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Gene: CMTR2 |
Gene summary for CMTR2 |
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Gene information | Species | Human | Gene symbol | CMTR2 | Gene ID | 55783 |
Gene name | cap methyltransferase 2 | |
Gene Alias | AFT | |
Cytomap | 16q22.2 | |
Gene Type | protein-coding | GO ID | GO:0001510 | UniProtAcc | Q8IYT2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55783 | CMTR2 | C04 | Human | Oral cavity | OSCC | 6.53e-10 | 4.25e-01 | 0.2633 |
55783 | CMTR2 | C21 | Human | Oral cavity | OSCC | 1.96e-26 | 7.23e-01 | 0.2678 |
55783 | CMTR2 | C30 | Human | Oral cavity | OSCC | 1.23e-17 | 6.60e-01 | 0.3055 |
55783 | CMTR2 | C43 | Human | Oral cavity | OSCC | 1.39e-06 | 1.51e-01 | 0.1704 |
55783 | CMTR2 | C46 | Human | Oral cavity | OSCC | 2.63e-13 | 3.27e-01 | 0.1673 |
55783 | CMTR2 | C57 | Human | Oral cavity | OSCC | 2.24e-04 | 2.09e-01 | 0.1679 |
55783 | CMTR2 | C07 | Human | Oral cavity | OSCC | 1.36e-02 | 5.09e-01 | 0.2491 |
55783 | CMTR2 | C08 | Human | Oral cavity | OSCC | 4.11e-09 | 1.73e-01 | 0.1919 |
55783 | CMTR2 | LP15 | Human | Oral cavity | LP | 1.36e-02 | 5.09e-01 | 0.2174 |
55783 | CMTR2 | SYSMH1 | Human | Oral cavity | OSCC | 1.90e-02 | 1.33e-01 | 0.1127 |
55783 | CMTR2 | SYSMH2 | Human | Oral cavity | OSCC | 7.04e-06 | 2.31e-01 | 0.2326 |
55783 | CMTR2 | SYSMH3 | Human | Oral cavity | OSCC | 2.28e-11 | 3.15e-01 | 0.2442 |
55783 | CMTR2 | SYSMH5 | Human | Oral cavity | OSCC | 5.72e-10 | 2.79e-01 | 0.0647 |
55783 | CMTR2 | male-WTA | Human | Thyroid | PTC | 2.88e-04 | 3.38e-02 | 0.1037 |
55783 | CMTR2 | PTC01 | Human | Thyroid | PTC | 2.24e-15 | 1.84e-01 | 0.1899 |
55783 | CMTR2 | PTC04 | Human | Thyroid | PTC | 1.12e-14 | 2.79e-01 | 0.1927 |
55783 | CMTR2 | PTC05 | Human | Thyroid | PTC | 1.47e-13 | 5.23e-01 | 0.2065 |
55783 | CMTR2 | PTC06 | Human | Thyroid | PTC | 5.15e-23 | 5.46e-01 | 0.2057 |
55783 | CMTR2 | PTC07 | Human | Thyroid | PTC | 2.99e-23 | 3.44e-01 | 0.2044 |
55783 | CMTR2 | ATC09 | Human | Thyroid | ATC | 5.58e-08 | 2.10e-01 | 0.2871 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00094511 | Oral cavity | OSCC | RNA modification | 95/7305 | 167/18723 | 2.05e-06 | 2.62e-05 | 95 |
GO:00434142 | Oral cavity | OSCC | macromolecule methylation | 149/7305 | 316/18723 | 1.82e-03 | 8.60e-03 | 149 |
GO:00322591 | Oral cavity | OSCC | methylation | 168/7305 | 364/18723 | 3.03e-03 | 1.31e-02 | 168 |
GO:00800091 | Oral cavity | OSCC | mRNA methylation | 11/7305 | 16/18723 | 1.56e-02 | 4.99e-02 | 11 |
GO:00322594 | Thyroid | PTC | methylation | 146/5968 | 364/18723 | 4.99e-04 | 3.26e-03 | 146 |
GO:00434145 | Thyroid | PTC | macromolecule methylation | 127/5968 | 316/18723 | 1.02e-03 | 6.07e-03 | 127 |
GO:004341412 | Thyroid | ATC | macromolecule methylation | 131/6293 | 316/18723 | 2.01e-03 | 9.60e-03 | 131 |
GO:003225911 | Thyroid | ATC | methylation | 148/6293 | 364/18723 | 2.69e-03 | 1.23e-02 | 148 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CMTR2 | SNV | Missense_Mutation | rs200731984 | c.1672G>A | p.Glu558Lys | p.E558K | Q8IYT2 | protein_coding | tolerated(0.06) | benign(0.017) | TCGA-D1-A17Q-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CMTR2 | SNV | Missense_Mutation | rs760052126 | c.1775N>G | p.Lys592Arg | p.K592R | Q8IYT2 | protein_coding | tolerated(0.38) | benign(0.036) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
CMTR2 | SNV | Missense_Mutation | novel | c.755N>A | p.Ser252Tyr | p.S252Y | Q8IYT2 | protein_coding | tolerated(0.07) | probably_damaging(0.989) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
CMTR2 | SNV | Missense_Mutation | novel | c.710N>A | p.Ser237Asn | p.S237N | Q8IYT2 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CMTR2 | SNV | Missense_Mutation | rs770519394 | c.547G>A | p.Asp183Asn | p.D183N | Q8IYT2 | protein_coding | tolerated(0.65) | benign(0) | TCGA-EO-A22X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response |
CMTR2 | SNV | Missense_Mutation | novel | c.899N>C | p.Val300Ala | p.V300A | Q8IYT2 | protein_coding | deleterious(0) | possibly_damaging(0.565) | TCGA-EY-A1GI-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CMTR2 | insertion | Nonsense_Mutation | novel | c.1174_1175insTATTAATCTGAACATTTTCATGTTC | p.Lys392IlefsTer4 | p.K392Ifs*4 | Q8IYT2 | protein_coding | TCGA-A5-A0G3-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | PD | ||
CMTR2 | SNV | Missense_Mutation | novel | c.1103N>G | p.His368Arg | p.H368R | Q8IYT2 | protein_coding | deleterious(0.04) | possibly_damaging(0.84) | TCGA-G3-AAV3-01 | Liver | liver hepatocellular carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CMTR2 | SNV | Missense_Mutation | novel | c.2184G>T | p.Glu728Asp | p.E728D | Q8IYT2 | protein_coding | deleterious(0.01) | probably_damaging(0.991) | TCGA-05-4396-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
CMTR2 | SNV | Missense_Mutation | c.1451G>C | p.Gly484Ala | p.G484A | Q8IYT2 | protein_coding | tolerated(0.06) | benign(0.444) | TCGA-44-3398-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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