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Gene: CNOT10 |
Gene summary for CNOT10 |
Gene summary. |
Gene information | Species | Human | Gene symbol | CNOT10 | Gene ID | 25904 |
Gene name | CCR4-NOT transcription complex subunit 10 | |
Gene Alias | CNOT10 | |
Cytomap | 3p22.3 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q9H9A5 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
25904 | CNOT10 | LZE4T | Human | Esophagus | ESCC | 1.56e-08 | 2.85e-01 | 0.0811 |
25904 | CNOT10 | LZE7T | Human | Esophagus | ESCC | 1.37e-02 | 1.81e-01 | 0.0667 |
25904 | CNOT10 | LZE24T | Human | Esophagus | ESCC | 1.09e-04 | 1.80e-01 | 0.0596 |
25904 | CNOT10 | P1T-E | Human | Esophagus | ESCC | 1.70e-05 | 2.45e-01 | 0.0875 |
25904 | CNOT10 | P2T-E | Human | Esophagus | ESCC | 5.70e-16 | 1.83e-01 | 0.1177 |
25904 | CNOT10 | P4T-E | Human | Esophagus | ESCC | 6.67e-10 | 2.53e-01 | 0.1323 |
25904 | CNOT10 | P5T-E | Human | Esophagus | ESCC | 2.60e-04 | 8.74e-02 | 0.1327 |
25904 | CNOT10 | P8T-E | Human | Esophagus | ESCC | 1.03e-06 | 1.36e-01 | 0.0889 |
25904 | CNOT10 | P9T-E | Human | Esophagus | ESCC | 2.31e-04 | 1.76e-01 | 0.1131 |
25904 | CNOT10 | P10T-E | Human | Esophagus | ESCC | 2.61e-14 | 1.87e-01 | 0.116 |
25904 | CNOT10 | P11T-E | Human | Esophagus | ESCC | 1.11e-03 | 1.75e-01 | 0.1426 |
25904 | CNOT10 | P15T-E | Human | Esophagus | ESCC | 3.58e-11 | 2.41e-01 | 0.1149 |
25904 | CNOT10 | P16T-E | Human | Esophagus | ESCC | 2.86e-09 | 1.88e-01 | 0.1153 |
25904 | CNOT10 | P17T-E | Human | Esophagus | ESCC | 4.43e-04 | 1.58e-01 | 0.1278 |
25904 | CNOT10 | P19T-E | Human | Esophagus | ESCC | 1.60e-07 | 4.02e-01 | 0.1662 |
25904 | CNOT10 | P20T-E | Human | Esophagus | ESCC | 4.00e-08 | 1.39e-01 | 0.1124 |
25904 | CNOT10 | P21T-E | Human | Esophagus | ESCC | 2.61e-16 | 2.21e-01 | 0.1617 |
25904 | CNOT10 | P22T-E | Human | Esophagus | ESCC | 1.90e-11 | 1.24e-01 | 0.1236 |
25904 | CNOT10 | P23T-E | Human | Esophagus | ESCC | 1.62e-09 | 2.64e-01 | 0.108 |
25904 | CNOT10 | P24T-E | Human | Esophagus | ESCC | 6.21e-13 | 3.28e-01 | 0.1287 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006401110 | Esophagus | ESCC | RNA catabolic process | 204/8552 | 278/18723 | 3.39e-21 | 5.66e-19 | 204 |
GO:0034655110 | Esophagus | ESCC | nucleobase-containing compound catabolic process | 272/8552 | 407/18723 | 2.92e-18 | 2.90e-16 | 272 |
GO:0006402110 | Esophagus | ESCC | mRNA catabolic process | 170/8552 | 232/18723 | 8.70e-18 | 8.00e-16 | 170 |
GO:0006417111 | Esophagus | ESCC | regulation of translation | 304/8552 | 468/18723 | 1.53e-17 | 1.33e-15 | 304 |
GO:004670018 | Esophagus | ESCC | heterocycle catabolic process | 286/8552 | 445/18723 | 1.12e-15 | 7.47e-14 | 286 |
GO:004427019 | Esophagus | ESCC | cellular nitrogen compound catabolic process | 288/8552 | 451/18723 | 3.03e-15 | 1.79e-13 | 288 |
GO:001943918 | Esophagus | ESCC | aromatic compound catabolic process | 295/8552 | 467/18723 | 1.09e-14 | 5.98e-13 | 295 |
GO:190136118 | Esophagus | ESCC | organic cyclic compound catabolic process | 307/8552 | 495/18723 | 9.99e-14 | 4.80e-12 | 307 |
GO:003424914 | Esophagus | ESCC | negative regulation of cellular amide metabolic process | 144/8552 | 273/18723 | 1.08e-02 | 3.67e-02 | 144 |
GO:00194396 | Liver | NAFLD | aromatic compound catabolic process | 102/1882 | 467/18723 | 2.29e-14 | 1.91e-11 | 102 |
GO:19013616 | Liver | NAFLD | organic cyclic compound catabolic process | 105/1882 | 495/18723 | 7.04e-14 | 5.15e-11 | 105 |
GO:00442707 | Liver | NAFLD | cellular nitrogen compound catabolic process | 93/1882 | 451/18723 | 1.04e-11 | 4.34e-09 | 93 |
GO:00467006 | Liver | NAFLD | heterocycle catabolic process | 92/1882 | 445/18723 | 1.16e-11 | 4.52e-09 | 92 |
GO:00064026 | Liver | NAFLD | mRNA catabolic process | 56/1882 | 232/18723 | 3.49e-10 | 9.27e-08 | 56 |
GO:00346556 | Liver | NAFLD | nucleobase-containing compound catabolic process | 80/1882 | 407/18723 | 3.07e-09 | 4.61e-07 | 80 |
GO:00064016 | Liver | NAFLD | RNA catabolic process | 61/1882 | 278/18723 | 3.26e-09 | 4.76e-07 | 61 |
GO:00064177 | Liver | NAFLD | regulation of translation | 85/1882 | 468/18723 | 4.58e-08 | 4.54e-06 | 85 |
GO:00171483 | Liver | NAFLD | negative regulation of translation | 43/1882 | 245/18723 | 2.05e-04 | 3.56e-03 | 43 |
GO:00342493 | Liver | NAFLD | negative regulation of cellular amide metabolic process | 46/1882 | 273/18723 | 3.27e-04 | 5.04e-03 | 46 |
GO:004427021 | Liver | HCC | cellular nitrogen compound catabolic process | 303/7958 | 451/18723 | 9.76e-27 | 3.64e-24 | 303 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0301824 | Esophagus | ESCC | RNA degradation | 62/4205 | 79/8465 | 1.18e-07 | 9.39e-07 | 4.81e-07 | 62 |
hsa0301834 | Esophagus | ESCC | RNA degradation | 62/4205 | 79/8465 | 1.18e-07 | 9.39e-07 | 4.81e-07 | 62 |
hsa030182 | Liver | HCC | RNA degradation | 58/4020 | 79/8465 | 2.29e-06 | 2.19e-05 | 1.22e-05 | 58 |
hsa030183 | Liver | HCC | RNA degradation | 58/4020 | 79/8465 | 2.29e-06 | 2.19e-05 | 1.22e-05 | 58 |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CNOT10 | insertion | Frame_Shift_Ins | novel | c.712dupA | p.Met238AsnfsTer6 | p.M238Nfs*6 | Q9H9A5 | protein_coding | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
CNOT10 | SNV | Missense_Mutation | c.1854N>C | p.Lys618Asn | p.K618N | Q9H9A5 | protein_coding | tolerated(0.44) | benign(0.003) | TCGA-DD-A73C-01 | Liver | liver hepatocellular carcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
CNOT10 | SNV | Missense_Mutation | c.1414A>G | p.Lys472Glu | p.K472E | Q9H9A5 | protein_coding | tolerated(0.12) | benign(0.296) | TCGA-KR-A7K0-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
CNOT10 | SNV | Missense_Mutation | c.2039A>G | p.Asn680Ser | p.N680S | Q9H9A5 | protein_coding | tolerated(0.64) | benign(0.15) | TCGA-50-6592-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
CNOT10 | SNV | Missense_Mutation | c.656N>G | p.Tyr219Cys | p.Y219C | Q9H9A5 | protein_coding | tolerated(0.11) | probably_damaging(0.996) | TCGA-55-6979-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | PD | |
CNOT10 | SNV | Missense_Mutation | c.1053G>C | p.Leu351Phe | p.L351F | Q9H9A5 | protein_coding | tolerated(0.08) | possibly_damaging(0.483) | TCGA-55-A48Y-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | CR | |
CNOT10 | SNV | Missense_Mutation | c.355N>A | p.Asp119Asn | p.D119N | Q9H9A5 | protein_coding | tolerated(0.44) | benign(0.005) | TCGA-78-7542-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
CNOT10 | insertion | In_Frame_Ins | novel | c.382_383insTATATCATTCCAAATATATTT | p.Ala128delinsValTyrHisSerLysTyrIleSer | p.A128delinsVYHSKYIS | Q9H9A5 | protein_coding | TCGA-86-8669-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | CR | ||
CNOT10 | SNV | Missense_Mutation | c.517N>A | p.Tyr173Asn | p.Y173N | Q9H9A5 | protein_coding | tolerated(0.14) | possibly_damaging(0.656) | TCGA-CN-4731-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Chemotherapy | erbitux | PD | |
CNOT10 | SNV | Missense_Mutation | novel | c.1573N>A | p.Leu525Ile | p.L525I | Q9H9A5 | protein_coding | tolerated(0.05) | probably_damaging(0.998) | TCGA-CR-6472-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | paclitaxel | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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