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Gene: CLCA2 |
Gene summary for CLCA2 |
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Gene information | Species | Human | Gene symbol | CLCA2 | Gene ID | 9635 |
Gene name | chloride channel accessory 2 | |
Gene Alias | CACC | |
Cytomap | 1p22.3 | |
Gene Type | protein-coding | GO ID | GO:0006508 | UniProtAcc | Q9UQC9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9635 | CLCA2 | CA_HPV_1 | Human | Cervix | CC | 4.77e-06 | -2.41e-01 | 0.0264 |
9635 | CLCA2 | HSIL_HPV_1 | Human | Cervix | HSIL_HPV | 1.84e-04 | -2.59e-01 | 0.0116 |
9635 | CLCA2 | HSIL_HPV_2 | Human | Cervix | HSIL_HPV | 2.84e-03 | -2.30e-01 | 0.0208 |
9635 | CLCA2 | Tumor | Human | Cervix | CC | 1.38e-43 | 8.95e-01 | 0.1241 |
9635 | CLCA2 | sample3 | Human | Cervix | CC | 1.61e-45 | 8.28e-01 | 0.1387 |
9635 | CLCA2 | H2 | Human | Cervix | HSIL_HPV | 2.46e-04 | -2.41e-01 | 0.0632 |
9635 | CLCA2 | T1 | Human | Cervix | CC | 3.99e-08 | -2.68e-01 | 0.0918 |
9635 | CLCA2 | T3 | Human | Cervix | CC | 2.79e-44 | 8.11e-01 | 0.1389 |
9635 | CLCA2 | LZE4T | Human | Esophagus | ESCC | 2.36e-08 | 5.50e-01 | 0.0811 |
9635 | CLCA2 | LZE7T | Human | Esophagus | ESCC | 7.18e-05 | 1.53e+00 | 0.0667 |
9635 | CLCA2 | P1T-E | Human | Esophagus | ESCC | 1.87e-02 | 7.90e-01 | 0.0875 |
9635 | CLCA2 | P4T-E | Human | Esophagus | ESCC | 1.26e-04 | 2.69e-01 | 0.1323 |
9635 | CLCA2 | P5T-E | Human | Esophagus | ESCC | 3.67e-10 | 4.04e-01 | 0.1327 |
9635 | CLCA2 | P8T-E | Human | Esophagus | ESCC | 1.60e-03 | -2.84e-01 | 0.0889 |
9635 | CLCA2 | P9T-E | Human | Esophagus | ESCC | 4.27e-15 | 5.76e-01 | 0.1131 |
9635 | CLCA2 | P10T-E | Human | Esophagus | ESCC | 9.32e-17 | 5.77e-01 | 0.116 |
9635 | CLCA2 | P11T-E | Human | Esophagus | ESCC | 4.64e-10 | 1.54e+00 | 0.1426 |
9635 | CLCA2 | P12T-E | Human | Esophagus | ESCC | 4.30e-37 | 1.82e+00 | 0.1122 |
9635 | CLCA2 | P15T-E | Human | Esophagus | ESCC | 1.51e-14 | 7.79e-01 | 0.1149 |
9635 | CLCA2 | P16T-E | Human | Esophagus | ESCC | 6.61e-09 | -4.83e-02 | 0.1153 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CLCA2 | SNV | Missense_Mutation | novel | c.1730N>G | p.Tyr577Cys | p.Y577C | Q9UQC9 | protein_coding | deleterious(0.03) | benign(0.329) | TCGA-DI-A1BU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
CLCA2 | SNV | Missense_Mutation | rs763764816 | c.1586N>T | p.Thr529Met | p.T529M | Q9UQC9 | protein_coding | tolerated(0.07) | benign(0.073) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CLCA2 | SNV | Missense_Mutation | novel | c.2639N>G | p.Asn880Ser | p.N880S | Q9UQC9 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CLCA2 | SNV | Missense_Mutation | novel | c.2729N>G | p.Met910Arg | p.M910R | Q9UQC9 | protein_coding | tolerated(0.13) | benign(0.015) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CLCA2 | SNV | Missense_Mutation | novel | c.549C>A | p.Phe183Leu | p.F183L | Q9UQC9 | protein_coding | deleterious(0.03) | benign(0.066) | TCGA-EO-A22X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response |
CLCA2 | SNV | Missense_Mutation | novel | c.1006G>A | p.Glu336Lys | p.E336K | Q9UQC9 | protein_coding | tolerated(0.33) | benign(0.396) | TCGA-EO-A22X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response |
CLCA2 | SNV | Missense_Mutation | rs750282125 | c.1118G>A | p.Arg373Gln | p.R373Q | Q9UQC9 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-EO-A22X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response |
CLCA2 | SNV | Missense_Mutation | rs375894557 | c.1678N>T | p.Arg560Trp | p.R560W | Q9UQC9 | protein_coding | deleterious(0.01) | possibly_damaging(0.817) | TCGA-EO-A3AV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | CR |
CLCA2 | SNV | Missense_Mutation | novel | c.2375N>G | p.Phe792Cys | p.F792C | Q9UQC9 | protein_coding | deleterious(0.01) | possibly_damaging(0.751) | TCGA-EO-A3AY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
CLCA2 | SNV | Missense_Mutation | novel | c.2777N>A | p.Thr926Asn | p.T926N | Q9UQC9 | protein_coding | deleterious(0.03) | benign(0.143) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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