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Gene: CHN1 |
Gene summary for CHN1 |
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Gene information | Species | Human | Gene symbol | CHN1 | Gene ID | 1123 |
Gene name | chimerin 1 | |
Gene Alias | ARHGAP2 | |
Cytomap | 2q31.1 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | P15882 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1123 | CHN1 | HTA12-15-2 | Human | Pancreas | PDAC | 4.06e-02 | 2.64e-01 | 0.2315 |
1123 | CHN1 | HTA12-23-1 | Human | Pancreas | PDAC | 5.20e-08 | 7.01e-01 | 0.3405 |
1123 | CHN1 | HTA12-25-1 | Human | Pancreas | PDAC | 3.64e-05 | 4.50e-01 | 0.313 |
1123 | CHN1 | HTA12-26-1 | Human | Pancreas | PDAC | 5.25e-22 | 8.69e-01 | 0.3728 |
1123 | CHN1 | HTA12-29-1 | Human | Pancreas | PDAC | 2.01e-48 | 9.40e-01 | 0.3722 |
1123 | CHN1 | HTA12-32-1 | Human | Pancreas | PDAC | 4.65e-02 | 6.19e-01 | 0.3624 |
1123 | CHN1 | ATC09 | Human | Thyroid | ATC | 2.26e-06 | 2.46e-01 | 0.2871 |
1123 | CHN1 | ATC11 | Human | Thyroid | ATC | 7.49e-03 | 2.46e-01 | 0.3386 |
1123 | CHN1 | ATC12 | Human | Thyroid | ATC | 4.51e-33 | 7.77e-01 | 0.34 |
1123 | CHN1 | ATC13 | Human | Thyroid | ATC | 2.37e-16 | 3.00e-01 | 0.34 |
1123 | CHN1 | ATC1 | Human | Thyroid | ATC | 1.52e-06 | 2.72e-01 | 0.2878 |
1123 | CHN1 | ATC2 | Human | Thyroid | ATC | 4.44e-15 | 1.19e+00 | 0.34 |
1123 | CHN1 | ATC3 | Human | Thyroid | ATC | 6.22e-03 | 2.04e-01 | 0.338 |
1123 | CHN1 | ATC4 | Human | Thyroid | ATC | 1.79e-43 | 1.01e+00 | 0.34 |
1123 | CHN1 | ATC5 | Human | Thyroid | ATC | 5.92e-17 | 3.25e-01 | 0.34 |
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Tissue | Expression Dynamics | Abbreviation |
Thyroid | ![]() | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001097523 | Thyroid | ATC | regulation of neuron projection development | 212/6293 | 445/18723 | 4.16e-10 | 1.14e-08 | 212 |
GO:006156423 | Thyroid | ATC | axon development | 220/6293 | 467/18723 | 6.85e-10 | 1.80e-08 | 220 |
GO:000740919 | Thyroid | ATC | axonogenesis | 197/6293 | 418/18723 | 5.09e-09 | 1.13e-07 | 197 |
GO:005105618 | Thyroid | ATC | regulation of small GTPase mediated signal transduction | 141/6293 | 302/18723 | 1.43e-06 | 1.77e-05 | 141 |
GO:005077011 | Thyroid | ATC | regulation of axonogenesis | 80/6293 | 154/18723 | 1.95e-06 | 2.34e-05 | 80 |
GO:004308719 | Thyroid | ATC | regulation of GTPase activity | 153/6293 | 348/18723 | 3.24e-05 | 2.68e-04 | 153 |
GO:00074113 | Thyroid | ATC | axon guidance | 96/6293 | 227/18723 | 3.74e-03 | 1.63e-02 | 96 |
GO:00974853 | Thyroid | ATC | neuron projection guidance | 96/6293 | 228/18723 | 4.36e-03 | 1.81e-02 | 96 |
GO:004354715 | Thyroid | ATC | positive regulation of GTPase activity | 106/6293 | 255/18723 | 4.58e-03 | 1.89e-02 | 106 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CHN1 | SNV | Missense_Mutation | novel | c.361N>G | p.Leu121Val | p.L121V | P15882 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-CG-4460-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | capecitabine | PD |
CHN1 | SNV | Missense_Mutation | c.230G>A | p.Arg77Gln | p.R77Q | P15882 | protein_coding | tolerated(0.07) | benign(0.377) | TCGA-CG-4466-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CHN1 | SNV | Missense_Mutation | rs373546784 | c.820G>A | p.Val274Met | p.V274M | P15882 | protein_coding | deleterious(0) | probably_damaging(0.986) | TCGA-VQ-A94R-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | fluorouracil | PD |
CHN1 | SNV | Missense_Mutation | rs371299944 | c.1007T>C | p.Ile336Thr | p.I336T | P15882 | protein_coding | tolerated(0.06) | possibly_damaging(0.696) | TCGA-FE-A236-01 | Thyroid | thyroid carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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