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Gene: BRWD1 |
Gene summary for BRWD1 |
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Gene information | Species | Human | Gene symbol | BRWD1 | Gene ID | 54014 |
Gene name | bromodomain and WD repeat domain containing 1 | |
Gene Alias | C21orf107 | |
Cytomap | 21q22.2 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | Q9NSI6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54014 | BRWD1 | CA_HPV_1 | Human | Cervix | CC | 2.64e-02 | -7.70e-02 | 0.0264 |
54014 | BRWD1 | CCI_1 | Human | Cervix | CC | 2.95e-03 | 6.92e-01 | 0.528 |
54014 | BRWD1 | CCI_2 | Human | Cervix | CC | 3.70e-05 | 1.05e+00 | 0.5249 |
54014 | BRWD1 | CCI_3 | Human | Cervix | CC | 5.42e-10 | 1.00e+00 | 0.516 |
54014 | BRWD1 | sample3 | Human | Cervix | CC | 6.78e-03 | 1.09e-01 | 0.1387 |
54014 | BRWD1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 5.64e-30 | -8.05e-01 | 0.0155 |
54014 | BRWD1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 3.75e-12 | -6.19e-01 | -0.1808 |
54014 | BRWD1 | HTA11_2951_2000001011 | Human | Colorectum | AD | 4.17e-05 | -8.09e-01 | 0.0216 |
54014 | BRWD1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 4.06e-09 | -7.29e-01 | -0.1207 |
54014 | BRWD1 | HTA11_83_2000001011 | Human | Colorectum | SER | 9.04e-06 | -6.01e-01 | -0.1526 |
54014 | BRWD1 | HTA11_696_2000001011 | Human | Colorectum | AD | 4.77e-13 | -4.59e-01 | -0.1464 |
54014 | BRWD1 | HTA11_866_2000001011 | Human | Colorectum | AD | 9.56e-08 | -3.94e-01 | -0.1001 |
54014 | BRWD1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 9.37e-11 | -6.16e-01 | -0.059 |
54014 | BRWD1 | HTA11_5212_2000001011 | Human | Colorectum | AD | 6.21e-04 | -7.46e-01 | -0.2061 |
54014 | BRWD1 | HTA11_5216_2000001011 | Human | Colorectum | SER | 8.54e-03 | -7.81e-01 | -0.1462 |
54014 | BRWD1 | HTA11_546_2000001011 | Human | Colorectum | AD | 6.03e-08 | -7.56e-01 | -0.0842 |
54014 | BRWD1 | HTA11_7862_2000001011 | Human | Colorectum | AD | 3.14e-02 | -5.04e-01 | -0.0179 |
54014 | BRWD1 | HTA11_866_3004761011 | Human | Colorectum | AD | 4.74e-12 | -5.93e-01 | 0.096 |
54014 | BRWD1 | HTA11_8622_2000001021 | Human | Colorectum | SER | 3.53e-06 | -7.05e-01 | 0.0528 |
54014 | BRWD1 | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.94e-04 | -4.51e-01 | 0.0338 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:002260410 | Cervix | CC | regulation of cell morphogenesis | 84/2311 | 309/18723 | 1.00e-12 | 4.29e-10 | 84 |
GO:00083608 | Cervix | CC | regulation of cell shape | 38/2311 | 154/18723 | 1.86e-05 | 3.46e-04 | 38 |
GO:0022604 | Colorectum | AD | regulation of cell morphogenesis | 109/3918 | 309/18723 | 3.08e-09 | 2.07e-07 | 109 |
GO:0008360 | Colorectum | AD | regulation of cell shape | 56/3918 | 154/18723 | 7.01e-06 | 1.73e-04 | 56 |
GO:00226041 | Colorectum | SER | regulation of cell morphogenesis | 89/2897 | 309/18723 | 1.51e-09 | 1.52e-07 | 89 |
GO:00083601 | Colorectum | SER | regulation of cell shape | 43/2897 | 154/18723 | 5.47e-05 | 1.30e-03 | 43 |
GO:00226042 | Colorectum | MSS | regulation of cell morphogenesis | 103/3467 | 309/18723 | 2.70e-10 | 2.56e-08 | 103 |
GO:00083602 | Colorectum | MSS | regulation of cell shape | 52/3467 | 154/18723 | 4.40e-06 | 1.24e-04 | 52 |
GO:00226044 | Colorectum | FAP | regulation of cell morphogenesis | 87/2622 | 309/18723 | 4.89e-11 | 1.87e-08 | 87 |
GO:00083603 | Colorectum | FAP | regulation of cell shape | 43/2622 | 154/18723 | 4.55e-06 | 1.52e-04 | 43 |
GO:00226045 | Colorectum | CRC | regulation of cell morphogenesis | 74/2078 | 309/18723 | 9.25e-11 | 5.04e-08 | 74 |
GO:00083604 | Colorectum | CRC | regulation of cell shape | 38/2078 | 154/18723 | 1.51e-06 | 8.15e-05 | 38 |
GO:002260420 | Esophagus | ESCC | regulation of cell morphogenesis | 180/8552 | 309/18723 | 5.19e-06 | 5.45e-05 | 180 |
GO:000836018 | Esophagus | ESCC | regulation of cell shape | 92/8552 | 154/18723 | 3.00e-04 | 1.81e-03 | 92 |
GO:00226047 | Liver | NAFLD | regulation of cell morphogenesis | 62/1882 | 309/18723 | 8.35e-08 | 7.09e-06 | 62 |
GO:00083606 | Liver | NAFLD | regulation of cell shape | 27/1882 | 154/18723 | 2.92e-03 | 2.65e-02 | 27 |
GO:002260412 | Liver | Cirrhotic | regulation of cell morphogenesis | 127/4634 | 309/18723 | 1.45e-10 | 7.44e-09 | 127 |
GO:000836012 | Liver | Cirrhotic | regulation of cell shape | 69/4634 | 154/18723 | 4.21e-08 | 1.36e-06 | 69 |
GO:002260422 | Liver | HCC | regulation of cell morphogenesis | 188/7958 | 309/18723 | 4.84e-11 | 1.82e-09 | 188 |
GO:000836022 | Liver | HCC | regulation of cell shape | 92/7958 | 154/18723 | 1.15e-05 | 1.31e-04 | 92 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
BRWD1 | SNV | Missense_Mutation | c.4199N>G | p.Ile1400Ser | p.I1400S | Q9NSI6 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AG-3892-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
BRWD1 | SNV | Missense_Mutation | c.6818N>A | p.Ser2273Tyr | p.S2273Y | Q9NSI6 | protein_coding | deleterious_low_confidence(0.01) | possibly_damaging(0.65) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
BRWD1 | SNV | Missense_Mutation | novel | c.6613N>G | p.Thr2205Ala | p.T2205A | Q9NSI6 | protein_coding | tolerated_low_confidence(0.16) | benign(0.001) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
BRWD1 | SNV | Missense_Mutation | rs747796867 | c.5447N>A | p.Thr1816Asn | p.T1816N | Q9NSI6 | protein_coding | deleterious_low_confidence(0) | benign(0.031) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
BRWD1 | SNV | Missense_Mutation | c.2505A>C | p.Glu835Asp | p.E835D | Q9NSI6 | protein_coding | tolerated(0.24) | benign(0.005) | TCGA-AG-A01Y-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR | |
BRWD1 | SNV | Missense_Mutation | rs370655540 | c.4054G>A | p.Asp1352Asn | p.D1352N | Q9NSI6 | protein_coding | tolerated(0.08) | benign(0.029) | TCGA-EI-6882-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
BRWD1 | deletion | Frame_Shift_Del | c.603_604delNN | p.Phe202TyrfsTer5 | p.F202Yfs*5 | Q9NSI6 | protein_coding | TCGA-AA-A01R-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5-fluorouracil | PD | |||
BRWD1 | deletion | Frame_Shift_Del | c.4170delN | p.Ala1391ArgfsTer13 | p.A1391Rfs*13 | Q9NSI6 | protein_coding | TCGA-AD-A5EJ-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
BRWD1 | insertion | Frame_Shift_Ins | novel | c.1666_1667insTGGA | p.Asp556ValfsTer9 | p.D556Vfs*9 | Q9NSI6 | protein_coding | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
BRWD1 | insertion | Frame_Shift_Ins | novel | c.3919dupA | p.Ser1307LysfsTer9 | p.S1307Kfs*9 | Q9NSI6 | protein_coding | TCGA-CM-5861-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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