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Gene: CABIN1 |
Gene summary for CABIN1 |
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Gene information | Species | Human | Gene symbol | CABIN1 | Gene ID | 23523 |
Gene name | calcineurin binding protein 1 | |
Gene Alias | CAIN | |
Cytomap | 22q11.23 | |
Gene Type | protein-coding | GO ID | GO:0006323 | UniProtAcc | A0A024R1E5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23523 | CABIN1 | LZE4T | Human | Esophagus | ESCC | 3.87e-08 | 1.64e-01 | 0.0811 |
23523 | CABIN1 | LZE7T | Human | Esophagus | ESCC | 2.63e-05 | 3.35e-01 | 0.0667 |
23523 | CABIN1 | LZE24T | Human | Esophagus | ESCC | 1.22e-04 | 1.98e-01 | 0.0596 |
23523 | CABIN1 | LZE6T | Human | Esophagus | ESCC | 1.87e-04 | 2.02e-01 | 0.0845 |
23523 | CABIN1 | P1T-E | Human | Esophagus | ESCC | 1.79e-08 | 3.67e-01 | 0.0875 |
23523 | CABIN1 | P2T-E | Human | Esophagus | ESCC | 7.26e-15 | 2.67e-01 | 0.1177 |
23523 | CABIN1 | P4T-E | Human | Esophagus | ESCC | 4.60e-12 | 2.55e-01 | 0.1323 |
23523 | CABIN1 | P5T-E | Human | Esophagus | ESCC | 2.18e-12 | 1.36e-01 | 0.1327 |
23523 | CABIN1 | P8T-E | Human | Esophagus | ESCC | 4.79e-09 | 1.31e-01 | 0.0889 |
23523 | CABIN1 | P9T-E | Human | Esophagus | ESCC | 1.49e-15 | 3.31e-01 | 0.1131 |
23523 | CABIN1 | P10T-E | Human | Esophagus | ESCC | 5.16e-24 | 3.02e-01 | 0.116 |
23523 | CABIN1 | P11T-E | Human | Esophagus | ESCC | 6.90e-03 | 1.59e-01 | 0.1426 |
23523 | CABIN1 | P12T-E | Human | Esophagus | ESCC | 1.26e-09 | 2.17e-01 | 0.1122 |
23523 | CABIN1 | P15T-E | Human | Esophagus | ESCC | 1.64e-21 | 5.30e-01 | 0.1149 |
23523 | CABIN1 | P16T-E | Human | Esophagus | ESCC | 3.30e-19 | 3.99e-01 | 0.1153 |
23523 | CABIN1 | P17T-E | Human | Esophagus | ESCC | 3.20e-02 | 1.58e-01 | 0.1278 |
23523 | CABIN1 | P20T-E | Human | Esophagus | ESCC | 5.70e-08 | 1.36e-01 | 0.1124 |
23523 | CABIN1 | P21T-E | Human | Esophagus | ESCC | 9.04e-17 | 1.87e-01 | 0.1617 |
23523 | CABIN1 | P22T-E | Human | Esophagus | ESCC | 5.84e-19 | 3.27e-01 | 0.1236 |
23523 | CABIN1 | P23T-E | Human | Esophagus | ESCC | 1.58e-11 | 2.95e-01 | 0.108 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000632517 | Esophagus | ESCC | chromatin organization | 240/8552 | 409/18723 | 6.52e-08 | 1.14e-06 | 240 |
GO:00063255 | Liver | NAFLD | chromatin organization | 64/1882 | 409/18723 | 2.31e-04 | 3.89e-03 | 64 |
GO:000632511 | Liver | HCC | chromatin organization | 206/7958 | 409/18723 | 7.23e-04 | 4.41e-03 | 206 |
GO:000632520 | Thyroid | PTC | chromatin organization | 183/5968 | 409/18723 | 2.55e-08 | 5.70e-07 | 183 |
GO:00063385 | Thyroid | PTC | chromatin remodeling | 106/5968 | 255/18723 | 6.56e-04 | 4.13e-03 | 106 |
GO:0006325110 | Thyroid | ATC | chromatin organization | 189/6293 | 409/18723 | 6.40e-08 | 1.13e-06 | 189 |
GO:000633813 | Thyroid | ATC | chromatin remodeling | 109/6293 | 255/18723 | 1.38e-03 | 7.15e-03 | 109 |
GO:00718242 | Thyroid | ATC | protein-DNA complex subunit organization | 103/6293 | 241/18723 | 1.84e-03 | 9.03e-03 | 103 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CABIN1 | SNV | Missense_Mutation | c.5885C>T | p.Ala1962Val | p.A1962V | Q9Y6J0 | protein_coding | tolerated_low_confidence(0.3) | benign(0.006) | TCGA-CK-5916-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
CABIN1 | SNV | Missense_Mutation | c.5837N>T | p.Thr1946Ile | p.T1946I | Q9Y6J0 | protein_coding | tolerated_low_confidence(0.19) | benign(0.01) | TCGA-CM-4743-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | capecitabine | SD | |
CABIN1 | SNV | Missense_Mutation | novel | c.4006N>C | p.Ser1336Pro | p.S1336P | Q9Y6J0 | protein_coding | tolerated(0.09) | benign(0.003) | TCGA-G4-6628-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
CABIN1 | SNV | Missense_Mutation | c.3236N>C | p.Met1079Thr | p.M1079T | Q9Y6J0 | protein_coding | deleterious(0.02) | possibly_damaging(0.468) | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CABIN1 | SNV | Missense_Mutation | c.3065N>A | p.Pro1022Gln | p.P1022Q | Q9Y6J0 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AF-4110-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Chemotherapy | oxaliplatin | SD | |
CABIN1 | SNV | Missense_Mutation | rs568317451 | c.4078N>A | p.Val1360Ile | p.V1360I | Q9Y6J0 | protein_coding | tolerated(0.31) | benign(0.01) | TCGA-AG-4005-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folinic | CR |
CABIN1 | SNV | Missense_Mutation | rs750428201 | c.523N>G | p.Thr175Ala | p.T175A | Q9Y6J0 | protein_coding | tolerated(0.16) | benign(0.013) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CABIN1 | SNV | Missense_Mutation | novel | c.787N>A | p.Gln263Lys | p.Q263K | Q9Y6J0 | protein_coding | tolerated(0.19) | benign(0.056) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CABIN1 | SNV | Missense_Mutation | novel | c.4066N>A | p.Asp1356Asn | p.D1356N | Q9Y6J0 | protein_coding | tolerated(0.06) | probably_damaging(0.996) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CABIN1 | SNV | Missense_Mutation | rs573408065 | c.872G>A | p.Arg291His | p.R291H | Q9Y6J0 | protein_coding | deleterious(0.01) | probably_damaging(0.966) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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