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Gene: CACHD1 |
Gene summary for CACHD1 |
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Gene information | Species | Human | Gene symbol | CACHD1 | Gene ID | 57685 |
Gene name | cache domain containing 1 | |
Gene Alias | CACHD1 | |
Cytomap | 1p31.3 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q5VU97 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57685 | CACHD1 | AEH-subject1 | Human | Endometrium | AEH | 6.22e-12 | 3.93e-01 | -0.3059 |
57685 | CACHD1 | AEH-subject2 | Human | Endometrium | AEH | 2.36e-06 | 3.14e-01 | -0.2525 |
57685 | CACHD1 | AEH-subject3 | Human | Endometrium | AEH | 1.52e-14 | 4.95e-01 | -0.2576 |
57685 | CACHD1 | AEH-subject4 | Human | Endometrium | AEH | 1.82e-08 | 4.51e-01 | -0.2657 |
57685 | CACHD1 | AEH-subject5 | Human | Endometrium | AEH | 1.41e-05 | 3.78e-01 | -0.2953 |
57685 | CACHD1 | EEC-subject1 | Human | Endometrium | EEC | 3.19e-14 | 5.16e-01 | -0.2682 |
57685 | CACHD1 | EEC-subject2 | Human | Endometrium | EEC | 8.90e-07 | 3.38e-01 | -0.2607 |
57685 | CACHD1 | EEC-subject3 | Human | Endometrium | EEC | 1.46e-03 | 1.97e-01 | -0.2525 |
57685 | CACHD1 | EEC-subject4 | Human | Endometrium | EEC | 7.11e-06 | 3.04e-01 | -0.2571 |
57685 | CACHD1 | EEC-subject5 | Human | Endometrium | EEC | 3.94e-06 | 3.15e-01 | -0.249 |
57685 | CACHD1 | GSM6177620_NYU_UCEC1_lib1_lib1 | Human | Endometrium | EEC | 6.56e-09 | 3.76e-02 | -0.1869 |
57685 | CACHD1 | GSM6177620_NYU_UCEC1_lib2_lib2 | Human | Endometrium | EEC | 2.55e-06 | -1.45e-02 | -0.1875 |
57685 | CACHD1 | GSM6177620_NYU_UCEC1_lib3_lib3 | Human | Endometrium | EEC | 1.11e-10 | 1.13e-01 | -0.1883 |
57685 | CACHD1 | GSM6177621_NYU_UCEC2_lib1_lib1 | Human | Endometrium | EEC | 4.18e-04 | 1.01e-01 | -0.1934 |
57685 | CACHD1 | GSM6177622_NYU_UCEC3_lib1_lib1 | Human | Endometrium | EEC | 9.36e-07 | -3.64e-02 | -0.1917 |
57685 | CACHD1 | GSM6177622_NYU_UCEC3_lib2_lib2 | Human | Endometrium | EEC | 2.83e-10 | -4.13e-02 | -0.1916 |
57685 | CACHD1 | GSM6177623_NYU_UCEC3_Vis | Human | Endometrium | EEC | 3.37e-02 | 2.16e-01 | -0.1269 |
57685 | CACHD1 | HCC2 | Human | Liver | HCC | 1.41e-05 | 3.64e+00 | 0.5341 |
57685 | CACHD1 | S014 | Human | Liver | HCC | 6.93e-25 | 7.43e-01 | 0.2254 |
57685 | CACHD1 | S015 | Human | Liver | HCC | 3.28e-20 | 9.28e-01 | 0.2375 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006816 | Lung | AIS | calcium ion transport | 58/1849 | 422/18723 | 6.08e-03 | 4.98e-02 | 58 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CACHD1 | SNV | Missense_Mutation | novel | c.1906G>A | p.Asp636Asn | p.D636N | protein_coding | deleterious(0) | probably_damaging(0.972) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
CACHD1 | SNV | Missense_Mutation | novel | c.2269A>G | p.Met757Val | p.M757V | protein_coding | tolerated(0.28) | possibly_damaging(0.685) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
CACHD1 | SNV | Missense_Mutation | novel | c.3437A>G | p.Tyr1146Cys | p.Y1146C | protein_coding | deleterious(0) | probably_damaging(0.984) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
CACHD1 | SNV | Missense_Mutation | c.527A>C | p.Lys176Thr | p.K176T | protein_coding | tolerated(0.07) | probably_damaging(0.954) | TCGA-EI-6507-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | ||
CACHD1 | SNV | Missense_Mutation | novel | c.992N>T | p.Ala331Val | p.A331V | protein_coding | tolerated(0.22) | probably_damaging(0.956) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD | |
CACHD1 | SNV | Missense_Mutation | rs772296106 | c.308G>A | p.Arg103Gln | p.R103Q | protein_coding | tolerated(0.48) | probably_damaging(0.968) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
CACHD1 | insertion | Frame_Shift_Ins | rs764948820 | c.3551dupC | p.Gln1185SerfsTer23 | p.Q1185Sfs*23 | protein_coding | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
CACHD1 | insertion | Frame_Shift_Ins | novel | c.803dupA | p.Ala269GlyfsTer11 | p.A269Gfs*11 | protein_coding | TCGA-A6-5665-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |||
CACHD1 | insertion | Frame_Shift_Ins | rs764948820 | c.3544_3545insC | p.Gln1185SerfsTer23 | p.Q1185Sfs*23 | protein_coding | TCGA-AA-3877-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
CACHD1 | insertion | Frame_Shift_Ins | novel | c.1068_1069insCAAAATGGTT | p.Tyr357GlnfsTer16 | p.Y357Qfs*16 | protein_coding | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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