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Gene: AHCYL2 |
Gene summary for AHCYL2 |
Gene summary. |
Gene information | Species | Human | Gene symbol | AHCYL2 | Gene ID | 23382 |
Gene name | adenosylhomocysteinase like 2 | |
Gene Alias | ADOHCYASE3 | |
Cytomap | 7q32.1 | |
Gene Type | protein-coding | GO ID | GO:0006730 | UniProtAcc | Q96HN2 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23382 | AHCYL2 | CCI_2 | Human | Cervix | CC | 1.49e-08 | 1.12e+00 | 0.5249 |
23382 | AHCYL2 | HTA11_3410_2000001011 | Human | Colorectum | AD | 4.94e-24 | -6.82e-01 | 0.0155 |
23382 | AHCYL2 | HTA11_2951_2000001011 | Human | Colorectum | AD | 9.12e-03 | -7.61e-01 | 0.0216 |
23382 | AHCYL2 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.78e-28 | 1.02e+00 | -0.1954 |
23382 | AHCYL2 | HTA11_411_2000001011 | Human | Colorectum | SER | 2.80e-03 | 6.77e-01 | -0.2602 |
23382 | AHCYL2 | HTA11_866_3004761011 | Human | Colorectum | AD | 2.42e-10 | -6.01e-01 | 0.096 |
23382 | AHCYL2 | HTA11_8622_2000001021 | Human | Colorectum | SER | 1.47e-02 | -5.87e-01 | 0.0528 |
23382 | AHCYL2 | HTA11_10711_2000001011 | Human | Colorectum | AD | 3.24e-02 | -4.87e-01 | 0.0338 |
23382 | AHCYL2 | HTA11_7696_3000711011 | Human | Colorectum | AD | 3.33e-06 | -4.29e-01 | 0.0674 |
23382 | AHCYL2 | HTA11_6818_2000001021 | Human | Colorectum | AD | 7.37e-03 | -5.30e-01 | 0.0588 |
23382 | AHCYL2 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 5.38e-22 | -6.12e-01 | 0.294 |
23382 | AHCYL2 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 3.18e-05 | -4.80e-01 | 0.3859 |
23382 | AHCYL2 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 8.32e-03 | -5.90e-01 | 0.2585 |
23382 | AHCYL2 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.29e-20 | -6.54e-01 | 0.3005 |
23382 | AHCYL2 | F007 | Human | Colorectum | FAP | 5.97e-04 | -4.18e-01 | 0.1176 |
23382 | AHCYL2 | A002-C-010 | Human | Colorectum | FAP | 1.02e-02 | -2.20e-01 | 0.242 |
23382 | AHCYL2 | A001-C-207 | Human | Colorectum | FAP | 1.13e-09 | -5.07e-01 | 0.1278 |
23382 | AHCYL2 | A015-C-203 | Human | Colorectum | FAP | 2.86e-40 | -7.15e-01 | -0.1294 |
23382 | AHCYL2 | A015-C-204 | Human | Colorectum | FAP | 1.96e-12 | -5.71e-01 | -0.0228 |
23382 | AHCYL2 | A014-C-040 | Human | Colorectum | FAP | 7.78e-08 | -5.71e-01 | -0.1184 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006790 | Colorectum | AD | sulfur compound metabolic process | 101/3918 | 339/18723 | 6.46e-05 | 1.07e-03 | 101 |
GO:0006730 | Colorectum | AD | one-carbon metabolic process | 18/3918 | 40/18723 | 5.36e-04 | 5.74e-03 | 18 |
GO:00067301 | Colorectum | SER | one-carbon metabolic process | 15/2897 | 40/18723 | 5.71e-04 | 7.86e-03 | 15 |
GO:00067901 | Colorectum | SER | sulfur compound metabolic process | 73/2897 | 339/18723 | 1.75e-03 | 1.81e-02 | 73 |
GO:00067902 | Colorectum | MSS | sulfur compound metabolic process | 85/3467 | 339/18723 | 1.52e-03 | 1.39e-02 | 85 |
GO:00067302 | Colorectum | MSS | one-carbon metabolic process | 15/3467 | 40/18723 | 3.72e-03 | 2.73e-02 | 15 |
GO:00067304 | Skin | cSCC | one-carbon metabolic process | 18/4864 | 40/18723 | 7.10e-03 | 3.40e-02 | 18 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa002704 | Endometrium | EEC | Cysteine and methionine metabolism | 15/1237 | 52/8465 | 6.02e-03 | 3.12e-02 | 2.33e-02 | 15 |
hsa0027011 | Endometrium | EEC | Cysteine and methionine metabolism | 15/1237 | 52/8465 | 6.02e-03 | 3.12e-02 | 2.33e-02 | 15 |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
AHCYL2 | SNV | Missense_Mutation | novel | c.1108A>T | p.Asn370Tyr | p.N370Y | Q96HN2 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-BA-4076-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | PD |
AHCYL2 | SNV | Missense_Mutation | rs773323582 | c.1414A>G | p.Ser472Gly | p.S472G | Q96HN2 | protein_coding | tolerated(1) | benign(0) | TCGA-CN-5355-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
AHCYL2 | SNV | Missense_Mutation | rs746525069 | c.512N>T | p.Ser171Leu | p.S171L | Q96HN2 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.996) | TCGA-CR-7368-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unspecific | Complete Response | |
AHCYL2 | SNV | Missense_Mutation | novel | c.932N>C | p.Gly311Ala | p.G311A | Q96HN2 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-CV-7418-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
AHCYL2 | SNV | Missense_Mutation | novel | c.1675N>G | p.Lys559Glu | p.K559E | Q96HN2 | protein_coding | tolerated(0.26) | possibly_damaging(0.754) | TCGA-F7-A624-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
AHCYL2 | SNV | Missense_Mutation | novel | c.1264G>A | p.Glu422Lys | p.E422K | Q96HN2 | protein_coding | deleterious(0.01) | probably_damaging(0.988) | TCGA-T2-A6WX-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | PD |
AHCYL2 | SNV | Missense_Mutation | c.1442N>A | p.Ser481Tyr | p.S481Y | Q96HN2 | protein_coding | tolerated(0.55) | benign(0.162) | TCGA-G9-7523-01 | Prostate | prostate adenocarcinoma | Male | <65 | 10 | Unknown | Unknown | SD | |
AHCYL2 | SNV | Missense_Mutation | rs766038729 | c.1565G>A | p.Arg522His | p.R522H | Q96HN2 | protein_coding | deleterious(0.03) | benign(0.125) | TCGA-KK-A59V-01 | Prostate | prostate adenocarcinoma | Male | <65 | 9 | Unknown | Unknown | SD |
AHCYL2 | SNV | Missense_Mutation | c.372N>C | p.Gln124His | p.Q124H | Q96HN2 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.736) | TCGA-BR-4201-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | SD | |
AHCYL2 | SNV | Missense_Mutation | c.1808N>T | p.Pro603Leu | p.P603L | Q96HN2 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-BR-4369-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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