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Gene: CDC45 |
Gene summary for CDC45 |
Gene summary. |
Gene information | Species | Human | Gene symbol | CDC45 | Gene ID | 8318 |
Gene name | cell division cycle 45 | |
Gene Alias | CDC45L | |
Cytomap | 22q11.21 | |
Gene Type | protein-coding | GO ID | GO:0000075 | UniProtAcc | O75419 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8318 | CDC45 | LZE7T | Human | Esophagus | ESCC | 1.02e-03 | 2.84e-01 | 0.0667 |
8318 | CDC45 | LZE21T | Human | Esophagus | ESCC | 8.02e-04 | 2.06e-01 | 0.0655 |
8318 | CDC45 | P1T-E | Human | Esophagus | ESCC | 2.97e-02 | 2.04e-01 | 0.0875 |
8318 | CDC45 | P2T-E | Human | Esophagus | ESCC | 7.98e-13 | 3.67e-01 | 0.1177 |
8318 | CDC45 | P4T-E | Human | Esophagus | ESCC | 2.81e-07 | 2.54e-01 | 0.1323 |
8318 | CDC45 | P5T-E | Human | Esophagus | ESCC | 4.24e-18 | 3.84e-01 | 0.1327 |
8318 | CDC45 | P10T-E | Human | Esophagus | ESCC | 2.05e-07 | 3.14e-01 | 0.116 |
8318 | CDC45 | P16T-E | Human | Esophagus | ESCC | 2.03e-09 | 2.56e-01 | 0.1153 |
8318 | CDC45 | P21T-E | Human | Esophagus | ESCC | 7.31e-14 | 4.72e-01 | 0.1617 |
8318 | CDC45 | P22T-E | Human | Esophagus | ESCC | 1.66e-02 | 1.24e-01 | 0.1236 |
8318 | CDC45 | P24T-E | Human | Esophagus | ESCC | 4.30e-10 | 2.85e-01 | 0.1287 |
8318 | CDC45 | P26T-E | Human | Esophagus | ESCC | 1.88e-04 | 2.16e-01 | 0.1276 |
8318 | CDC45 | P28T-E | Human | Esophagus | ESCC | 9.56e-08 | 1.79e-01 | 0.1149 |
8318 | CDC45 | P30T-E | Human | Esophagus | ESCC | 4.44e-04 | 4.38e-01 | 0.137 |
8318 | CDC45 | P31T-E | Human | Esophagus | ESCC | 3.89e-12 | 3.59e-01 | 0.1251 |
8318 | CDC45 | P32T-E | Human | Esophagus | ESCC | 1.30e-15 | 4.43e-01 | 0.1666 |
8318 | CDC45 | P37T-E | Human | Esophagus | ESCC | 3.40e-10 | 2.98e-01 | 0.1371 |
8318 | CDC45 | P48T-E | Human | Esophagus | ESCC | 3.75e-03 | 1.32e-01 | 0.0959 |
8318 | CDC45 | P52T-E | Human | Esophagus | ESCC | 1.13e-16 | 4.12e-01 | 0.1555 |
8318 | CDC45 | P65T-E | Human | Esophagus | ESCC | 3.99e-04 | 1.50e-01 | 0.0978 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00062604 | Esophagus | ESCC | DNA replication | 181/8552 | 260/18723 | 3.55e-15 | 2.05e-13 | 181 |
GO:190198713 | Esophagus | ESCC | regulation of cell cycle phase transition | 242/8552 | 390/18723 | 3.86e-11 | 1.26e-09 | 242 |
GO:00457865 | Esophagus | ESCC | negative regulation of cell cycle | 236/8552 | 385/18723 | 3.62e-10 | 9.93e-09 | 236 |
GO:00000754 | Esophagus | ESCC | cell cycle checkpoint | 117/8552 | 169/18723 | 4.47e-10 | 1.17e-08 | 117 |
GO:00062612 | Esophagus | ESCC | DNA-dependent DNA replication | 100/8552 | 151/18723 | 2.61e-07 | 3.94e-06 | 100 |
GO:00109484 | Esophagus | ESCC | negative regulation of cell cycle process | 177/8552 | 294/18723 | 3.26e-07 | 4.59e-06 | 177 |
GO:00315705 | Esophagus | ESCC | DNA integrity checkpoint | 83/8552 | 123/18723 | 8.17e-07 | 1.06e-05 | 83 |
GO:19019883 | Esophagus | ESCC | negative regulation of cell cycle phase transition | 151/8552 | 249/18723 | 1.28e-06 | 1.57e-05 | 151 |
GO:00063024 | Esophagus | ESCC | double-strand break repair | 152/8552 | 251/18723 | 1.33e-06 | 1.62e-05 | 152 |
GO:00062701 | Esophagus | ESCC | DNA replication initiation | 27/8552 | 34/18723 | 6.01e-05 | 4.62e-04 | 27 |
GO:00063101 | Esophagus | ESCC | DNA recombination | 168/8552 | 305/18723 | 5.58e-04 | 3.05e-03 | 168 |
GO:00007241 | Esophagus | ESCC | double-strand break repair via homologous recombination | 79/8552 | 138/18723 | 4.05e-03 | 1.62e-02 | 79 |
GO:00007251 | Esophagus | ESCC | recombinational repair | 80/8552 | 140/18723 | 4.10e-03 | 1.63e-02 | 80 |
GO:1902969 | Esophagus | ESCC | mitotic DNA replication | 11/8552 | 14/18723 | 1.30e-02 | 4.27e-02 | 11 |
GO:00062603 | Oral cavity | OSCC | DNA replication | 159/7305 | 260/18723 | 3.25e-13 | 1.59e-11 | 159 |
GO:19019875 | Oral cavity | OSCC | regulation of cell cycle phase transition | 209/7305 | 390/18723 | 2.79e-09 | 6.42e-08 | 209 |
GO:00457864 | Oral cavity | OSCC | negative regulation of cell cycle | 206/7305 | 385/18723 | 4.28e-09 | 9.55e-08 | 206 |
GO:00000753 | Oral cavity | OSCC | cell cycle checkpoint | 101/7305 | 169/18723 | 3.53e-08 | 6.68e-07 | 101 |
GO:19019882 | Oral cavity | OSCC | negative regulation of cell cycle phase transition | 136/7305 | 249/18723 | 3.81e-07 | 5.70e-06 | 136 |
GO:00109483 | Oral cavity | OSCC | negative regulation of cell cycle process | 155/7305 | 294/18723 | 1.11e-06 | 1.48e-05 | 155 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0411023 | Esophagus | ESCC | Cell cycle | 126/4205 | 157/8465 | 1.34e-15 | 5.60e-14 | 2.87e-14 | 126 |
hsa0411033 | Esophagus | ESCC | Cell cycle | 126/4205 | 157/8465 | 1.34e-15 | 5.60e-14 | 2.87e-14 | 126 |
hsa041108 | Oral cavity | OSCC | Cell cycle | 118/3704 | 157/8465 | 7.15e-16 | 2.66e-14 | 1.35e-14 | 118 |
hsa0411015 | Oral cavity | OSCC | Cell cycle | 118/3704 | 157/8465 | 7.15e-16 | 2.66e-14 | 1.35e-14 | 118 |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CDC45 | SNV | Missense_Mutation | novel | c.391N>A | p.Glu131Lys | p.E131K | O75419 | protein_coding | deleterious(0.01) | benign(0.287) | TCGA-34-2600-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CDC45 | SNV | Missense_Mutation | novel | c.779N>T | p.Trp260Leu | p.W260L | O75419 | protein_coding | tolerated(0.51) | benign(0.007) | TCGA-52-7812-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | paclitaxel | PD |
CDC45 | SNV | Missense_Mutation | novel | c.492N>G | p.Ile164Met | p.I164M | O75419 | protein_coding | tolerated(0.13) | benign(0.033) | TCGA-56-7222-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | PD |
CDC45 | SNV | Missense_Mutation | novel | c.958N>T | p.Asp320Tyr | p.D320Y | O75419 | protein_coding | deleterious(0) | possibly_damaging(0.87) | TCGA-O2-A52Q-01 | Lung | lung squamous cell carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
CDC45 | SNV | Missense_Mutation | rs61752240 | c.418N>A | p.Asp140Asn | p.D140N | O75419 | protein_coding | deleterious(0.02) | possibly_damaging(0.572) | TCGA-CR-7389-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | paclitaxel | CR |
CDC45 | deletion | In_Frame_Del | rs762283906 | c.1098_1100delNNN | p.Ser367del | p.S367del | O75419 | protein_coding | TCGA-CN-5369-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
CDC45 | SNV | Missense_Mutation | novel | c.1619N>A | p.Gly540Asp | p.G540D | O75419 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
CDC45 | SNV | Missense_Mutation | c.1022N>G | p.Lys341Arg | p.K341R | O75419 | protein_coding | deleterious(0.02) | possibly_damaging(0.688) | TCGA-BR-4280-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
CDC45 | SNV | Missense_Mutation | rs779593928 | c.841N>A | p.Val281Ile | p.V281I | O75419 | protein_coding | deleterious(0.01) | possibly_damaging(0.535) | TCGA-CD-A4MI-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | PD |
CDC45 | SNV | Missense_Mutation | c.1693A>G | p.Thr565Ala | p.T565A | O75419 | protein_coding | deleterious(0.01) | probably_damaging(0.983) | TCGA-HU-A4H8-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Chemotherapy | didox | PD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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