![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: ALMS1 |
Gene summary for ALMS1 |
![]() |
Gene information | Species | Human | Gene symbol | ALMS1 | Gene ID | 7840 |
Gene name | ALMS1 centrosome and basal body associated protein | |
Gene Alias | ALSS | |
Cytomap | 2p13.1 | |
Gene Type | protein-coding | GO ID | GO:0000226 | UniProtAcc | Q8TCU4 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7840 | ALMS1 | LZE2T | Human | Esophagus | ESCC | 1.52e-08 | 5.99e-01 | 0.082 |
7840 | ALMS1 | LZE4T | Human | Esophagus | ESCC | 2.18e-06 | 1.94e-01 | 0.0811 |
7840 | ALMS1 | LZE7T | Human | Esophagus | ESCC | 2.07e-09 | 3.91e-01 | 0.0667 |
7840 | ALMS1 | LZE20T | Human | Esophagus | ESCC | 1.26e-02 | 1.11e-01 | 0.0662 |
7840 | ALMS1 | LZE24T | Human | Esophagus | ESCC | 2.66e-16 | 3.46e-01 | 0.0596 |
7840 | ALMS1 | LZE21T | Human | Esophagus | ESCC | 8.02e-04 | 2.45e-01 | 0.0655 |
7840 | ALMS1 | LZE6T | Human | Esophagus | ESCC | 9.61e-05 | 1.96e-01 | 0.0845 |
7840 | ALMS1 | P1T-E | Human | Esophagus | ESCC | 2.44e-06 | 2.69e-01 | 0.0875 |
7840 | ALMS1 | P2T-E | Human | Esophagus | ESCC | 1.15e-19 | 3.87e-01 | 0.1177 |
7840 | ALMS1 | P4T-E | Human | Esophagus | ESCC | 4.13e-17 | 3.43e-01 | 0.1323 |
7840 | ALMS1 | P5T-E | Human | Esophagus | ESCC | 8.46e-06 | 1.22e-01 | 0.1327 |
7840 | ALMS1 | P8T-E | Human | Esophagus | ESCC | 7.53e-09 | 1.66e-01 | 0.0889 |
7840 | ALMS1 | P10T-E | Human | Esophagus | ESCC | 4.34e-12 | 2.25e-01 | 0.116 |
7840 | ALMS1 | P11T-E | Human | Esophagus | ESCC | 6.74e-09 | 2.86e-01 | 0.1426 |
7840 | ALMS1 | P12T-E | Human | Esophagus | ESCC | 1.07e-12 | 3.25e-01 | 0.1122 |
7840 | ALMS1 | P15T-E | Human | Esophagus | ESCC | 3.34e-06 | 1.72e-01 | 0.1149 |
7840 | ALMS1 | P16T-E | Human | Esophagus | ESCC | 8.19e-10 | 2.12e-01 | 0.1153 |
7840 | ALMS1 | P17T-E | Human | Esophagus | ESCC | 2.68e-03 | 1.82e-01 | 0.1278 |
7840 | ALMS1 | P20T-E | Human | Esophagus | ESCC | 3.32e-24 | 4.80e-01 | 0.1124 |
7840 | ALMS1 | P21T-E | Human | Esophagus | ESCC | 7.33e-10 | 2.22e-01 | 0.1617 |
Page: 1 2 3 4 |
![]() |
Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001619715 | Esophagus | ESCC | endosomal transport | 168/8552 | 230/18723 | 2.28e-17 | 1.93e-15 | 168 |
GO:1902903111 | Esophagus | ESCC | regulation of supramolecular fiber organization | 237/8552 | 383/18723 | 9.06e-11 | 2.75e-09 | 237 |
GO:000701527 | Esophagus | ESCC | actin filament organization | 259/8552 | 442/18723 | 2.37e-08 | 4.50e-07 | 259 |
GO:0032970111 | Esophagus | ESCC | regulation of actin filament-based process | 231/8552 | 397/18723 | 2.91e-07 | 4.20e-06 | 231 |
GO:0032956111 | Esophagus | ESCC | regulation of actin cytoskeleton organization | 210/8552 | 358/18723 | 4.40e-07 | 6.00e-06 | 210 |
GO:011005327 | Esophagus | ESCC | regulation of actin filament organization | 166/8552 | 278/18723 | 1.54e-06 | 1.85e-05 | 166 |
GO:190211514 | Esophagus | ESCC | regulation of organelle assembly | 116/8552 | 186/18723 | 3.15e-06 | 3.53e-05 | 116 |
GO:005101727 | Esophagus | ESCC | actin filament bundle assembly | 100/8552 | 157/18723 | 3.87e-06 | 4.17e-05 | 100 |
GO:00070982 | Esophagus | ESCC | centrosome cycle | 85/8552 | 130/18723 | 4.41e-06 | 4.69e-05 | 85 |
GO:00310233 | Esophagus | ESCC | microtubule organizing center organization | 92/8552 | 143/18723 | 5.04e-06 | 5.31e-05 | 92 |
GO:006157227 | Esophagus | ESCC | actin filament bundle organization | 101/8552 | 161/18723 | 9.22e-06 | 8.82e-05 | 101 |
GO:003003820 | Esophagus | ESCC | contractile actin filament bundle assembly | 67/8552 | 106/18723 | 2.03e-04 | 1.28e-03 | 67 |
GO:004314920 | Esophagus | ESCC | stress fiber assembly | 67/8552 | 106/18723 | 2.03e-04 | 1.28e-03 | 67 |
GO:00328864 | Esophagus | ESCC | regulation of microtubule-based process | 134/8552 | 240/18723 | 9.44e-04 | 4.80e-03 | 134 |
GO:003223120 | Esophagus | ESCC | regulation of actin filament bundle assembly | 64/8552 | 105/18723 | 1.15e-03 | 5.70e-03 | 64 |
GO:005149225 | Esophagus | ESCC | regulation of stress fiber assembly | 56/8552 | 91/18723 | 1.66e-03 | 7.68e-03 | 56 |
GO:003103219 | Esophagus | ESCC | actomyosin structure organization | 108/8552 | 196/18723 | 4.86e-03 | 1.88e-02 | 108 |
GO:011002025 | Esophagus | ESCC | regulation of actomyosin structure organization | 59/8552 | 100/18723 | 4.98e-03 | 1.91e-02 | 59 |
GO:01201624 | Esophagus | ESCC | positive regulation of cold-induced thermogenesis | 57/8552 | 97/18723 | 6.43e-03 | 2.35e-02 | 57 |
GO:01061066 | Esophagus | ESCC | cold-induced thermogenesis | 80/8552 | 144/18723 | 1.07e-02 | 3.65e-02 | 80 |
Page: 1 2 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ALMS1 | SNV | Missense_Mutation | novel | c.9368T>C | p.Leu3123Pro | p.L3123P | protein_coding | tolerated(0.43) | benign(0.311) | TCGA-ZJ-AB0I-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
ALMS1 | SNV | Missense_Mutation | novel | c.5490T>G | p.Ile1830Met | p.I1830M | protein_coding | deleterious(0) | benign(0.089) | TCGA-A6-6141-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | 5-fu | SD | |
ALMS1 | SNV | Missense_Mutation | novel | c.985N>A | p.Glu329Lys | p.E329K | protein_coding | deleterious(0) | possibly_damaging(0.832) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ALMS1 | SNV | Missense_Mutation | novel | c.5554N>T | p.Pro1852Ser | p.P1852S | protein_coding | tolerated(1) | benign(0.003) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ALMS1 | SNV | Missense_Mutation | rs541576664 | c.12037N>A | p.Gly4013Ser | p.G4013S | protein_coding | tolerated(1) | benign(0.022) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ALMS1 | SNV | Missense_Mutation | rs563989825 | c.1052G>A | p.Arg351Gln | p.R351Q | protein_coding | tolerated(1) | benign(0) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ALMS1 | SNV | Missense_Mutation | novel | c.3250N>A | p.Asp1084Asn | p.D1084N | protein_coding | tolerated(0.08) | possibly_damaging(0.908) | TCGA-AA-3697-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ALMS1 | SNV | Missense_Mutation | rs376632767 | c.974N>T | p.Ser325Leu | p.S325L | protein_coding | tolerated(0.13) | benign(0.012) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
ALMS1 | SNV | Missense_Mutation | novel | c.12114G>T | p.Gln4038His | p.Q4038H | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-3845-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
ALMS1 | SNV | Missense_Mutation | novel | c.3029G>T | p.Ser1010Ile | p.S1010I | protein_coding | tolerated(0.25) | benign(0.048) | TCGA-AA-3949-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |