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Gene: BMP7 |
Gene summary for BMP7 |
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Gene information | Species | Human | Gene symbol | BMP7 | Gene ID | 655 |
Gene name | bone morphogenetic protein 7 | |
Gene Alias | OP-1 | |
Cytomap | 20q13.31 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | A8K571 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
655 | BMP7 | HTA11_8622_2000001021 | Human | Colorectum | SER | 4.45e-03 | 1.99e-01 | 0.0528 |
655 | BMP7 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 4.40e-09 | 1.80e-01 | 0.294 |
655 | BMP7 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 4.02e-55 | 1.15e+00 | 0.3859 |
655 | BMP7 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 2.69e-51 | 7.99e-01 | 0.3005 |
655 | BMP7 | A001-C-119 | Human | Colorectum | FAP | 4.39e-03 | 2.33e-01 | -0.1557 |
655 | BMP7 | A015-C-005 | Human | Colorectum | FAP | 5.50e-03 | 1.91e-01 | -0.0336 |
655 | BMP7 | CRC-1-8810 | Human | Colorectum | CRC | 5.87e-11 | 4.35e-01 | 0.6257 |
655 | BMP7 | CRC-3-11773 | Human | Colorectum | CRC | 5.54e-31 | 7.56e-01 | 0.2564 |
655 | BMP7 | LZE4T | Human | Esophagus | ESCC | 4.78e-06 | 1.59e-01 | 0.0811 |
655 | BMP7 | LZE7T | Human | Esophagus | ESCC | 1.80e-04 | 4.93e-01 | 0.0667 |
655 | BMP7 | LZE8T | Human | Esophagus | ESCC | 4.93e-02 | 4.86e-03 | 0.067 |
655 | BMP7 | LZE22D1 | Human | Esophagus | HGIN | 4.82e-03 | 1.34e-01 | 0.0595 |
655 | BMP7 | LZE22T | Human | Esophagus | ESCC | 7.19e-03 | 2.23e-01 | 0.068 |
655 | BMP7 | LZE24T | Human | Esophagus | ESCC | 7.78e-05 | 3.05e-01 | 0.0596 |
655 | BMP7 | LZE21T | Human | Esophagus | ESCC | 1.29e-06 | 2.89e-01 | 0.0655 |
655 | BMP7 | P2T-E | Human | Esophagus | ESCC | 4.50e-38 | 9.78e-01 | 0.1177 |
655 | BMP7 | P4T-E | Human | Esophagus | ESCC | 8.17e-30 | 9.66e-01 | 0.1323 |
655 | BMP7 | P5T-E | Human | Esophagus | ESCC | 8.35e-12 | 3.30e-01 | 0.1327 |
655 | BMP7 | P8T-E | Human | Esophagus | ESCC | 1.34e-11 | 6.83e-03 | 0.0889 |
655 | BMP7 | P9T-E | Human | Esophagus | ESCC | 2.35e-15 | 2.90e-01 | 0.1131 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00487321 | Colorectum | SER | gland development | 112/2897 | 436/18723 | 1.75e-08 | 1.28e-06 | 112 |
GO:00069791 | Colorectum | SER | response to oxidative stress | 114/2897 | 446/18723 | 1.75e-08 | 1.28e-06 | 114 |
GO:00003021 | Colorectum | SER | response to reactive oxygen species | 65/2897 | 222/18723 | 1.21e-07 | 7.29e-06 | 65 |
GO:00106391 | Colorectum | SER | negative regulation of organelle organization | 90/2897 | 348/18723 | 3.14e-07 | 1.69e-05 | 90 |
GO:00621971 | Colorectum | SER | cellular response to chemical stress | 87/2897 | 337/18723 | 5.33e-07 | 2.59e-05 | 87 |
GO:00096361 | Colorectum | SER | response to toxic substance | 71/2897 | 262/18723 | 8.63e-07 | 4.07e-05 | 71 |
GO:00972371 | Colorectum | SER | cellular response to toxic substance | 40/2897 | 124/18723 | 2.28e-06 | 9.43e-05 | 40 |
GO:00987541 | Colorectum | SER | detoxification | 46/2897 | 152/18723 | 3.02e-06 | 1.20e-04 | 46 |
GO:00513481 | Colorectum | SER | negative regulation of transferase activity | 70/2897 | 268/18723 | 4.27e-06 | 1.62e-04 | 70 |
GO:00345041 | Colorectum | SER | protein localization to nucleus | 74/2897 | 290/18723 | 5.74e-06 | 2.05e-04 | 74 |
GO:19907481 | Colorectum | SER | cellular detoxification | 37/2897 | 116/18723 | 7.20e-06 | 2.48e-04 | 37 |
GO:00345991 | Colorectum | SER | cellular response to oxidative stress | 73/2897 | 288/18723 | 8.52e-06 | 2.86e-04 | 73 |
GO:00018901 | Colorectum | SER | placenta development | 43/2897 | 144/18723 | 9.10e-06 | 3.03e-04 | 43 |
GO:00713831 | Colorectum | SER | cellular response to steroid hormone stimulus | 55/2897 | 204/18723 | 1.66e-05 | 5.05e-04 | 55 |
GO:00018921 | Colorectum | SER | embryonic placenta development | 28/2897 | 82/18723 | 2.24e-05 | 6.43e-04 | 28 |
GO:00105631 | Colorectum | SER | negative regulation of phosphorus metabolic process | 101/2897 | 442/18723 | 2.39e-05 | 6.70e-04 | 101 |
GO:00459361 | Colorectum | SER | negative regulation of phosphate metabolic process | 100/2897 | 441/18723 | 3.62e-05 | 9.39e-04 | 100 |
GO:00725931 | Colorectum | SER | reactive oxygen species metabolic process | 61/2897 | 239/18723 | 3.63e-05 | 9.39e-04 | 61 |
GO:00316671 | Colorectum | SER | response to nutrient levels | 106/2897 | 474/18723 | 3.94e-05 | 1.00e-03 | 106 |
GO:00485451 | Colorectum | SER | response to steroid hormone | 80/2897 | 339/18723 | 5.15e-05 | 1.25e-03 | 80 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04350 | Colorectum | SER | TGF-beta signaling pathway | 31/1580 | 108/8465 | 7.00e-03 | 3.77e-02 | 2.74e-02 | 31 |
hsa043501 | Colorectum | SER | TGF-beta signaling pathway | 31/1580 | 108/8465 | 7.00e-03 | 3.77e-02 | 2.74e-02 | 31 |
hsa04390 | Colorectum | MSS | Hippo signaling pathway | 48/1875 | 157/8465 | 8.32e-03 | 3.10e-02 | 1.90e-02 | 48 |
hsa043602 | Colorectum | MSS | Axon guidance | 54/1875 | 182/8465 | 1.03e-02 | 3.69e-02 | 2.26e-02 | 54 |
hsa043901 | Colorectum | MSS | Hippo signaling pathway | 48/1875 | 157/8465 | 8.32e-03 | 3.10e-02 | 1.90e-02 | 48 |
hsa043603 | Colorectum | MSS | Axon guidance | 54/1875 | 182/8465 | 1.03e-02 | 3.69e-02 | 2.26e-02 | 54 |
hsa043604 | Colorectum | FAP | Axon guidance | 47/1404 | 182/8465 | 9.09e-04 | 5.20e-03 | 3.16e-03 | 47 |
hsa043902 | Colorectum | FAP | Hippo signaling pathway | 41/1404 | 157/8465 | 1.49e-03 | 7.91e-03 | 4.81e-03 | 41 |
hsa043605 | Colorectum | FAP | Axon guidance | 47/1404 | 182/8465 | 9.09e-04 | 5.20e-03 | 3.16e-03 | 47 |
hsa043903 | Colorectum | FAP | Hippo signaling pathway | 41/1404 | 157/8465 | 1.49e-03 | 7.91e-03 | 4.81e-03 | 41 |
hsa043606 | Colorectum | CRC | Axon guidance | 43/1091 | 182/8465 | 4.38e-05 | 8.70e-04 | 5.90e-04 | 43 |
hsa043904 | Colorectum | CRC | Hippo signaling pathway | 32/1091 | 157/8465 | 5.17e-03 | 2.72e-02 | 1.84e-02 | 32 |
hsa043607 | Colorectum | CRC | Axon guidance | 43/1091 | 182/8465 | 4.38e-05 | 8.70e-04 | 5.90e-04 | 43 |
hsa043905 | Colorectum | CRC | Hippo signaling pathway | 32/1091 | 157/8465 | 5.17e-03 | 2.72e-02 | 1.84e-02 | 32 |
hsa043507 | Esophagus | ESCC | TGF-beta signaling pathway | 69/4205 | 108/8465 | 1.92e-03 | 5.54e-03 | 2.84e-03 | 69 |
hsa0436016 | Esophagus | ESCC | Axon guidance | 108/4205 | 182/8465 | 5.13e-03 | 1.30e-02 | 6.67e-03 | 108 |
hsa0439018 | Esophagus | ESCC | Hippo signaling pathway | 92/4205 | 157/8465 | 1.46e-02 | 3.31e-02 | 1.69e-02 | 92 |
hsa0435014 | Esophagus | ESCC | TGF-beta signaling pathway | 69/4205 | 108/8465 | 1.92e-03 | 5.54e-03 | 2.84e-03 | 69 |
hsa0436017 | Esophagus | ESCC | Axon guidance | 108/4205 | 182/8465 | 5.13e-03 | 1.30e-02 | 6.67e-03 | 108 |
hsa0439019 | Esophagus | ESCC | Hippo signaling pathway | 92/4205 | 157/8465 | 1.46e-02 | 3.31e-02 | 1.69e-02 | 92 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
BMP7 | ACVR1_ACVR2A | BMP7_ACVR1_ACVR2A | BMP | Cervix | CC |
BMP7 | ACVR1_BMPR2 | BMP7_ACVR1_BMPR2 | BMP | Cervix | CC |
BMP7 | BMPR1A_ACVR2A | BMP7_BMPR1A_ACVR2A | BMP | Cervix | CC |
BMP7 | BMPR1A_BMPR2 | BMP7_BMPR1A_BMPR2 | BMP | Cervix | CC |
BMP7 | BMPR1B_ACVR2A | BMP7_BMPR1B_ACVR2A | BMP | Cervix | CC |
BMP7 | BMPR1B_BMPR2 | BMP7_BMPR1B_BMPR2 | BMP | Cervix | CC |
BMP7 | ACVR1_BMPR2 | BMP7_ACVR1_BMPR2 | BMP | Endometrium | AEH |
BMP7 | BMPR1A_BMPR2 | BMP7_BMPR1A_BMPR2 | BMP | Endometrium | AEH |
BMP7 | BMPR1B_BMPR2 | BMP7_BMPR1B_BMPR2 | BMP | Endometrium | AEH |
BMP7 | ACVR1_BMPR2 | BMP7_ACVR1_BMPR2 | BMP | Esophagus | ESCC |
BMP7 | BMPR1A_ACVR2B | BMP7_BMPR1A_ACVR2B | BMP | Esophagus | ESCC |
BMP7 | ACVR1_BMPR2 | BMP7_ACVR1_BMPR2 | BMP | HNSCC | OSCC |
BMP7 | ACVR1_BMPR2 | BMP7_ACVR1_BMPR2 | BMP | HNSCC | Precancer |
BMP7 | BMPR1A_BMPR2 | BMP7_BMPR1A_BMPR2 | BMP | HNSCC | Precancer |
BMP7 | ACVR1_BMPR2 | BMP7_ACVR1_BMPR2 | BMP | THCA | ADJ |
BMP7 | BMPR1A_ACVR2A | BMP7_BMPR1A_ACVR2A | BMP | THCA | ADJ |
BMP7 | BMPR1A_BMPR2 | BMP7_BMPR1A_BMPR2 | BMP | THCA | ADJ |
BMP7 | ACVR1_BMPR2 | BMP7_ACVR1_BMPR2 | BMP | THCA | PTC |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
BMP7 | SNV | Missense_Mutation | novel | c.1184G>T | p.Cys395Phe | p.C395F | P18075 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-3K-AAZ8-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | III/IV | Targeted Molecular therapy | sorafenib | PD |
BMP7 | SNV | Missense_Mutation | c.334N>T | p.Ser112Cys | p.S112C | P18075 | protein_coding | deleterious(0.01) | benign(0.057) | TCGA-CC-5264-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
BMP7 | SNV | Missense_Mutation | c.334N>T | p.Ser112Cys | p.S112C | P18075 | protein_coding | deleterious(0.01) | benign(0.057) | TCGA-DD-A1EE-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD | |
BMP7 | SNV | Missense_Mutation | novel | c.47N>A | p.Ala16Glu | p.A16E | P18075 | protein_coding | tolerated_low_confidence(0.1) | benign(0.031) | TCGA-K7-A5RG-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
BMP7 | SNV | Missense_Mutation | c.137N>C | p.Leu46Pro | p.L46P | P18075 | protein_coding | deleterious(0) | probably_damaging(0.916) | TCGA-UB-A7MB-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Targeted Molecular therapy | sorafenib | PD | |
BMP7 | SNV | Missense_Mutation | novel | c.584N>G | p.Tyr195Cys | p.Y195C | P18075 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-38-4626-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
BMP7 | SNV | Missense_Mutation | c.754N>A | p.Leu252Met | p.L252M | P18075 | protein_coding | tolerated(0.1) | benign(0.062) | TCGA-49-AARQ-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
BMP7 | SNV | Missense_Mutation | c.865C>G | p.Arg289Gly | p.R289G | P18075 | protein_coding | deleterious(0) | possibly_damaging(0.738) | TCGA-53-7624-01 | Lung | lung adenocarcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | PD | |
BMP7 | SNV | Missense_Mutation | novel | c.350C>A | p.Pro117His | p.P117H | P18075 | protein_coding | deleterious(0.04) | benign(0.052) | TCGA-53-A4EZ-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | CR |
BMP7 | SNV | Missense_Mutation | c.1175N>A | p.Pro392His | p.P392H | P18075 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-55-7994-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
655 | BMP7 | TRANSCRIPTION FACTOR, DRUGGABLE GENOME, GROWTH FACTOR | pegaspargase | PEGASPARGASE | 26590194 | |
655 | BMP7 | TRANSCRIPTION FACTOR, DRUGGABLE GENOME, GROWTH FACTOR | methotrexate | METHOTREXATE | 26590194 | |
655 | BMP7 | TRANSCRIPTION FACTOR, DRUGGABLE GENOME, GROWTH FACTOR | cyclophosphamide | CYCLOPHOSPHAMIDE | 26590194 | |
655 | BMP7 | TRANSCRIPTION FACTOR, DRUGGABLE GENOME, GROWTH FACTOR | thioguanine | THIOGUANINE | 26590194 | |
655 | BMP7 | TRANSCRIPTION FACTOR, DRUGGABLE GENOME, GROWTH FACTOR | prednisone | PREDNISONE | 26590194 | |
655 | BMP7 | TRANSCRIPTION FACTOR, DRUGGABLE GENOME, GROWTH FACTOR | dexamethasone | DEXAMETHASONE | 26590194 | |
655 | BMP7 | TRANSCRIPTION FACTOR, DRUGGABLE GENOME, GROWTH FACTOR | cytarabine | CYTARABINE | 26590194 | |
655 | BMP7 | TRANSCRIPTION FACTOR, DRUGGABLE GENOME, GROWTH FACTOR | vincristine | VINCRISTINE | 26590194 | |
655 | BMP7 | TRANSCRIPTION FACTOR, DRUGGABLE GENOME, GROWTH FACTOR | daunorubicin | DAUNORUBICIN | 26590194 | |
655 | BMP7 | TRANSCRIPTION FACTOR, DRUGGABLE GENOME, GROWTH FACTOR | doxorubicin | DOXORUBICIN | 26590194 |
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