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Gene: ARHGAP21 |
Gene summary for ARHGAP21 |
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Gene information | Species | Human | Gene symbol | ARHGAP21 | Gene ID | 57584 |
Gene name | Rho GTPase activating protein 21 | |
Gene Alias | ARHGAP10 | |
Cytomap | 10p12.1 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q5T5U3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57584 | ARHGAP21 | CCI_1 | Human | Cervix | CC | 6.74e-05 | 1.22e+00 | 0.528 |
57584 | ARHGAP21 | CCI_2 | Human | Cervix | CC | 5.01e-06 | 8.67e-01 | 0.5249 |
57584 | ARHGAP21 | CCI_3 | Human | Cervix | CC | 8.83e-22 | 1.26e+00 | 0.516 |
57584 | ARHGAP21 | Tumor | Human | Cervix | CC | 3.37e-06 | 2.76e-01 | 0.1241 |
57584 | ARHGAP21 | sample1 | Human | Cervix | CC | 4.74e-13 | 6.84e-01 | 0.0959 |
57584 | ARHGAP21 | sample3 | Human | Cervix | CC | 1.45e-16 | 4.31e-01 | 0.1387 |
57584 | ARHGAP21 | T1 | Human | Cervix | CC | 5.11e-24 | 6.87e-01 | 0.0918 |
57584 | ARHGAP21 | T3 | Human | Cervix | CC | 1.64e-19 | 4.16e-01 | 0.1389 |
57584 | ARHGAP21 | HTA11_3410_2000001011 | Human | Colorectum | AD | 3.92e-06 | -4.74e-01 | 0.0155 |
57584 | ARHGAP21 | HTA11_347_2000001011 | Human | Colorectum | AD | 9.86e-05 | 3.81e-01 | -0.1954 |
57584 | ARHGAP21 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.48e-02 | -3.29e-01 | 0.0674 |
57584 | ARHGAP21 | HTA11_7469_2000001011 | Human | Colorectum | AD | 2.86e-02 | 1.29e-01 | -0.0124 |
57584 | ARHGAP21 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 7.56e-03 | -5.76e-01 | 0.2585 |
57584 | ARHGAP21 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 3.73e-25 | -7.00e-01 | 0.3005 |
57584 | ARHGAP21 | A002-C-010 | Human | Colorectum | FAP | 7.40e-03 | -1.21e-01 | 0.242 |
57584 | ARHGAP21 | A001-C-207 | Human | Colorectum | FAP | 2.08e-04 | -2.04e-01 | 0.1278 |
57584 | ARHGAP21 | A015-C-203 | Human | Colorectum | FAP | 3.14e-28 | -2.71e-01 | -0.1294 |
57584 | ARHGAP21 | A015-C-204 | Human | Colorectum | FAP | 6.52e-06 | -1.90e-01 | -0.0228 |
57584 | ARHGAP21 | A014-C-040 | Human | Colorectum | FAP | 2.02e-07 | -4.24e-01 | -0.1184 |
57584 | ARHGAP21 | A002-C-201 | Human | Colorectum | FAP | 1.86e-14 | -2.56e-01 | 0.0324 |
Page: 1 2 3 4 5 6 7 8 9 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00510566 | Cervix | CC | regulation of small GTPase mediated signal transduction | 75/2311 | 302/18723 | 1.54e-09 | 1.74e-07 | 75 |
GO:00512359 | Cervix | CC | maintenance of location | 78/2311 | 327/18723 | 5.18e-09 | 4.92e-07 | 78 |
GO:005165110 | Cervix | CC | maintenance of location in cell | 55/2311 | 214/18723 | 6.63e-08 | 3.85e-06 | 55 |
GO:00516567 | Cervix | CC | establishment of organelle localization | 76/2311 | 390/18723 | 3.17e-05 | 5.21e-04 | 76 |
GO:00307057 | Cervix | CC | cytoskeleton-dependent intracellular transport | 40/2311 | 195/18723 | 7.92e-04 | 6.99e-03 | 40 |
GO:00070304 | Cervix | CC | Golgi organization | 32/2311 | 157/18723 | 2.78e-03 | 1.87e-02 | 32 |
GO:00516572 | Cervix | CC | maintenance of organelle location | 5/2311 | 11/18723 | 6.92e-03 | 3.74e-02 | 5 |
GO:0051656 | Colorectum | AD | establishment of organelle localization | 131/3918 | 390/18723 | 3.00e-09 | 2.06e-07 | 131 |
GO:0051056 | Colorectum | AD | regulation of small GTPase mediated signal transduction | 94/3918 | 302/18723 | 1.81e-05 | 3.76e-04 | 94 |
GO:0030705 | Colorectum | AD | cytoskeleton-dependent intracellular transport | 60/3918 | 195/18723 | 7.56e-04 | 7.59e-03 | 60 |
GO:0051651 | Colorectum | AD | maintenance of location in cell | 61/3918 | 214/18723 | 5.02e-03 | 3.37e-02 | 61 |
GO:0072384 | Colorectum | AD | organelle transport along microtubule | 28/3918 | 85/18723 | 6.55e-03 | 4.07e-02 | 28 |
GO:00516562 | Colorectum | MSS | establishment of organelle localization | 115/3467 | 390/18723 | 7.30e-08 | 3.67e-06 | 115 |
GO:00510561 | Colorectum | MSS | regulation of small GTPase mediated signal transduction | 82/3467 | 302/18723 | 1.31e-04 | 1.99e-03 | 82 |
GO:00516512 | Colorectum | MSS | maintenance of location in cell | 57/3467 | 214/18723 | 2.07e-03 | 1.76e-02 | 57 |
GO:00307052 | Colorectum | MSS | cytoskeleton-dependent intracellular transport | 52/3467 | 195/18723 | 3.07e-03 | 2.34e-02 | 52 |
GO:0051645 | Colorectum | MSS | Golgi localization | 7/3467 | 14/18723 | 7.51e-03 | 4.72e-02 | 7 |
GO:00516563 | Colorectum | FAP | establishment of organelle localization | 97/2622 | 390/18723 | 5.91e-09 | 9.48e-07 | 97 |
GO:00510562 | Colorectum | FAP | regulation of small GTPase mediated signal transduction | 78/2622 | 302/18723 | 3.25e-08 | 2.85e-06 | 78 |
GO:00307053 | Colorectum | FAP | cytoskeleton-dependent intracellular transport | 47/2622 | 195/18723 | 1.06e-04 | 1.76e-03 | 47 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ARHGAP21 | SNV | Missense_Mutation | c.5684A>C | p.Asn1895Thr | p.N1895T | Q5T5U3 | protein_coding | tolerated(0.4) | benign(0) | TCGA-D5-6930-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ARHGAP21 | SNV | Missense_Mutation | novel | c.4414A>G | p.Ile1472Val | p.I1472V | Q5T5U3 | protein_coding | tolerated(0.41) | benign(0) | TCGA-G4-6322-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | oxaliplatin | PD |
ARHGAP21 | SNV | Missense_Mutation | c.1030N>G | p.Ile344Val | p.I344V | Q5T5U3 | protein_coding | tolerated(0.39) | benign(0.012) | TCGA-AG-3885-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | III/IV | Ancillary | zoledronic | SD | |
ARHGAP21 | SNV | Missense_Mutation | c.1648C>G | p.His550Asp | p.H550D | Q5T5U3 | protein_coding | deleterious(0.03) | possibly_damaging(0.624) | TCGA-AG-3893-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | folinic | CR | |
ARHGAP21 | SNV | Missense_Mutation | rs746024517 | c.3127N>A | p.Glu1043Lys | p.E1043K | Q5T5U3 | protein_coding | tolerated(0.05) | probably_damaging(0.999) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ARHGAP21 | SNV | Missense_Mutation | rs755356977 | c.2333N>A | p.Arg778His | p.R778H | Q5T5U3 | protein_coding | tolerated(0.13) | probably_damaging(0.999) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ARHGAP21 | SNV | Missense_Mutation | novel | c.1920N>T | p.Gln640His | p.Q640H | Q5T5U3 | protein_coding | tolerated(0.05) | possibly_damaging(0.834) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ARHGAP21 | SNV | Missense_Mutation | c.1475N>T | p.Arg492Ile | p.R492I | Q5T5U3 | protein_coding | deleterious(0) | possibly_damaging(0.905) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
ARHGAP21 | SNV | Missense_Mutation | c.4289N>T | p.Pro1430Leu | p.P1430L | Q5T5U3 | protein_coding | tolerated(0.31) | probably_damaging(1) | TCGA-AG-A00Y-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
ARHGAP21 | SNV | Missense_Mutation | rs151326840 | c.5509C>T | p.Arg1837Trp | p.R1837W | Q5T5U3 | protein_coding | deleterious(0.03) | probably_damaging(1) | TCGA-DC-6157-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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