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Gene: BTNL3 |
Gene summary for BTNL3 |
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Gene information | Species | Human | Gene symbol | BTNL3 | Gene ID | 10917 |
Gene name | butyrophilin like 3 | |
Gene Alias | BTN9.1 | |
Cytomap | 5q35.3 | |
Gene Type | protein-coding | GO ID | GO:0001816 | UniProtAcc | Q6UXE8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10917 | BTNL3 | HTA11_3410_2000001011 | Human | Colorectum | AD | 4.24e-05 | -2.33e-01 | 0.0155 |
10917 | BTNL3 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.50e-02 | 5.27e-01 | -0.1808 |
10917 | BTNL3 | HTA11_78_2000001011 | Human | Colorectum | AD | 1.86e-02 | 4.34e-01 | -0.1088 |
10917 | BTNL3 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.81e-05 | 4.50e-01 | -0.1954 |
10917 | BTNL3 | HTA11_411_2000001011 | Human | Colorectum | SER | 1.62e-02 | 1.12e+00 | -0.2602 |
10917 | BTNL3 | HTA11_83_2000001011 | Human | Colorectum | SER | 1.92e-03 | 5.99e-01 | -0.1526 |
10917 | BTNL3 | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.29e-03 | -2.44e-01 | 0.0338 |
10917 | BTNL3 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 3.60e-05 | -2.35e-01 | 0.3005 |
10917 | BTNL3 | A001-C-207 | Human | Colorectum | FAP | 4.69e-04 | -2.36e-01 | 0.1278 |
10917 | BTNL3 | A015-C-203 | Human | Colorectum | FAP | 1.50e-06 | -2.34e-01 | -0.1294 |
10917 | BTNL3 | A002-C-201 | Human | Colorectum | FAP | 1.06e-02 | -1.51e-01 | 0.0324 |
10917 | BTNL3 | A002-C-203 | Human | Colorectum | FAP | 1.37e-02 | -1.50e-01 | 0.2786 |
10917 | BTNL3 | A001-C-119 | Human | Colorectum | FAP | 5.17e-05 | -2.44e-01 | -0.1557 |
10917 | BTNL3 | A001-C-108 | Human | Colorectum | FAP | 1.63e-03 | -1.88e-01 | -0.0272 |
10917 | BTNL3 | A002-C-205 | Human | Colorectum | FAP | 1.92e-09 | -2.44e-01 | -0.1236 |
10917 | BTNL3 | A001-C-104 | Human | Colorectum | FAP | 2.37e-07 | -2.16e-01 | 0.0184 |
10917 | BTNL3 | A015-C-005 | Human | Colorectum | FAP | 2.87e-03 | -1.97e-01 | -0.0336 |
10917 | BTNL3 | A015-C-006 | Human | Colorectum | FAP | 9.07e-06 | -2.44e-01 | -0.0994 |
10917 | BTNL3 | A015-C-106 | Human | Colorectum | FAP | 2.65e-02 | -1.85e-01 | -0.0511 |
10917 | BTNL3 | A002-C-114 | Human | Colorectum | FAP | 4.19e-04 | -1.90e-01 | -0.1561 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
BTNL3 | deletion | Frame_Shift_Del | c.1200delC | p.Ser401AlafsTer7 | p.S401Afs*7 | Q6UXE8 | protein_coding | TCGA-21-1080-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |||
BTNL3 | insertion | Frame_Shift_Ins | rs757227190 | c.1193_1194insC | p.Ser401GlnfsTer14 | p.S401Qfs*14 | Q6UXE8 | protein_coding | TCGA-34-2600-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
BTNL3 | SNV | Missense_Mutation | novel | c.874C>A | p.Leu292Met | p.L292M | Q6UXE8 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-CN-5356-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
BTNL3 | SNV | Missense_Mutation | c.971G>C | p.Arg324Thr | p.R324T | Q6UXE8 | protein_coding | deleterious(0.02) | probably_damaging(0.987) | TCGA-CQ-7071-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
BTNL3 | SNV | Missense_Mutation | novel | c.412N>G | p.Pro138Ala | p.P138A | Q6UXE8 | protein_coding | deleterious(0.01) | possibly_damaging(0.86) | TCGA-CR-7402-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | SD |
BTNL3 | SNV | Missense_Mutation | novel | c.443N>A | p.Gly148Glu | p.G148E | Q6UXE8 | protein_coding | tolerated(0.09) | possibly_damaging(0.563) | TCGA-CV-7568-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
BTNL3 | SNV | Missense_Mutation | rs200172568 | c.896N>T | p.Pro299Leu | p.P299L | Q6UXE8 | protein_coding | deleterious(0.02) | probably_damaging(0.999) | TCGA-UF-A7JS-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
BTNL3 | insertion | Frame_Shift_Ins | novel | c.69_70insCC | p.Gly25ArgfsTer65 | p.G25Rfs*65 | Q6UXE8 | protein_coding | TCGA-QK-A6IJ-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | ||
BTNL3 | SNV | Missense_Mutation | rs200172568 | c.896N>T | p.Pro299Leu | p.P299L | Q6UXE8 | protein_coding | deleterious(0.02) | probably_damaging(0.999) | TCGA-CH-5768-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 6 | Unknown | Unknown | SD |
BTNL3 | SNV | Missense_Mutation | c.1132N>C | p.Trp378Arg | p.W378R | Q6UXE8 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BR-7851-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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