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Gene: BZW1 |
Gene summary for BZW1 |
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Gene information | Species | Human | Gene symbol | BZW1 | Gene ID | 9689 |
Gene name | basic leucine zipper and W2 domains 1 | |
Gene Alias | BZAP45 | |
Cytomap | 2q33.1 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | A0A024R3Z6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9689 | BZW1 | GSM4909282 | Human | Breast | IDC | 4.08e-04 | -3.58e-01 | -0.0288 |
9689 | BZW1 | GSM4909286 | Human | Breast | IDC | 1.46e-15 | -4.78e-01 | 0.1081 |
9689 | BZW1 | GSM4909293 | Human | Breast | IDC | 5.40e-03 | 4.55e-02 | 0.1581 |
9689 | BZW1 | GSM4909296 | Human | Breast | IDC | 1.62e-12 | -3.71e-01 | 0.1524 |
9689 | BZW1 | GSM4909297 | Human | Breast | IDC | 4.38e-12 | -1.52e-01 | 0.1517 |
9689 | BZW1 | GSM4909298 | Human | Breast | IDC | 1.40e-04 | -3.25e-01 | 0.1551 |
9689 | BZW1 | GSM4909302 | Human | Breast | IDC | 2.48e-13 | -4.93e-01 | 0.1545 |
9689 | BZW1 | GSM4909304 | Human | Breast | IDC | 1.15e-02 | 1.85e-01 | 0.1636 |
9689 | BZW1 | GSM4909309 | Human | Breast | IDC | 2.20e-10 | -4.44e-01 | 0.0483 |
9689 | BZW1 | GSM4909311 | Human | Breast | IDC | 1.94e-39 | -5.26e-01 | 0.1534 |
9689 | BZW1 | GSM4909312 | Human | Breast | IDC | 4.24e-12 | -3.19e-01 | 0.1552 |
9689 | BZW1 | GSM4909319 | Human | Breast | IDC | 4.06e-43 | -6.31e-01 | 0.1563 |
9689 | BZW1 | GSM4909320 | Human | Breast | IDC | 1.22e-10 | -5.86e-01 | 0.1575 |
9689 | BZW1 | GSM4909321 | Human | Breast | IDC | 1.17e-31 | -6.02e-01 | 0.1559 |
9689 | BZW1 | ctrl6 | Human | Breast | Precancer | 1.83e-03 | 4.50e-01 | -0.0061 |
9689 | BZW1 | brca2 | Human | Breast | Precancer | 4.97e-06 | 2.85e-01 | -0.024 |
9689 | BZW1 | brca3 | Human | Breast | Precancer | 3.00e-03 | 2.63e-01 | -0.0263 |
9689 | BZW1 | NCCBC14 | Human | Breast | DCIS | 6.86e-17 | 2.74e-01 | 0.2021 |
9689 | BZW1 | NCCBC2 | Human | Breast | DCIS | 2.58e-02 | -4.08e-01 | 0.1554 |
9689 | BZW1 | NCCBC5 | Human | Breast | DCIS | 4.03e-12 | -5.31e-02 | 0.2046 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
BZW1 | SNV | Missense_Mutation | novel | c.857N>A | p.Arg286His | p.R286H | Q7L1Q6 | protein_coding | deleterious(0) | possibly_damaging(0.572) | TCGA-CN-A63T-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | CR |
BZW1 | SNV | Missense_Mutation | novel | c.316N>G | p.Leu106Val | p.L106V | Q7L1Q6 | protein_coding | deleterious(0) | probably_damaging(0.931) | TCGA-CN-A6V1-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Immunotherapy | erbitux | CR |
BZW1 | insertion | Frame_Shift_Ins | rs774640795 | c.942_943insA | p.Asn317LysfsTer54 | p.N317Kfs*54 | Q7L1Q6 | protein_coding | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD | ||
BZW1 | SNV | Missense_Mutation | c.1280N>C | p.Glu427Ala | p.E427A | Q7L1Q6 | protein_coding | deleterious(0.01) | benign(0.335) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
BZW1 | SNV | Missense_Mutation | c.605G>A | p.Ser202Asn | p.S202N | Q7L1Q6 | protein_coding | tolerated(0.3) | benign(0.015) | TCGA-CG-4465-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | cisplatin | SD | |
BZW1 | SNV | Missense_Mutation | c.1252N>A | p.Val418Ile | p.V418I | Q7L1Q6 | protein_coding | tolerated(0.34) | benign(0.013) | TCGA-HU-A4G8-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | 5-fluorouracil | SD | |
BZW1 | SNV | Missense_Mutation | c.902A>G | p.Asp301Gly | p.D301G | Q7L1Q6 | protein_coding | tolerated(0.39) | benign(0.001) | TCGA-HU-A4GT-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | copolang | SD | |
BZW1 | SNV | Missense_Mutation | novel | c.802N>A | p.Ala268Thr | p.A268T | Q7L1Q6 | protein_coding | tolerated(0.25) | benign(0.197) | TCGA-HU-A4H8-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Chemotherapy | didox | PD |
BZW1 | deletion | Frame_Shift_Del | c.950delA | p.Asn317ThrfsTer11 | p.N317Tfs*11 | Q7L1Q6 | protein_coding | TCGA-BR-4362-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
BZW1 | deletion | Frame_Shift_Del | c.943delN | p.Asn317ThrfsTer11 | p.N317Tfs*11 | Q7L1Q6 | protein_coding | TCGA-BR-6802-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Ancillary | leucovorin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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