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Gene: CAPN15 |
Gene summary for CAPN15 |
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Gene information | Species | Human | Gene symbol | CAPN15 | Gene ID | 6650 |
Gene name | calpain 15 | |
Gene Alias | OGIN | |
Cytomap | 16p13.3 | |
Gene Type | protein-coding | GO ID | GO:0006508 | UniProtAcc | O75808 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6650 | CAPN15 | HCC1_Meng | Human | Liver | HCC | 1.28e-14 | 4.50e-03 | 0.0246 |
6650 | CAPN15 | HCC2_Meng | Human | Liver | HCC | 1.94e-09 | 9.11e-02 | 0.0107 |
6650 | CAPN15 | S014 | Human | Liver | HCC | 8.34e-17 | 5.54e-01 | 0.2254 |
6650 | CAPN15 | S015 | Human | Liver | HCC | 3.98e-16 | 6.35e-01 | 0.2375 |
6650 | CAPN15 | S016 | Human | Liver | HCC | 7.21e-20 | 6.44e-01 | 0.2243 |
6650 | CAPN15 | S027 | Human | Liver | HCC | 1.38e-11 | 7.34e-01 | 0.2446 |
6650 | CAPN15 | S028 | Human | Liver | HCC | 1.32e-22 | 6.67e-01 | 0.2503 |
6650 | CAPN15 | S029 | Human | Liver | HCC | 4.96e-14 | 5.38e-01 | 0.2581 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CAPN15 | SNV | Missense_Mutation | novel | c.1501N>A | p.Gly501Ser | p.G501S | O75808 | protein_coding | tolerated(0.46) | probably_damaging(1) | TCGA-CR-6481-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | paclitaxel | SD |
CAPN15 | SNV | Missense_Mutation | novel | c.155N>A | p.Arg52His | p.R52H | O75808 | protein_coding | tolerated_low_confidence(0.07) | probably_damaging(0.997) | TCGA-CR-7367-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | paclitaxel | SD |
CAPN15 | insertion | Frame_Shift_Ins | novel | c.2918_2919insGACC | p.Cys975AspfsTer30 | p.C975Dfs*30 | O75808 | protein_coding | TCGA-CR-7374-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
CAPN15 | deletion | In_Frame_Del | novel | c.1764_1766delNNN | p.Cys588_Lys589delinsTrp | p.C588_K589delinsW | O75808 | protein_coding | TCGA-CV-5436-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | ||
CAPN15 | SNV | Missense_Mutation | rs756826201 | c.2620N>T | p.Arg874Cys | p.R874C | O75808 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-J9-A52C-01 | Prostate | prostate adenocarcinoma | Male | <65 | 9 | Unknown | Unknown | SD |
CAPN15 | SNV | Missense_Mutation | novel | c.3119A>G | p.Asn1040Ser | p.N1040S | O75808 | protein_coding | tolerated(0.55) | probably_damaging(0.985) | TCGA-YL-A9WY-01 | Prostate | prostate adenocarcinoma | Male | <65 | 9 | Hormone Therapy | casodex | PD |
CAPN15 | SNV | Missense_Mutation | c.3228N>T | p.Glu1076Asp | p.E1076D | O75808 | protein_coding | tolerated(0.69) | benign(0.001) | TCGA-BR-4280-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
CAPN15 | SNV | Missense_Mutation | c.2330N>G | p.Tyr777Cys | p.Y777C | O75808 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-BR-4361-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
CAPN15 | SNV | Missense_Mutation | c.2908N>T | p.Arg970Cys | p.R970C | O75808 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-D7-A4YV-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CAPN15 | SNV | Missense_Mutation | c.2236N>A | p.Gly746Ser | p.G746S | O75808 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-F1-6874-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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