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Gene: CDCA7L |
Gene summary for CDCA7L |
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Gene information | Species | Human | Gene symbol | CDCA7L | Gene ID | 55536 |
Gene name | cell division cycle associated 7 like | |
Gene Alias | JPO2 | |
Cytomap | 7p15.3 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q96GN5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55536 | CDCA7L | LZE2T | Human | Esophagus | ESCC | 3.88e-03 | 3.51e-01 | 0.082 |
55536 | CDCA7L | LZE4T | Human | Esophagus | ESCC | 5.79e-09 | 1.97e-01 | 0.0811 |
55536 | CDCA7L | LZE5T | Human | Esophagus | ESCC | 1.57e-02 | 1.87e-01 | 0.0514 |
55536 | CDCA7L | LZE7T | Human | Esophagus | ESCC | 6.70e-04 | 3.66e-01 | 0.0667 |
55536 | CDCA7L | LZE8T | Human | Esophagus | ESCC | 2.60e-05 | 1.47e-01 | 0.067 |
55536 | CDCA7L | LZE24T | Human | Esophagus | ESCC | 3.65e-12 | 3.45e-01 | 0.0596 |
55536 | CDCA7L | LZE21T | Human | Esophagus | ESCC | 4.63e-04 | 3.65e-01 | 0.0655 |
55536 | CDCA7L | LZE6T | Human | Esophagus | ESCC | 4.70e-07 | 3.04e-01 | 0.0845 |
55536 | CDCA7L | P1T-E | Human | Esophagus | ESCC | 4.64e-10 | 5.92e-01 | 0.0875 |
55536 | CDCA7L | P2T-E | Human | Esophagus | ESCC | 3.77e-37 | 7.50e-01 | 0.1177 |
55536 | CDCA7L | P4T-E | Human | Esophagus | ESCC | 1.64e-13 | 4.06e-01 | 0.1323 |
55536 | CDCA7L | P5T-E | Human | Esophagus | ESCC | 7.19e-18 | 4.18e-01 | 0.1327 |
55536 | CDCA7L | P8T-E | Human | Esophagus | ESCC | 4.66e-38 | 6.75e-01 | 0.0889 |
55536 | CDCA7L | P9T-E | Human | Esophagus | ESCC | 2.82e-12 | 3.77e-01 | 0.1131 |
55536 | CDCA7L | P10T-E | Human | Esophagus | ESCC | 3.76e-58 | 1.10e+00 | 0.116 |
55536 | CDCA7L | P11T-E | Human | Esophagus | ESCC | 8.22e-12 | 6.10e-01 | 0.1426 |
55536 | CDCA7L | P12T-E | Human | Esophagus | ESCC | 4.50e-29 | 5.68e-01 | 0.1122 |
55536 | CDCA7L | P15T-E | Human | Esophagus | ESCC | 6.53e-31 | 6.88e-01 | 0.1149 |
55536 | CDCA7L | P16T-E | Human | Esophagus | ESCC | 3.00e-42 | 5.72e-01 | 0.1153 |
55536 | CDCA7L | P17T-E | Human | Esophagus | ESCC | 2.68e-18 | 3.92e-01 | 0.1278 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CDCA7L | SNV | Missense_Mutation | rs201734057 | c.512N>A | p.Arg171His | p.R171H | Q96GN5 | protein_coding | tolerated(0.58) | benign(0) | TCGA-67-3771-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CDCA7L | SNV | Missense_Mutation | rs369952841 | c.698C>T | p.Ala233Val | p.A233V | Q96GN5 | protein_coding | deleterious(0) | probably_damaging(0.96) | TCGA-66-2763-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CDCA7L | SNV | Missense_Mutation | novel | c.1067G>A | p.Cys356Tyr | p.C356Y | Q96GN5 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-68-8251-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | SD |
CDCA7L | SNV | Missense_Mutation | novel | c.616N>A | p.Glu206Lys | p.E206K | Q96GN5 | protein_coding | tolerated(0.24) | possibly_damaging(0.476) | TCGA-CN-4723-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
CDCA7L | SNV | Missense_Mutation | rs139249411 | c.817N>T | p.Arg273Trp | p.R273W | Q96GN5 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-CN-5369-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CDCA7L | SNV | Missense_Mutation | novel | c.467N>C | p.Lys156Thr | p.K156T | Q96GN5 | protein_coding | tolerated(0.29) | benign(0.001) | TCGA-CV-7101-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
CDCA7L | SNV | Missense_Mutation | c.1253N>T | p.Arg418Leu | p.R418L | Q96GN5 | protein_coding | deleterious(0) | probably_damaging(0.946) | TCGA-CV-7248-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CDCA7L | SNV | Missense_Mutation | novel | c.922N>T | p.Gly308Trp | p.G308W | Q96GN5 | protein_coding | deleterious(0) | probably_damaging(0.956) | TCGA-CV-7263-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
CDCA7L | SNV | Missense_Mutation | novel | c.611N>A | p.Arg204Gln | p.R204Q | Q96GN5 | protein_coding | tolerated(0.09) | benign(0.089) | TCGA-F7-A624-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
CDCA7L | SNV | Missense_Mutation | rs750543368 | c.389N>T | p.Pro130Leu | p.P130L | Q96GN5 | protein_coding | tolerated(0.11) | benign(0.015) | TCGA-HD-A633-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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