![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: ARSK |
Gene summary for ARSK |
![]() |
Gene information | Species | Human | Gene symbol | ARSK | Gene ID | 153642 |
Gene name | arylsulfatase family member K | |
Gene Alias | TSULF | |
Cytomap | 5q15 | |
Gene Type | protein-coding | GO ID | GO:0000323 | UniProtAcc | Q6UWY0 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
153642 | ARSK | HCC1_Meng | Human | Liver | HCC | 1.75e-29 | -1.78e-05 | 0.0246 |
153642 | ARSK | HCC1 | Human | Liver | HCC | 1.42e-09 | 2.67e+00 | 0.5336 |
153642 | ARSK | HCC2 | Human | Liver | HCC | 1.03e-16 | 2.34e+00 | 0.5341 |
153642 | ARSK | HCC5 | Human | Liver | HCC | 4.51e-05 | 6.40e-01 | 0.4932 |
153642 | ARSK | S014 | Human | Liver | HCC | 2.71e-03 | 1.84e-01 | 0.2254 |
153642 | ARSK | S015 | Human | Liver | HCC | 1.87e-02 | 1.94e-01 | 0.2375 |
153642 | ARSK | S016 | Human | Liver | HCC | 1.24e-06 | 2.24e-01 | 0.2243 |
Page: 1 |
![]() |
Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ARSK | SNV | Missense_Mutation | novel | c.829N>T | p.Ala277Ser | p.A277S | Q6UWY0 | protein_coding | tolerated(0.06) | possibly_damaging(0.874) | TCGA-CV-A45Z-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
ARSK | SNV | Missense_Mutation | novel | c.1423A>C | p.Lys475Gln | p.K475Q | Q6UWY0 | protein_coding | tolerated(0.29) | benign(0.006) | TCGA-UF-A7JJ-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | CR |
ARSK | insertion | Frame_Shift_Ins | novel | c.803_804insA | p.Glu271ArgfsTer3 | p.E271Rfs*3 | Q6UWY0 | protein_coding | TCGA-F7-A50G-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | ||
ARSK | SNV | Missense_Mutation | rs776266197 | c.197G>A | p.Arg66His | p.R66H | Q6UWY0 | protein_coding | tolerated(0.8) | benign(0.003) | TCGA-BR-A4QL-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | xeloda | CR |
ARSK | SNV | Missense_Mutation | c.1087A>G | p.Thr363Ala | p.T363A | Q6UWY0 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-CG-5721-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
ARSK | SNV | Missense_Mutation | rs770798168 | c.196N>T | p.Arg66Cys | p.R66C | Q6UWY0 | protein_coding | tolerated(0.15) | possibly_damaging(0.806) | TCGA-HU-A4GT-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | copolang | SD |
ARSK | SNV | Missense_Mutation | c.563G>A | p.Arg188Lys | p.R188K | Q6UWY0 | protein_coding | tolerated(0.32) | benign(0.038) | TCGA-BJ-A28Z-01 | Thyroid | thyroid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |