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Gene: CDHR1 |
Gene summary for CDHR1 |
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Gene information | Species | Human | Gene symbol | CDHR1 | Gene ID | 92211 |
Gene name | cadherin related family member 1 | |
Gene Alias | CORD15 | |
Cytomap | 10q23.1 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | F1T0L2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
92211 | CDHR1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.72e-07 | -3.89e-01 | 0.0155 |
92211 | CDHR1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.24e-08 | -5.76e-01 | -0.1808 |
92211 | CDHR1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 3.80e-02 | -4.78e-01 | -0.0811 |
92211 | CDHR1 | HTA11_78_2000001011 | Human | Colorectum | AD | 8.71e-09 | -5.58e-01 | -0.1088 |
92211 | CDHR1 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.16e-03 | -3.88e-01 | -0.1001 |
92211 | CDHR1 | HTA11_6818_2000001021 | Human | Colorectum | AD | 1.53e-03 | -5.22e-01 | 0.0588 |
92211 | CDHR1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 7.50e-03 | -1.74e-01 | 0.294 |
92211 | CDHR1 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 1.32e-02 | -4.41e-02 | 0.281 |
92211 | CDHR1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 9.41e-06 | -3.85e-01 | 0.3859 |
92211 | CDHR1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 2.31e-13 | -5.33e-01 | 0.3005 |
92211 | CDHR1 | A001-C-207 | Human | Colorectum | FAP | 3.61e-02 | 4.08e-01 | 0.1278 |
92211 | CDHR1 | A015-C-203 | Human | Colorectum | FAP | 1.34e-50 | 9.92e-01 | -0.1294 |
92211 | CDHR1 | A015-C-204 | Human | Colorectum | FAP | 5.87e-10 | 5.93e-01 | -0.0228 |
92211 | CDHR1 | A014-C-040 | Human | Colorectum | FAP | 1.83e-20 | 1.11e+00 | -0.1184 |
92211 | CDHR1 | A002-C-201 | Human | Colorectum | FAP | 1.24e-08 | 2.91e-01 | 0.0324 |
92211 | CDHR1 | A001-C-108 | Human | Colorectum | FAP | 2.72e-13 | 4.17e-01 | -0.0272 |
92211 | CDHR1 | A002-C-021 | Human | Colorectum | FAP | 1.75e-12 | 5.38e-01 | 0.1171 |
92211 | CDHR1 | A002-C-205 | Human | Colorectum | FAP | 5.86e-13 | 3.55e-01 | -0.1236 |
92211 | CDHR1 | A014-C-108 | Human | Colorectum | FAP | 1.25e-16 | 7.90e-01 | -0.124 |
92211 | CDHR1 | A001-C-104 | Human | Colorectum | FAP | 6.20e-09 | 5.10e-01 | 0.0184 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0060249 | Colorectum | AD | anatomical structure homeostasis | 94/3918 | 314/18723 | 9.37e-05 | 1.42e-03 | 94 |
GO:0001894 | Colorectum | AD | tissue homeostasis | 81/3918 | 268/18723 | 1.96e-04 | 2.62e-03 | 81 |
GO:00018941 | Colorectum | SER | tissue homeostasis | 66/2897 | 268/18723 | 5.87e-05 | 1.37e-03 | 66 |
GO:00602491 | Colorectum | SER | anatomical structure homeostasis | 74/2897 | 314/18723 | 1.01e-04 | 2.13e-03 | 74 |
GO:00602492 | Colorectum | MSS | anatomical structure homeostasis | 84/3467 | 314/18723 | 1.87e-04 | 2.64e-03 | 84 |
GO:00018942 | Colorectum | MSS | tissue homeostasis | 72/3467 | 268/18723 | 4.53e-04 | 5.40e-03 | 72 |
GO:00018944 | Colorectum | FAP | tissue homeostasis | 61/2622 | 268/18723 | 6.71e-05 | 1.28e-03 | 61 |
GO:00602494 | Colorectum | FAP | anatomical structure homeostasis | 69/2622 | 314/18723 | 7.51e-05 | 1.37e-03 | 69 |
GO:00602495 | Colorectum | CRC | anatomical structure homeostasis | 57/2078 | 314/18723 | 1.24e-04 | 2.41e-03 | 57 |
GO:00018945 | Colorectum | CRC | tissue homeostasis | 48/2078 | 268/18723 | 5.56e-04 | 7.70e-03 | 48 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CDHR1 | SNV | Missense_Mutation | rs201004571 | c.1220N>A | p.Arg407Gln | p.R407Q | Q96JP9 | protein_coding | deleterious(0.03) | probably_damaging(0.976) | TCGA-D1-A17Q-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CDHR1 | SNV | Missense_Mutation | novel | c.1642G>A | p.Val548Met | p.V548M | Q96JP9 | protein_coding | tolerated(0.1) | probably_damaging(0.985) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
CDHR1 | SNV | Missense_Mutation | rs531420059 | c.355G>A | p.Glu119Lys | p.E119K | Q96JP9 | protein_coding | tolerated(0.09) | probably_damaging(0.919) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CDHR1 | SNV | Missense_Mutation | novel | c.707N>C | p.Val236Ala | p.V236A | Q96JP9 | protein_coding | deleterious(0) | possibly_damaging(0.549) | TCGA-EC-A1NJ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CDHR1 | SNV | Missense_Mutation | novel | c.967A>G | p.Thr323Ala | p.T323A | Q96JP9 | protein_coding | deleterious(0.03) | benign(0.068) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CDHR1 | SNV | Missense_Mutation | rs146783539 | c.1132N>T | p.Arg378Trp | p.R378W | Q96JP9 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-EO-A22T-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CDHR1 | SNV | Missense_Mutation | rs547812313 | c.1516N>A | p.Glu506Lys | p.E506K | Q96JP9 | protein_coding | tolerated(0.21) | benign(0.056) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CDHR1 | SNV | Missense_Mutation | novel | c.2541N>T | p.Lys847Asn | p.K847N | Q96JP9 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.546) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CDHR1 | SNV | Missense_Mutation | novel | c.1628G>T | p.Arg543Met | p.R543M | Q96JP9 | protein_coding | deleterious(0.01) | possibly_damaging(0.827) | TCGA-EO-A3KX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CDHR1 | SNV | Missense_Mutation | novel | c.844C>A | p.Leu282Ile | p.L282I | Q96JP9 | protein_coding | tolerated(0.4) | benign(0.031) | TCGA-EY-A1G8-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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