|
Gene: C9orf3 |
Gene summary for C9ORF3 |
Gene summary. |
Gene information | Species | Human | Gene symbol | C9orf3 | Gene ID | 84909 |
Gene name | aminopeptidase O (putative) | |
Gene Alias | AP-O | |
Cytomap | 9q22.32 | |
Gene Type | protein-coding | GO ID | GO:0006508 | UniProtAcc | Q8N6M6 |
Top |
Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84909 | C9orf3 | HTA11_3410_2000001011 | Human | Colorectum | AD | 3.01e-58 | -1.08e+00 | 0.0155 |
84909 | C9orf3 | HTA11_2487_2000001011 | Human | Colorectum | SER | 7.31e-37 | -1.08e+00 | -0.1808 |
84909 | C9orf3 | HTA11_2951_2000001011 | Human | Colorectum | AD | 6.03e-11 | -1.08e+00 | 0.0216 |
84909 | C9orf3 | HTA11_1938_2000001011 | Human | Colorectum | AD | 3.94e-29 | -1.08e+00 | -0.0811 |
84909 | C9orf3 | HTA11_78_2000001011 | Human | Colorectum | AD | 1.81e-42 | -1.08e+00 | -0.1088 |
84909 | C9orf3 | HTA11_347_2000001011 | Human | Colorectum | AD | 5.01e-62 | -1.08e+00 | -0.1954 |
84909 | C9orf3 | HTA11_411_2000001011 | Human | Colorectum | SER | 1.87e-07 | -1.08e+00 | -0.2602 |
84909 | C9orf3 | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.07e-09 | -1.08e+00 | -0.2196 |
84909 | C9orf3 | HTA11_3361_2000001011 | Human | Colorectum | AD | 4.38e-30 | -1.08e+00 | -0.1207 |
84909 | C9orf3 | HTA11_83_2000001011 | Human | Colorectum | SER | 6.19e-25 | -1.08e+00 | -0.1526 |
84909 | C9orf3 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.72e-68 | -1.08e+00 | -0.1464 |
84909 | C9orf3 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.20e-62 | -1.08e+00 | -0.1001 |
84909 | C9orf3 | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.03e-48 | -1.08e+00 | -0.059 |
84909 | C9orf3 | HTA11_2992_2000001011 | Human | Colorectum | SER | 2.23e-13 | -1.08e+00 | -0.1706 |
84909 | C9orf3 | HTA11_5212_2000001011 | Human | Colorectum | AD | 3.78e-15 | -1.08e+00 | -0.2061 |
84909 | C9orf3 | HTA11_5216_2000001011 | Human | Colorectum | SER | 6.03e-11 | -1.08e+00 | -0.1462 |
84909 | C9orf3 | HTA11_546_2000001011 | Human | Colorectum | AD | 4.39e-22 | -1.08e+00 | -0.0842 |
84909 | C9orf3 | HTA11_9341_2000001011 | Human | Colorectum | SER | 1.87e-07 | -1.08e+00 | -0.00410000000000005 |
84909 | C9orf3 | HTA11_7862_2000001011 | Human | Colorectum | AD | 1.46e-18 | -1.08e+00 | -0.0179 |
84909 | C9orf3 | HTA11_866_3004761011 | Human | Colorectum | AD | 3.41e-52 | -1.08e+00 | 0.096 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 |
Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
C9orf3 | SNV | Missense_Mutation | c.566G>T | p.Arg189Leu | p.R189L | Q8N6M6 | protein_coding | deleterious(0.02) | benign(0.024) | TCGA-50-6594-01 | Lung | lung adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
C9orf3 | SNV | Missense_Mutation | c.263N>A | p.Arg88Lys | p.R88K | Q8N6M6 | protein_coding | tolerated_low_confidence(0.37) | benign(0) | TCGA-55-6985-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
C9orf3 | SNV | Missense_Mutation | c.834N>G | p.Asn278Lys | p.N278K | Q8N6M6 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-55-7570-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
C9orf3 | SNV | Missense_Mutation | novel | c.935A>G | p.Asn312Ser | p.N312S | Q8N6M6 | protein_coding | deleterious(0.04) | benign(0.338) | TCGA-55-8302-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
C9orf3 | SNV | Missense_Mutation | novel | c.310N>C | p.Lys104Gln | p.K104Q | Q8N6M6 | protein_coding | deleterious(0.01) | benign(0.05) | TCGA-MN-A4N1-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
C9orf3 | SNV | Missense_Mutation | c.2357G>T | p.Ser786Ile | p.S786I | Q8N6M6 | protein_coding | deleterious(0) | possibly_damaging(0.863) | TCGA-18-3416-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
C9orf3 | SNV | Missense_Mutation | c.794N>T | p.Gly265Val | p.G265V | Q8N6M6 | protein_coding | deleterious(0) | possibly_damaging(0.835) | TCGA-33-4533-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
C9orf3 | SNV | Missense_Mutation | c.2242C>T | p.Arg748Trp | p.R748W | Q8N6M6 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-39-5031-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
C9orf3 | SNV | Missense_Mutation | c.272C>T | p.Ser91Leu | p.S91L | Q8N6M6 | protein_coding | deleterious(0.05) | benign(0.282) | TCGA-NC-A5HG-01 | Lung | lung squamous cell carcinoma | Male | <65 | III/IV | Chemotherapy | cisplatin | CR | |
C9orf3 | deletion | Frame_Shift_Del | c.269delT | p.Phe90SerfsTer55 | p.F90Sfs*55 | Q8N6M6 | protein_coding | TCGA-05-4422-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 |
Top |
Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |