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Gene: ATP13A3 |
Gene summary for ATP13A3 |
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Gene information | Species | Human | Gene symbol | ATP13A3 | Gene ID | 79572 |
Gene name | ATPase 13A3 | |
Gene Alias | AFURS1 | |
Cytomap | 3q29 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q9H7F0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79572 | ATP13A3 | CCI_1 | Human | Cervix | CC | 6.64e-09 | 7.38e-01 | 0.528 |
79572 | ATP13A3 | CCI_2 | Human | Cervix | CC | 2.14e-17 | 1.74e+00 | 0.5249 |
79572 | ATP13A3 | CCI_3 | Human | Cervix | CC | 1.63e-09 | 7.80e-01 | 0.516 |
79572 | ATP13A3 | sample3 | Human | Cervix | CC | 5.68e-03 | 1.79e-01 | 0.1387 |
79572 | ATP13A3 | T1 | Human | Cervix | CC | 2.75e-16 | 5.36e-01 | 0.0918 |
79572 | ATP13A3 | AEH-subject1 | Human | Endometrium | AEH | 2.44e-10 | 3.44e-01 | -0.3059 |
79572 | ATP13A3 | AEH-subject4 | Human | Endometrium | AEH | 2.17e-11 | 5.03e-01 | -0.2657 |
79572 | ATP13A3 | AEH-subject5 | Human | Endometrium | AEH | 1.31e-07 | 3.73e-01 | -0.2953 |
79572 | ATP13A3 | EEC-subject1 | Human | Endometrium | EEC | 7.32e-10 | 4.05e-01 | -0.2682 |
79572 | ATP13A3 | EEC-subject3 | Human | Endometrium | EEC | 1.97e-03 | 3.19e-01 | -0.2525 |
79572 | ATP13A3 | EEC-subject5 | Human | Endometrium | EEC | 1.92e-02 | 2.68e-01 | -0.249 |
79572 | ATP13A3 | GSM5276934 | Human | Endometrium | EEC | 6.20e-17 | 5.25e-01 | -0.0913 |
79572 | ATP13A3 | GSM5276937 | Human | Endometrium | EEC | 6.08e-25 | 6.76e-01 | -0.0897 |
79572 | ATP13A3 | GSM6177620_NYU_UCEC1_lib1_lib1 | Human | Endometrium | EEC | 5.75e-06 | 1.04e-01 | -0.1869 |
79572 | ATP13A3 | GSM6177620_NYU_UCEC1_lib2_lib2 | Human | Endometrium | EEC | 1.92e-06 | 1.03e-01 | -0.1875 |
79572 | ATP13A3 | GSM6177620_NYU_UCEC1_lib3_lib3 | Human | Endometrium | EEC | 6.64e-10 | 6.41e-02 | -0.1883 |
79572 | ATP13A3 | GSM6177621_NYU_UCEC2_lib1_lib1 | Human | Endometrium | EEC | 2.38e-02 | 1.07e-01 | -0.1934 |
79572 | ATP13A3 | GSM6177622_NYU_UCEC3_lib1_lib1 | Human | Endometrium | EEC | 6.45e-06 | 9.82e-03 | -0.1917 |
79572 | ATP13A3 | GSM6177622_NYU_UCEC3_lib2_lib2 | Human | Endometrium | EEC | 6.78e-08 | 1.15e-02 | -0.1916 |
79572 | ATP13A3 | GSM6177623_NYU_UCEC3_Vis | Human | Endometrium | EEC | 2.53e-03 | 2.75e-01 | -0.1269 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00725032 | Oral cavity | EOLP | cellular divalent inorganic cation homeostasis | 75/2218 | 486/18723 | 9.77e-03 | 4.42e-02 | 75 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ATP13A3 | SNV | Missense_Mutation | rs753740880 | c.2786N>A | p.Arg929His | p.R929H | Q9H7F0 | protein_coding | deleterious(0.02) | probably_damaging(1) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ATP13A3 | SNV | Missense_Mutation | c.3661C>A | p.Gln1221Lys | p.Q1221K | Q9H7F0 | protein_coding | deleterious_low_confidence(0.02) | probably_damaging(0.952) | TCGA-AP-A1E0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD | |
ATP13A3 | SNV | Missense_Mutation | novel | c.2893G>A | p.Asp965Asn | p.D965N | Q9H7F0 | protein_coding | tolerated(1) | probably_damaging(0.913) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
ATP13A3 | SNV | Missense_Mutation | novel | c.2690G>A | p.Gly897Asp | p.G897D | Q9H7F0 | protein_coding | deleterious(0) | probably_damaging(0.988) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
ATP13A3 | SNV | Missense_Mutation | c.314N>C | p.Lys105Thr | p.K105T | Q9H7F0 | protein_coding | tolerated(0.52) | benign(0.003) | TCGA-AX-A0J0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ATP13A3 | SNV | Missense_Mutation | rs755718276 | c.1067N>A | p.Arg356Gln | p.R356Q | Q9H7F0 | protein_coding | deleterious(0.03) | possibly_damaging(0.746) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
ATP13A3 | SNV | Missense_Mutation | novel | c.650N>G | p.Ile217Ser | p.I217S | Q9H7F0 | protein_coding | deleterious(0) | possibly_damaging(0.908) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
ATP13A3 | SNV | Missense_Mutation | novel | c.3496C>T | p.Arg1166Trp | p.R1166W | Q9H7F0 | protein_coding | deleterious(0.02) | benign(0) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
ATP13A3 | SNV | Missense_Mutation | rs531855588 | c.3184G>A | p.Glu1062Lys | p.E1062K | Q9H7F0 | protein_coding | tolerated(0.53) | benign(0.003) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD |
ATP13A3 | SNV | Missense_Mutation | c.2386A>G | p.Thr796Ala | p.T796A | Q9H7F0 | protein_coding | tolerated(0.69) | benign(0.001) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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