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Gene: ADH1C |
Gene summary for ADH1C |
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Gene information | Species | Human | Gene symbol | ADH1C | Gene ID | 126 |
Gene name | alcohol dehydrogenase 1C (class I), gamma polypeptide | |
Gene Alias | ADH3 | |
Cytomap | 4q23 | |
Gene Type | protein-coding | GO ID | GO:0001523 | UniProtAcc | P00326 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
126 | ADH1C | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.98e-34 | 7.35e-01 | 0.0155 |
126 | ADH1C | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.96e-22 | 1.02e+00 | -0.1808 |
126 | ADH1C | HTA11_2951_2000001011 | Human | Colorectum | AD | 1.37e-13 | 8.34e-01 | 0.0216 |
126 | ADH1C | HTA11_1938_2000001011 | Human | Colorectum | AD | 5.71e-13 | 1.01e+00 | -0.0811 |
126 | ADH1C | HTA11_78_2000001011 | Human | Colorectum | AD | 3.29e-37 | 2.10e+00 | -0.1088 |
126 | ADH1C | HTA11_347_2000001011 | Human | Colorectum | AD | 3.28e-94 | 2.38e+00 | -0.1954 |
126 | ADH1C | HTA11_411_2000001011 | Human | Colorectum | SER | 2.24e-10 | 1.11e+00 | -0.2602 |
126 | ADH1C | HTA11_3361_2000001011 | Human | Colorectum | AD | 3.18e-24 | 8.92e-01 | -0.1207 |
126 | ADH1C | HTA11_83_2000001011 | Human | Colorectum | SER | 3.39e-47 | 2.22e+00 | -0.1526 |
126 | ADH1C | HTA11_696_2000001011 | Human | Colorectum | AD | 9.32e-35 | 9.98e-01 | -0.1464 |
126 | ADH1C | HTA11_866_2000001011 | Human | Colorectum | AD | 4.66e-31 | 8.33e-01 | -0.1001 |
126 | ADH1C | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.80e-51 | 1.94e+00 | -0.059 |
126 | ADH1C | HTA11_2992_2000001011 | Human | Colorectum | SER | 5.35e-10 | 8.78e-01 | -0.1706 |
126 | ADH1C | HTA11_5212_2000001011 | Human | Colorectum | AD | 7.74e-19 | 1.04e+00 | -0.2061 |
126 | ADH1C | HTA11_5216_2000001011 | Human | Colorectum | SER | 9.51e-21 | 1.59e+00 | -0.1462 |
126 | ADH1C | HTA11_546_2000001011 | Human | Colorectum | AD | 7.27e-32 | 1.56e+00 | -0.0842 |
126 | ADH1C | HTA11_9341_2000001011 | Human | Colorectum | SER | 1.01e-19 | 1.31e+00 | -0.00410000000000005 |
126 | ADH1C | HTA11_7862_2000001011 | Human | Colorectum | AD | 3.52e-54 | 2.25e+00 | -0.0179 |
126 | ADH1C | HTA11_866_3004761011 | Human | Colorectum | AD | 6.68e-29 | 8.14e-01 | 0.096 |
126 | ADH1C | HTA11_4255_2000001011 | Human | Colorectum | SER | 9.39e-15 | 1.26e+00 | 0.0446 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006091 | Colorectum | AD | generation of precursor metabolites and energy | 209/3918 | 490/18723 | 3.17e-28 | 6.61e-25 | 209 |
GO:0006066 | Colorectum | AD | alcohol metabolic process | 106/3918 | 353/18723 | 3.02e-05 | 5.57e-04 | 106 |
GO:0034308 | Colorectum | AD | primary alcohol metabolic process | 35/3918 | 102/18723 | 1.16e-03 | 1.05e-02 | 35 |
GO:0006067 | Colorectum | AD | ethanol metabolic process | 11/3918 | 21/18723 | 1.43e-03 | 1.22e-02 | 11 |
GO:00060911 | Colorectum | SER | generation of precursor metabolites and energy | 168/2897 | 490/18723 | 1.39e-25 | 1.70e-22 | 168 |
GO:00060661 | Colorectum | SER | alcohol metabolic process | 79/2897 | 353/18723 | 3.50e-04 | 5.50e-03 | 79 |
GO:00343081 | Colorectum | SER | primary alcohol metabolic process | 26/2897 | 102/18723 | 5.87e-03 | 4.29e-02 | 26 |
GO:00060912 | Colorectum | MSS | generation of precursor metabolites and energy | 186/3467 | 490/18723 | 1.14e-24 | 2.15e-21 | 186 |
GO:00060662 | Colorectum | MSS | alcohol metabolic process | 92/3467 | 353/18723 | 2.57e-04 | 3.46e-03 | 92 |
GO:000609120 | Esophagus | HGIN | generation of precursor metabolites and energy | 145/2587 | 490/18723 | 3.41e-20 | 2.04e-17 | 145 |
GO:0006091110 | Esophagus | ESCC | generation of precursor metabolites and energy | 331/8552 | 490/18723 | 3.86e-23 | 8.45e-21 | 331 |
GO:00060668 | Esophagus | ESCC | alcohol metabolic process | 202/8552 | 353/18723 | 7.32e-06 | 7.26e-05 | 202 |
GO:000609118 | Oral cavity | OSCC | generation of precursor metabolites and energy | 286/7305 | 490/18723 | 1.45e-18 | 1.71e-16 | 286 |
GO:00060667 | Oral cavity | OSCC | alcohol metabolic process | 179/7305 | 353/18723 | 4.54e-06 | 5.21e-05 | 179 |
GO:00067203 | Oral cavity | OSCC | isoprenoid metabolic process | 59/7305 | 116/18723 | 6.18e-03 | 2.33e-02 | 59 |
GO:00060916 | Stomach | GC | generation of precursor metabolites and energy | 88/1159 | 490/18723 | 6.82e-20 | 9.27e-17 | 88 |
GO:0120254 | Stomach | GC | olefinic compound metabolic process | 25/1159 | 153/18723 | 7.68e-06 | 2.77e-04 | 25 |
GO:00343084 | Stomach | GC | primary alcohol metabolic process | 19/1159 | 102/18723 | 1.40e-05 | 4.54e-04 | 19 |
GO:00060665 | Stomach | GC | alcohol metabolic process | 41/1159 | 353/18723 | 7.85e-05 | 1.68e-03 | 41 |
GO:0042445 | Stomach | GC | hormone metabolic process | 29/1159 | 218/18723 | 8.22e-05 | 1.75e-03 | 29 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa00620 | Colorectum | AD | Pyruvate metabolism | 28/2092 | 47/8465 | 3.71e-07 | 5.41e-06 | 3.45e-06 | 28 |
hsa00010 | Colorectum | AD | Glycolysis / Gluconeogenesis | 34/2092 | 67/8465 | 3.63e-06 | 4.34e-05 | 2.77e-05 | 34 |
hsa00071 | Colorectum | AD | Fatty acid degradation | 20/2092 | 43/8465 | 1.50e-03 | 8.69e-03 | 5.54e-03 | 20 |
hsa006201 | Colorectum | AD | Pyruvate metabolism | 28/2092 | 47/8465 | 3.71e-07 | 5.41e-06 | 3.45e-06 | 28 |
hsa000101 | Colorectum | AD | Glycolysis / Gluconeogenesis | 34/2092 | 67/8465 | 3.63e-06 | 4.34e-05 | 2.77e-05 | 34 |
hsa000711 | Colorectum | AD | Fatty acid degradation | 20/2092 | 43/8465 | 1.50e-03 | 8.69e-03 | 5.54e-03 | 20 |
hsa006202 | Colorectum | SER | Pyruvate metabolism | 22/1580 | 47/8465 | 9.62e-06 | 1.33e-04 | 9.67e-05 | 22 |
hsa000102 | Colorectum | SER | Glycolysis / Gluconeogenesis | 24/1580 | 67/8465 | 6.62e-04 | 5.36e-03 | 3.89e-03 | 24 |
hsa000712 | Colorectum | SER | Fatty acid degradation | 15/1580 | 43/8465 | 8.60e-03 | 4.26e-02 | 3.09e-02 | 15 |
hsa006203 | Colorectum | SER | Pyruvate metabolism | 22/1580 | 47/8465 | 9.62e-06 | 1.33e-04 | 9.67e-05 | 22 |
hsa000103 | Colorectum | SER | Glycolysis / Gluconeogenesis | 24/1580 | 67/8465 | 6.62e-04 | 5.36e-03 | 3.89e-03 | 24 |
hsa000713 | Colorectum | SER | Fatty acid degradation | 15/1580 | 43/8465 | 8.60e-03 | 4.26e-02 | 3.09e-02 | 15 |
hsa006204 | Colorectum | MSS | Pyruvate metabolism | 24/1875 | 47/8465 | 1.25e-05 | 1.35e-04 | 8.27e-05 | 24 |
hsa000104 | Colorectum | MSS | Glycolysis / Gluconeogenesis | 28/1875 | 67/8465 | 2.36e-04 | 1.81e-03 | 1.11e-03 | 28 |
hsa000714 | Colorectum | MSS | Fatty acid degradation | 17/1875 | 43/8465 | 7.50e-03 | 2.86e-02 | 1.75e-02 | 17 |
hsa006205 | Colorectum | MSS | Pyruvate metabolism | 24/1875 | 47/8465 | 1.25e-05 | 1.35e-04 | 8.27e-05 | 24 |
hsa000105 | Colorectum | MSS | Glycolysis / Gluconeogenesis | 28/1875 | 67/8465 | 2.36e-04 | 1.81e-03 | 1.11e-03 | 28 |
hsa000715 | Colorectum | MSS | Fatty acid degradation | 17/1875 | 43/8465 | 7.50e-03 | 2.86e-02 | 1.75e-02 | 17 |
hsa0062010 | Esophagus | HGIN | Pyruvate metabolism | 16/1383 | 47/8465 | 2.27e-03 | 1.95e-02 | 1.55e-02 | 16 |
hsa0062013 | Esophagus | HGIN | Pyruvate metabolism | 16/1383 | 47/8465 | 2.27e-03 | 1.95e-02 | 1.55e-02 | 16 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ADH1C | SNV | Missense_Mutation | rs755222271 | c.629N>C | p.Met210Thr | p.M210T | P00326 | protein_coding | deleterious(0.01) | possibly_damaging(0.879) | TCGA-91-6848-01 | Lung | lung adenocarcinoma | Male | <65 | III/IV | Chemotherapy | cisplatin | CR |
ADH1C | SNV | Missense_Mutation | novel | c.560N>C | p.Val187Ala | p.V187A | P00326 | protein_coding | deleterious(0.04) | benign(0.09) | TCGA-22-1000-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
ADH1C | SNV | Missense_Mutation | novel | c.1012G>A | p.Ala338Thr | p.A338T | P00326 | protein_coding | tolerated(0.34) | benign(0.275) | TCGA-56-8305-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ADH1C | SNV | Missense_Mutation | novel | c.187N>T | p.Pro63Ser | p.P63S | P00326 | protein_coding | deleterious(0.04) | possibly_damaging(0.841) | TCGA-66-2773-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ADH1C | SNV | Missense_Mutation | novel | c.962G>A | p.Gly321Glu | p.G321E | P00326 | protein_coding | deleterious(0.03) | probably_damaging(0.977) | TCGA-CR-6472-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | paclitaxel | SD |
ADH1C | SNV | Missense_Mutation | novel | c.223N>A | p.Glu75Lys | p.E75K | P00326 | protein_coding | deleterious(0.02) | possibly_damaging(0.634) | TCGA-CV-6950-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
ADH1C | SNV | Missense_Mutation | rs78241133 | c.430N>A | p.Val144Ile | p.V144I | P00326 | protein_coding | tolerated(0.12) | benign(0) | TCGA-D6-A6EQ-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ADH1C | SNV | Missense_Mutation | novel | c.14N>A | p.Gly5Glu | p.G5E | P00326 | protein_coding | deleterious(0.02) | probably_damaging(0.977) | TCGA-G9-6343-01 | Prostate | prostate adenocarcinoma | Male | <65 | 7 | Unknown | Unknown | SD |
ADH1C | SNV | Missense_Mutation | rs370818269 | c.1114N>A | p.Val372Ile | p.V372I | P00326 | protein_coding | tolerated(0.32) | benign(0.003) | TCGA-BR-8487-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ADH1C | SNV | Missense_Mutation | novel | c.547N>A | p.Ser183Thr | p.S183T | P00326 | protein_coding | deleterious(0.02) | benign(0.036) | TCGA-BR-8487-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
126 | ADH1C | ENZYME, DRUGGABLE GENOME | FOMEPIZOLE | FOMEPIZOLE | ||
126 | ADH1C | ENZYME, DRUGGABLE GENOME | cyclophosphamide | CYCLOPHOSPHAMIDE | 24533712 | |
126 | ADH1C | ENZYME, DRUGGABLE GENOME | inhibitor | CHEMBL1308 | FOMEPIZOLE | |
126 | ADH1C | ENZYME, DRUGGABLE GENOME | cisplatin | CISPLATIN | 24533712 | |
126 | ADH1C | ENZYME, DRUGGABLE GENOME | FOMEPIZOLE | FOMEPIZOLE | ||
126 | ADH1C | ENZYME, DRUGGABLE GENOME | RETINOIC ACID | 11959987 | ||
126 | ADH1C | ENZYME, DRUGGABLE GENOME | abacavir | ABACAVIR | 24625462 | |
126 | ADH1C | ENZYME, DRUGGABLE GENOME | ethanol | ALCOHOL | 14693654,32451486 |
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