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Gene: CCDC112 |
Gene summary for CCDC112 |
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Gene information | Species | Human | Gene symbol | CCDC112 | Gene ID | 153733 |
Gene name | coiled-coil domain containing 112 | |
Gene Alias | MBC1 | |
Cytomap | 5q22.3 | |
Gene Type | protein-coding | GO ID | GO:0003674 | UniProtAcc | Q8NEF3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
153733 | CCDC112 | HTA11_347_2000001011 | Human | Colorectum | AD | 2.73e-03 | 3.52e-01 | -0.1954 |
153733 | CCDC112 | HTA11_696_2000001011 | Human | Colorectum | AD | 7.43e-06 | 3.15e-01 | -0.1464 |
153733 | CCDC112 | HTA11_6818_2000001011 | Human | Colorectum | AD | 8.90e-03 | 4.35e-01 | 0.0112 |
153733 | CCDC112 | A015-C-203 | Human | Colorectum | FAP | 1.27e-07 | -7.01e-02 | -0.1294 |
153733 | CCDC112 | A002-C-201 | Human | Colorectum | FAP | 3.63e-02 | -9.14e-02 | 0.0324 |
153733 | CCDC112 | A001-C-108 | Human | Colorectum | FAP | 9.78e-03 | -4.39e-02 | -0.0272 |
153733 | CCDC112 | A002-C-205 | Human | Colorectum | FAP | 5.14e-05 | -1.05e-01 | -0.1236 |
153733 | CCDC112 | A015-C-006 | Human | Colorectum | FAP | 1.74e-03 | -1.06e-01 | -0.0994 |
153733 | CCDC112 | A015-C-106 | Human | Colorectum | FAP | 2.06e-02 | -8.51e-02 | -0.0511 |
153733 | CCDC112 | A002-C-114 | Human | Colorectum | FAP | 1.33e-03 | -1.28e-01 | -0.1561 |
153733 | CCDC112 | A015-C-104 | Human | Colorectum | FAP | 2.78e-10 | -7.91e-02 | -0.1899 |
153733 | CCDC112 | A002-C-016 | Human | Colorectum | FAP | 8.25e-04 | -1.02e-01 | 0.0521 |
153733 | CCDC112 | A001-C-203 | Human | Colorectum | FAP | 5.87e-03 | 3.80e-02 | -0.0481 |
153733 | CCDC112 | A002-C-116 | Human | Colorectum | FAP | 9.13e-09 | -5.79e-02 | -0.0452 |
153733 | CCDC112 | A014-C-008 | Human | Colorectum | FAP | 1.64e-02 | -1.60e-01 | -0.191 |
153733 | CCDC112 | A018-E-020 | Human | Colorectum | FAP | 8.21e-04 | -6.26e-02 | -0.2034 |
153733 | CCDC112 | F034 | Human | Colorectum | FAP | 8.72e-05 | -1.17e-01 | -0.0665 |
153733 | CCDC112 | CRC-1-8810 | Human | Colorectum | CRC | 2.11e-02 | -2.32e-01 | 0.6257 |
153733 | CCDC112 | LZE24T | Human | Esophagus | ESCC | 4.67e-06 | 2.59e-01 | 0.0596 |
153733 | CCDC112 | P2T-E | Human | Esophagus | ESCC | 2.16e-09 | 2.21e-01 | 0.1177 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CCDC112 | SNV | Missense_Mutation | c.857N>G | p.Glu286Gly | p.E286G | Q8NEF3 | protein_coding | deleterious(0.01) | benign(0.385) | TCGA-KK-A59V-01 | Prostate | prostate adenocarcinoma | Male | <65 | 9 | Unknown | Unknown | SD | |
CCDC112 | SNV | Missense_Mutation | novel | c.634N>G | p.Phe212Val | p.F212V | Q8NEF3 | protein_coding | tolerated(0.45) | benign(0.009) | TCGA-HU-A4HB-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Chemotherapy | ts-1 | PD |
CCDC112 | insertion | Frame_Shift_Ins | novel | c.262_263insGAGAACAC | p.Lys88ArgfsTer22 | p.K88Rfs*22 | Q8NEF3 | protein_coding | TCGA-EL-A3ZG-01 | Thyroid | thyroid carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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