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Gene: CFAP221 |
Gene summary for CFAP221 |
Gene summary. |
Gene information | Species | Human | Gene symbol | CFAP221 | Gene ID | 200373 |
Gene name | cilia and flagella associated protein 221 | |
Gene Alias | FAP221 | |
Cytomap | 2q14.2 | |
Gene Type | protein-coding | GO ID | GO:0003341 | UniProtAcc | Q4G0U5 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
200373 | CFAP221 | RNA-P10T2-P10T2-1 | Human | Lung | AAH | 2.32e-02 | 8.56e-01 | -0.1271 |
200373 | CFAP221 | RNA-P10T2-P10T2-2 | Human | Lung | AAH | 1.56e-04 | 8.42e-01 | -0.1406 |
200373 | CFAP221 | RNA-P10T2-P10T2-3 | Human | Lung | AAH | 2.64e-02 | 7.39e-01 | -0.1408 |
200373 | CFAP221 | RNA-P10T2-P10T2-4 | Human | Lung | AAH | 1.41e-02 | 6.75e-01 | -0.138 |
200373 | CFAP221 | RNA-P25T1-P25T1-1 | Human | Lung | AIS | 1.53e-18 | 8.74e-01 | -0.2116 |
200373 | CFAP221 | RNA-P25T1-P25T1-2 | Human | Lung | AIS | 4.12e-05 | 7.65e-01 | -0.1941 |
200373 | CFAP221 | RNA-P25T1-P25T1-3 | Human | Lung | AIS | 2.52e-07 | 7.76e-01 | -0.2107 |
200373 | CFAP221 | RNA-P25T1-P25T1-4 | Human | Lung | AIS | 1.45e-10 | 7.57e-01 | -0.2119 |
200373 | CFAP221 | RNA-P6T2-P6T2-1 | Human | Lung | IAC | 1.19e-30 | 9.14e-01 | -0.0166 |
200373 | CFAP221 | RNA-P6T2-P6T2-2 | Human | Lung | IAC | 5.11e-38 | 1.02e+00 | -0.0132 |
200373 | CFAP221 | RNA-P6T2-P6T2-3 | Human | Lung | IAC | 1.66e-37 | 9.49e-01 | -0.013 |
200373 | CFAP221 | RNA-P6T2-P6T2-4 | Human | Lung | IAC | 3.74e-26 | 8.55e-01 | -0.0121 |
200373 | CFAP221 | RNA-P7T1-P7T1-1 | Human | Lung | AIS | 3.98e-12 | 9.68e-01 | -0.0961 |
200373 | CFAP221 | RNA-P7T1-P7T1-2 | Human | Lung | AIS | 7.88e-12 | 8.56e-01 | -0.0876 |
200373 | CFAP221 | RNA-P7T1-P7T1-3 | Human | Lung | AIS | 5.56e-09 | 8.56e-01 | -0.0822 |
200373 | CFAP221 | RNA-P7T1-P7T1-4 | Human | Lung | AIS | 3.11e-10 | 8.87e-01 | -0.0809 |
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Transcriptomic changes along malignancy continuum. |
Tissue | Expression Dynamics | Abbreviation |
Lung | AAH: Atypical adenomatous hyperplasia | |
AIS: Adenocarcinoma in situ | ||
IAC: Invasive lung adenocarcinoma | ||
MIA: Minimally invasive adenocarcinoma |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0060271 | Lung | IAC | cilium assembly | 55/2061 | 337/18723 | 1.84e-03 | 1.88e-02 | 55 |
GO:0044782 | Lung | IAC | cilium organization | 58/2061 | 368/18723 | 3.15e-03 | 2.75e-02 | 58 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CFAP221 | SNV | Missense_Mutation | novel | c.153A>C | p.Lys51Asn | p.K51N | Q4G0U5 | protein_coding | tolerated(0.12) | benign(0.304) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
CFAP221 | SNV | Missense_Mutation | rs753705841 | c.2132C>T | p.Thr711Met | p.T711M | Q4G0U5 | protein_coding | tolerated(0.07) | benign(0.046) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
CFAP221 | SNV | Missense_Mutation | novel | c.1490G>A | p.Gly497Asp | p.G497D | Q4G0U5 | protein_coding | tolerated(0.61) | benign(0.055) | TCGA-05-4244-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
CFAP221 | SNV | Missense_Mutation | novel | c.1780A>C | p.Lys594Gln | p.K594Q | Q4G0U5 | protein_coding | tolerated(0.54) | benign(0.013) | TCGA-55-A4DG-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
CFAP221 | SNV | Missense_Mutation | novel | c.2077N>C | p.Glu693Gln | p.E693Q | Q4G0U5 | protein_coding | deleterious(0.03) | possibly_damaging(0.656) | TCGA-78-7162-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
CFAP221 | SNV | Missense_Mutation | novel | c.1484N>C | p.Lys495Thr | p.K495T | Q4G0U5 | protein_coding | tolerated(0.08) | benign(0.219) | TCGA-78-8640-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CFAP221 | SNV | Missense_Mutation | c.1957N>A | p.Asp653Asn | p.D653N | Q4G0U5 | protein_coding | tolerated(0.7) | benign(0.01) | TCGA-18-3419-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
CFAP221 | SNV | Missense_Mutation | novel | c.1216T>C | p.Tyr406His | p.Y406H | Q4G0U5 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-34-5241-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
CFAP221 | SNV | Missense_Mutation | c.1101N>G | p.Asp367Glu | p.D367E | Q4G0U5 | protein_coding | deleterious(0.02) | possibly_damaging(0.521) | TCGA-39-5031-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CFAP221 | SNV | Missense_Mutation | c.1462N>T | p.Asp488Tyr | p.D488Y | Q4G0U5 | protein_coding | deleterious(0.03) | possibly_damaging(0.742) | TCGA-66-2771-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | carboplatin | CR |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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