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Gene: BRE |
Gene summary for BRE |
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Gene information | Species | Human | Gene symbol | BRE | Gene ID | 9577 |
Gene name | BRISC and BRCA1 A complex member 2 | |
Gene Alias | BRCC4 | |
Cytomap | 2p23.2 | |
Gene Type | protein-coding | GO ID | GO:0000075 | UniProtAcc | Q9NXR7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9577 | BRE | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.94e-44 | 7.60e-01 | 0.294 |
9577 | BRE | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 5.11e-13 | 1.29e+00 | 0.3487 |
9577 | BRE | HTA11_99999965104_69814 | Human | Colorectum | MSS | 5.00e-45 | 1.20e+00 | 0.281 |
9577 | BRE | HTA11_99999971662_82457 | Human | Colorectum | MSS | 2.48e-66 | 1.28e+00 | 0.3859 |
9577 | BRE | HTA11_99999973899_84307 | Human | Colorectum | MSS | 3.46e-22 | 6.60e-01 | 0.2585 |
9577 | BRE | HTA11_99999974143_84620 | Human | Colorectum | MSS | 9.08e-52 | 9.19e-01 | 0.3005 |
9577 | BRE | AEH-subject1 | Human | Endometrium | AEH | 1.89e-07 | -1.95e-01 | -0.3059 |
9577 | BRE | AEH-subject2 | Human | Endometrium | AEH | 2.49e-08 | -1.95e-01 | -0.2525 |
9577 | BRE | AEH-subject3 | Human | Endometrium | AEH | 4.07e-08 | -1.95e-01 | -0.2576 |
9577 | BRE | AEH-subject4 | Human | Endometrium | AEH | 6.90e-06 | -1.95e-01 | -0.2657 |
9577 | BRE | AEH-subject5 | Human | Endometrium | AEH | 4.07e-08 | -1.95e-01 | -0.2953 |
9577 | BRE | EEC-subject1 | Human | Endometrium | EEC | 1.85e-09 | -1.95e-01 | -0.2682 |
9577 | BRE | EEC-subject2 | Human | Endometrium | EEC | 8.77e-08 | -1.95e-01 | -0.2607 |
9577 | BRE | EEC-subject3 | Human | Endometrium | EEC | 1.88e-08 | -1.95e-01 | -0.2525 |
9577 | BRE | EEC-subject4 | Human | Endometrium | EEC | 4.01e-09 | -1.95e-01 | -0.2571 |
9577 | BRE | EEC-subject5 | Human | Endometrium | EEC | 8.71e-07 | -1.95e-01 | -0.249 |
9577 | BRE | GSM5276934 | Human | Endometrium | EEC | 3.89e-10 | -1.95e-01 | -0.0913 |
9577 | BRE | GSM5276935 | Human | Endometrium | EEC | 8.49e-10 | -1.95e-01 | -0.123 |
9577 | BRE | GSM5276937 | Human | Endometrium | EEC | 1.10e-07 | -1.95e-01 | -0.0897 |
9577 | BRE | GSM6177620_NYU_UCEC1_lib1_lib1 | Human | Endometrium | EEC | 2.30e-06 | -1.95e-01 | -0.1869 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
BRE | SNV | Missense_Mutation | novel | c.1231N>A | p.Glu411Lys | p.E411K | Q9NXR7 | protein_coding | benign(0.015) | TCGA-HU-8238-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | didox | SD | |
BRE | SNV | Missense_Mutation | novel | c.86N>A | p.Leu29Gln | p.L29Q | Q9NXR7 | protein_coding | deleterious(0.01) | probably_damaging(0.994) | TCGA-RD-A8N1-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | 5-fluorouracil | SD |
BRE | SNV | Missense_Mutation | novel | c.247N>A | p.Asp83Asn | p.D83N | Q9NXR7 | protein_coding | deleterious(0) | probably_damaging(0.988) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response | |
BRE | insertion | Frame_Shift_Ins | novel | c.115_116insGACAGCAT | p.Asp39GlyfsTer5 | p.D39Gfs*5 | Q9NXR7 | protein_coding | TCGA-EL-A3ZG-01 | Thyroid | thyroid carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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