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Gene: ASTE1 |
Gene summary for ASTE1 |
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Gene information | Species | Human | Gene symbol | ASTE1 | Gene ID | 28990 |
Gene name | asteroid homolog 1 | |
Gene Alias | HT001 | |
Cytomap | 3q22.1 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | D6RG30 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
28990 | ASTE1 | LZE4T | Human | Esophagus | ESCC | 1.20e-04 | 1.54e-01 | 0.0811 |
28990 | ASTE1 | LZE24T | Human | Esophagus | ESCC | 1.28e-07 | 1.90e-01 | 0.0596 |
28990 | ASTE1 | P2T-E | Human | Esophagus | ESCC | 1.61e-32 | 5.06e-01 | 0.1177 |
28990 | ASTE1 | P4T-E | Human | Esophagus | ESCC | 6.14e-11 | 2.39e-01 | 0.1323 |
28990 | ASTE1 | P5T-E | Human | Esophagus | ESCC | 2.02e-06 | 1.54e-01 | 0.1327 |
28990 | ASTE1 | P8T-E | Human | Esophagus | ESCC | 3.89e-12 | 2.17e-01 | 0.0889 |
28990 | ASTE1 | P10T-E | Human | Esophagus | ESCC | 1.53e-19 | 3.12e-01 | 0.116 |
28990 | ASTE1 | P11T-E | Human | Esophagus | ESCC | 1.72e-04 | 1.69e-01 | 0.1426 |
28990 | ASTE1 | P12T-E | Human | Esophagus | ESCC | 1.47e-14 | 2.61e-01 | 0.1122 |
28990 | ASTE1 | P15T-E | Human | Esophagus | ESCC | 5.19e-07 | 1.66e-01 | 0.1149 |
28990 | ASTE1 | P16T-E | Human | Esophagus | ESCC | 6.56e-15 | 2.12e-01 | 0.1153 |
28990 | ASTE1 | P17T-E | Human | Esophagus | ESCC | 1.49e-02 | 1.49e-01 | 0.1278 |
28990 | ASTE1 | P20T-E | Human | Esophagus | ESCC | 4.80e-17 | 3.44e-01 | 0.1124 |
28990 | ASTE1 | P21T-E | Human | Esophagus | ESCC | 1.96e-05 | 1.40e-01 | 0.1617 |
28990 | ASTE1 | P22T-E | Human | Esophagus | ESCC | 4.40e-09 | 1.89e-01 | 0.1236 |
28990 | ASTE1 | P23T-E | Human | Esophagus | ESCC | 2.89e-02 | 1.25e-01 | 0.108 |
28990 | ASTE1 | P24T-E | Human | Esophagus | ESCC | 1.78e-03 | 9.39e-02 | 0.1287 |
28990 | ASTE1 | P26T-E | Human | Esophagus | ESCC | 1.76e-12 | 2.82e-01 | 0.1276 |
28990 | ASTE1 | P27T-E | Human | Esophagus | ESCC | 2.06e-08 | 1.95e-01 | 0.1055 |
28990 | ASTE1 | P28T-E | Human | Esophagus | ESCC | 8.84e-05 | 1.39e-01 | 0.1149 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00903053 | Esophagus | ESCC | nucleic acid phosphodiester bond hydrolysis | 163/8552 | 261/18723 | 3.07e-08 | 5.73e-07 | 163 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ASTE1 | SNV | Missense_Mutation | novel | c.1910N>A | p.Arg637Lys | p.R637K | protein_coding | tolerated(1) | benign(0) | TCGA-CV-7568-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ASTE1 | SNV | Missense_Mutation | novel | c.922G>C | p.Asp308His | p.D308H | protein_coding | tolerated(0.09) | benign(0.104) | TCGA-CX-7086-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
ASTE1 | SNV | Missense_Mutation | novel | c.1507A>T | p.Ser503Cys | p.S503C | protein_coding | deleterious(0.03) | benign(0.007) | TCGA-F7-A50I-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ASTE1 | SNV | Missense_Mutation | novel | c.124A>G | p.Ser42Gly | p.S42G | protein_coding | tolerated(0.05) | benign(0.037) | TCGA-F7-A624-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ASTE1 | SNV | Missense_Mutation | novel | c.290N>C | p.Arg97Thr | p.R97T | protein_coding | deleterious(0.02) | benign(0.412) | TCGA-IQ-A61E-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | CR | |
ASTE1 | insertion | Frame_Shift_Ins | novel | c.581_582insC | p.Ala195CysfsTer7 | p.A195Cfs*7 | protein_coding | TCGA-CV-5435-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | carboplatin | PD | |||
ASTE1 | insertion | Frame_Shift_Ins | novel | c.998_999insCACTGAA | p.Leu333PhefsTer5 | p.L333Ffs*5 | protein_coding | TCGA-H7-8502-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | unknown | SD | |||
ASTE1 | SNV | Missense_Mutation | novel | c.1394N>A | p.Pro465His | p.P465H | protein_coding | deleterious(0) | probably_damaging(0.972) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD | |
ASTE1 | SNV | Missense_Mutation | rs750336679 | c.1577C>T | p.Ala526Val | p.A526V | protein_coding | tolerated(0.24) | benign(0) | TCGA-BR-4361-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
ASTE1 | SNV | Missense_Mutation | rs550861085 | c.718N>T | p.Arg240Cys | p.R240C | protein_coding | tolerated(0.13) | benign(0.001) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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