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Gene: CCNT2 |
Gene summary for CCNT2 |
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Gene information | Species | Human | Gene symbol | CCNT2 | Gene ID | 905 |
Gene name | cyclin T2 | |
Gene Alias | CYCT2 | |
Cytomap | 2q21.3 | |
Gene Type | protein-coding | GO ID | GO:0000079 | UniProtAcc | B4DH21 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
905 | CCNT2 | HTA11_3410_2000001011 | Human | Colorectum | AD | 8.46e-12 | -4.51e-01 | 0.0155 |
905 | CCNT2 | HTA11_2487_2000001011 | Human | Colorectum | SER | 3.43e-05 | -4.33e-01 | -0.1808 |
905 | CCNT2 | HTA11_2951_2000001011 | Human | Colorectum | AD | 2.86e-02 | -5.11e-01 | 0.0216 |
905 | CCNT2 | HTA11_3361_2000001011 | Human | Colorectum | AD | 7.46e-04 | -4.37e-01 | -0.1207 |
905 | CCNT2 | HTA11_696_2000001011 | Human | Colorectum | AD | 2.48e-11 | -3.81e-01 | -0.1464 |
905 | CCNT2 | HTA11_866_2000001011 | Human | Colorectum | AD | 2.18e-08 | -3.35e-01 | -0.1001 |
905 | CCNT2 | HTA11_1391_2000001011 | Human | Colorectum | AD | 3.36e-04 | -3.68e-01 | -0.059 |
905 | CCNT2 | HTA11_866_3004761011 | Human | Colorectum | AD | 5.61e-08 | -4.23e-01 | 0.096 |
905 | CCNT2 | HTA11_8622_2000001021 | Human | Colorectum | SER | 2.28e-04 | -5.11e-01 | 0.0528 |
905 | CCNT2 | HTA11_10711_2000001011 | Human | Colorectum | AD | 5.74e-05 | -4.37e-01 | 0.0338 |
905 | CCNT2 | HTA11_7696_3000711011 | Human | Colorectum | AD | 4.55e-11 | -3.75e-01 | 0.0674 |
905 | CCNT2 | HTA11_6818_2000001021 | Human | Colorectum | AD | 8.39e-03 | -4.17e-01 | 0.0588 |
905 | CCNT2 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 3.83e-03 | -2.52e-01 | 0.294 |
905 | CCNT2 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.96e-07 | -3.49e-01 | 0.3859 |
905 | CCNT2 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 1.83e-03 | -4.63e-01 | 0.2585 |
905 | CCNT2 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.52e-11 | -3.99e-01 | 0.3005 |
905 | CCNT2 | A001-C-207 | Human | Colorectum | FAP | 7.59e-04 | -2.82e-01 | 0.1278 |
905 | CCNT2 | A015-C-203 | Human | Colorectum | FAP | 3.70e-21 | -3.46e-01 | -0.1294 |
905 | CCNT2 | A015-C-204 | Human | Colorectum | FAP | 7.93e-03 | -2.19e-01 | -0.0228 |
905 | CCNT2 | A014-C-040 | Human | Colorectum | FAP | 3.09e-04 | -4.60e-01 | -0.1184 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0016032 | Colorectum | AD | viral process | 168/3918 | 415/18723 | 4.67e-20 | 3.66e-17 | 168 |
GO:0019080 | Colorectum | AD | viral gene expression | 42/3918 | 94/18723 | 1.90e-07 | 8.02e-06 | 42 |
GO:0033674 | Colorectum | AD | positive regulation of kinase activity | 131/3918 | 467/18723 | 1.28e-04 | 1.85e-03 | 131 |
GO:0045860 | Colorectum | AD | positive regulation of protein kinase activity | 107/3918 | 386/18723 | 8.01e-04 | 7.92e-03 | 107 |
GO:0032786 | Colorectum | AD | positive regulation of DNA-templated transcription, elongation | 13/3918 | 27/18723 | 1.47e-03 | 1.25e-02 | 13 |
GO:0071900 | Colorectum | AD | regulation of protein serine/threonine kinase activity | 98/3918 | 359/18723 | 2.18e-03 | 1.73e-02 | 98 |
GO:0006354 | Colorectum | AD | DNA-templated transcription, elongation | 31/3918 | 91/18723 | 2.46e-03 | 1.90e-02 | 31 |
GO:0071902 | Colorectum | AD | positive regulation of protein serine/threonine kinase activity | 58/3918 | 200/18723 | 4.09e-03 | 2.84e-02 | 58 |
GO:0045787 | Colorectum | AD | positive regulation of cell cycle | 85/3918 | 313/18723 | 4.76e-03 | 3.22e-02 | 85 |
GO:00160321 | Colorectum | SER | viral process | 118/2897 | 415/18723 | 8.36e-12 | 1.65e-09 | 118 |
GO:00190801 | Colorectum | SER | viral gene expression | 29/2897 | 94/18723 | 1.32e-04 | 2.66e-03 | 29 |
GO:00336741 | Colorectum | SER | positive regulation of kinase activity | 95/2897 | 467/18723 | 2.62e-03 | 2.41e-02 | 95 |
GO:00458601 | Colorectum | SER | positive regulation of protein kinase activity | 79/2897 | 386/18723 | 4.85e-03 | 3.79e-02 | 79 |
GO:00719001 | Colorectum | SER | regulation of protein serine/threonine kinase activity | 74/2897 | 359/18723 | 5.22e-03 | 3.96e-02 | 74 |
GO:00160322 | Colorectum | MSS | viral process | 157/3467 | 415/18723 | 7.94e-21 | 6.19e-18 | 157 |
GO:00190802 | Colorectum | MSS | viral gene expression | 41/3467 | 94/18723 | 1.74e-08 | 9.85e-07 | 41 |
GO:00336742 | Colorectum | MSS | positive regulation of kinase activity | 122/3467 | 467/18723 | 2.50e-05 | 5.21e-04 | 122 |
GO:00458602 | Colorectum | MSS | positive regulation of protein kinase activity | 102/3467 | 386/18723 | 6.93e-05 | 1.20e-03 | 102 |
GO:00719002 | Colorectum | MSS | regulation of protein serine/threonine kinase activity | 93/3467 | 359/18723 | 2.98e-04 | 3.91e-03 | 93 |
GO:00719021 | Colorectum | MSS | positive regulation of protein serine/threonine kinase activity | 55/3467 | 200/18723 | 1.12e-03 | 1.11e-02 | 55 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa03250 | Colorectum | MSS | Viral life cycle - HIV-1 | 23/1875 | 63/8465 | 6.55e-03 | 2.64e-02 | 1.62e-02 | 23 |
hsa032501 | Colorectum | MSS | Viral life cycle - HIV-1 | 23/1875 | 63/8465 | 6.55e-03 | 2.64e-02 | 1.62e-02 | 23 |
hsa05202 | Colorectum | FAP | Transcriptional misregulation in cancer | 45/1404 | 193/8465 | 9.19e-03 | 3.33e-02 | 2.03e-02 | 45 |
hsa052021 | Colorectum | FAP | Transcriptional misregulation in cancer | 45/1404 | 193/8465 | 9.19e-03 | 3.33e-02 | 2.03e-02 | 45 |
hsa032509 | Esophagus | ESCC | Viral life cycle - HIV-1 | 54/4205 | 63/8465 | 2.01e-09 | 2.17e-08 | 1.11e-08 | 54 |
hsa052028 | Esophagus | ESCC | Transcriptional misregulation in cancer | 116/4205 | 193/8465 | 2.08e-03 | 5.95e-03 | 3.05e-03 | 116 |
hsa0325014 | Esophagus | ESCC | Viral life cycle - HIV-1 | 54/4205 | 63/8465 | 2.01e-09 | 2.17e-08 | 1.11e-08 | 54 |
hsa0520213 | Esophagus | ESCC | Transcriptional misregulation in cancer | 116/4205 | 193/8465 | 2.08e-03 | 5.95e-03 | 3.05e-03 | 116 |
hsa032502 | Liver | HCC | Viral life cycle - HIV-1 | 46/4020 | 63/8465 | 3.25e-05 | 1.88e-04 | 1.04e-04 | 46 |
hsa0325011 | Liver | HCC | Viral life cycle - HIV-1 | 46/4020 | 63/8465 | 3.25e-05 | 1.88e-04 | 1.04e-04 | 46 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CCNT2 | SNV | Missense_Mutation | novel | c.889N>G | p.Thr297Ala | p.T297A | O60583 | protein_coding | tolerated(0.62) | benign(0) | TCGA-55-7995-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | CR |
CCNT2 | SNV | Missense_Mutation | novel | c.1634N>A | p.Ser545Asn | p.S545N | O60583 | protein_coding | tolerated(0.08) | benign(0.276) | TCGA-64-5781-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
CCNT2 | SNV | Missense_Mutation | novel | c.643N>G | p.Thr215Ala | p.T215A | O60583 | protein_coding | deleterious(0.01) | benign(0.007) | TCGA-NJ-A4YQ-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CCNT2 | SNV | Missense_Mutation | rs757139153 | c.1660N>G | p.Arg554Gly | p.R554G | O60583 | protein_coding | deleterious(0) | benign(0.024) | TCGA-22-4599-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CCNT2 | SNV | Missense_Mutation | novel | c.1682A>G | p.Lys561Arg | p.K561R | O60583 | protein_coding | tolerated(0.59) | benign(0.003) | TCGA-77-6845-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
CCNT2 | SNV | Missense_Mutation | rs762671853 | c.1871A>G | p.Asn624Ser | p.N624S | O60583 | protein_coding | tolerated(0.65) | benign(0.001) | TCGA-CV-A45U-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
CCNT2 | SNV | Missense_Mutation | novel | c.312N>G | p.Ile104Met | p.I104M | O60583 | protein_coding | deleterious(0) | probably_damaging(0.953) | TCGA-D6-A4ZB-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
CCNT2 | deletion | Frame_Shift_Del | novel | c.1404delG | p.Gln469SerfsTer16 | p.Q469Sfs*16 | O60583 | protein_coding | TCGA-CN-5360-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | SD | ||
CCNT2 | SNV | Missense_Mutation | novel | c.2056N>G | p.Lys686Glu | p.K686E | O60583 | protein_coding | deleterious(0) | benign(0.223) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
CCNT2 | SNV | Missense_Mutation | c.1835N>G | p.Ser612Cys | p.S612C | O60583 | protein_coding | deleterious(0.01) | possibly_damaging(0.818) | TCGA-BR-4369-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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