulum to Golgi vesicle-mediated transport | 26/1882 | 130/18723 | 4.78e-04 | 6.78e-03 | 26 |
GO:004819321 | Liver | HCC | Golgi vesicle transport | 217/7958 | 296/18723 | 2.58e-27 | 1.02e-24 | 217 |
GO:003164722 | Liver | HCC | regulation of protein stability | 211/7958 | 298/18723 | 2.29e-23 | 5.01e-21 | 211 |
GO:005082122 | Liver | HCC | protein stabilization | 139/7958 | 191/18723 | 1.61e-17 | 1.71e-15 | 139 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
COG3 | SNV | Missense_Mutation | c.1283G>A | p.Gly428Glu | p.G428E | Q96JB2 | protein_coding | tolerated(0.11) | benign(0.162) | TCGA-37-4141-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
COG3 | SNV | Missense_Mutation | c.1776A>T | p.Leu592Phe | p.L592F | Q96JB2 | protein_coding | deleterious(0.01) | possibly_damaging(0.784) | TCGA-46-3768-01 | Lung | lung squamous cell carcinoma | Male | <65 | III/IV | Chemotherapy | carboplatin | SD | |
COG3 | SNV | Missense_Mutation | novel | c.1235N>T | p.Pro412Leu | p.P412L | Q96JB2 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-85-7698-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | etoposide | CR |
COG3 | SNV | Missense_Mutation | novel | c.393G>C | p.Arg131Ser | p.R131S | Q96JB2 | protein_coding | tolerated(0.4) | benign(0.136) | TCGA-O2-A52N-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
COG3 | SNV | Missense_Mutation | novel | c.1397N>T | p.Tyr466Phe | p.Y466F | Q96JB2 | protein_coding | tolerated(0.58) | benign(0.092) | TCGA-CQ-6219-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
COG3 | SNV | Missense_Mutation | novel | c.1320N>C | p.Gln440His | p.Q440H | Q96JB2 | protein_coding | tolerated(0.09) | benign(0.015) | TCGA-CV-7433-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
COG3 | SNV | Missense_Mutation | c.1103N>T | p.Ser368Ile | p.S368I | Q96JB2 | protein_coding | deleterious(0) | probably_damaging(0.916) | TCGA-G9-6356-01 | Prostate | prostate adenocarcinoma | Male | <65 | 9 | Unknown | Unknown | SD | |
COG3 | SNV | Missense_Mutation | c.655A>G | p.Ser219Gly | p.S219G | Q96JB2 | protein_coding | tolerated(0.13) | benign(0.04) | TCGA-B7-5818-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
COG3 | SNV | Missense_Mutation | c.2029N>A | p.Glu677Lys | p.E677K | Q96JB2 | protein_coding | deleterious(0.04) | possibly_damaging(0.541) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
COG3 | SNV | Missense_Mutation | c.1616N>A | p.Pro539His | p.P539H | Q96JB2 | protein_coding | deleterious(0.02) | benign(0.094) | TCGA-BR-7707-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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