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Gene: CD177 |
Gene summary for CD177 |
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Gene information | Species | Human | Gene symbol | CD177 | Gene ID | 57126 |
Gene name | CD177 molecule | |
Gene Alias | HNA-2a | |
Cytomap | 19q13.31 | |
Gene Type | protein-coding | GO ID | GO:0001775 | UniProtAcc | A0A087WVM2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57126 | CD177 | HTA11_347_2000001011 | Human | Colorectum | AD | 3.14e-17 | 8.09e-01 | -0.1954 |
57126 | CD177 | HTA11_411_2000001011 | Human | Colorectum | SER | 3.11e-03 | 8.61e-01 | -0.2602 |
57126 | CD177 | HTA11_2112_2000001011 | Human | Colorectum | SER | 6.44e-04 | 7.97e-01 | -0.2196 |
57126 | CD177 | HTA11_696_2000001011 | Human | Colorectum | AD | 3.47e-09 | 3.79e-01 | -0.1464 |
57126 | CD177 | HTA11_5212_2000001011 | Human | Colorectum | AD | 4.46e-13 | 1.04e+00 | -0.2061 |
57126 | CD177 | A002-C-021 | Human | Colorectum | FAP | 1.09e-04 | 1.83e-01 | 0.1171 |
57126 | CD177 | P31T-E | Human | Esophagus | ESCC | 3.95e-30 | 1.24e+00 | 0.1251 |
57126 | CD177 | P61T-E | Human | Esophagus | ESCC | 7.45e-21 | 8.29e-01 | 0.099 |
57126 | CD177 | P84T-E | Human | Esophagus | ESCC | 8.33e-03 | 9.03e-01 | 0.0933 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0045216 | Colorectum | AD | cell-cell junction organization | 80/3918 | 200/18723 | 5.57e-10 | 4.58e-08 | 80 |
GO:0043954 | Colorectum | AD | cellular component maintenance | 26/3918 | 61/18723 | 1.04e-04 | 1.56e-03 | 26 |
GO:0030100 | Colorectum | AD | regulation of endocytosis | 67/3918 | 211/18723 | 1.42e-04 | 2.01e-03 | 67 |
GO:0045921 | Colorectum | AD | positive regulation of exocytosis | 33/3918 | 86/18723 | 1.58e-04 | 2.20e-03 | 33 |
GO:0072593 | Colorectum | AD | reactive oxygen species metabolic process | 73/3918 | 239/18723 | 2.79e-04 | 3.42e-03 | 73 |
GO:0051047 | Colorectum | AD | positive regulation of secretion | 90/3918 | 310/18723 | 4.11e-04 | 4.66e-03 | 90 |
GO:2000379 | Colorectum | AD | positive regulation of reactive oxygen species metabolic process | 29/3918 | 76/18723 | 4.31e-04 | 4.82e-03 | 29 |
GO:1903532 | Colorectum | AD | positive regulation of secretion by cell | 82/3918 | 282/18723 | 6.85e-04 | 7.00e-03 | 82 |
GO:0006887 | Colorectum | AD | exocytosis | 96/3918 | 352/18723 | 2.48e-03 | 1.90e-02 | 96 |
GO:2000377 | Colorectum | AD | regulation of reactive oxygen species metabolic process | 48/3918 | 157/18723 | 2.77e-03 | 2.09e-02 | 48 |
GO:0034331 | Colorectum | AD | cell junction maintenance | 15/3918 | 35/18723 | 2.78e-03 | 2.09e-02 | 15 |
GO:0017157 | Colorectum | AD | regulation of exocytosis | 59/3918 | 202/18723 | 3.20e-03 | 2.36e-02 | 59 |
GO:0034394 | Colorectum | AD | protein localization to cell surface | 24/3918 | 68/18723 | 4.33e-03 | 2.97e-02 | 24 |
GO:00452161 | Colorectum | SER | cell-cell junction organization | 63/2897 | 200/18723 | 9.15e-09 | 7.80e-07 | 63 |
GO:00725931 | Colorectum | SER | reactive oxygen species metabolic process | 61/2897 | 239/18723 | 3.63e-05 | 9.39e-04 | 61 |
GO:00439541 | Colorectum | SER | cellular component maintenance | 22/2897 | 61/18723 | 6.47e-05 | 1.49e-03 | 22 |
GO:20003791 | Colorectum | SER | positive regulation of reactive oxygen species metabolic process | 24/2897 | 76/18723 | 3.29e-04 | 5.22e-03 | 24 |
GO:20003771 | Colorectum | SER | regulation of reactive oxygen species metabolic process | 41/2897 | 157/18723 | 3.86e-04 | 5.86e-03 | 41 |
GO:00459211 | Colorectum | SER | positive regulation of exocytosis | 25/2897 | 86/18723 | 9.88e-04 | 1.17e-02 | 25 |
GO:00068871 | Colorectum | SER | exocytosis | 75/2897 | 352/18723 | 2.05e-03 | 2.03e-02 | 75 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CD177 | SNV | Missense_Mutation | rs550497658 | c.1189G>A | p.Asp397Asn | p.D397N | protein_coding | tolerated(0.29) | benign(0.007) | TCGA-D7-6528-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CD177 | SNV | Missense_Mutation | rs186991229 | c.715N>A | p.Glu239Lys | p.E239K | protein_coding | tolerated(0.3) | benign(0.056) | TCGA-IN-A6RL-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD | |
CD177 | SNV | Missense_Mutation | rs751529556 | c.1093N>G | p.Thr365Ala | p.T365A | protein_coding | tolerated(0.58) | benign(0.03) | TCGA-VQ-A91D-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | fluorouracil | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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