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Gene: ADAM23 |
Gene summary for ADAM23 |
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Gene information | Species | Human | Gene symbol | ADAM23 | Gene ID | 8745 |
Gene name | ADAM metallopeptidase domain 23 | |
Gene Alias | MDC-3 | |
Cytomap | 2q33.3 | |
Gene Type | protein-coding | GO ID | GO:0006508 | UniProtAcc | A0A024R3W8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8745 | ADAM23 | LZE4T | Human | Esophagus | ESCC | 5.19e-16 | 4.61e-01 | 0.0811 |
8745 | ADAM23 | LZE7T | Human | Esophagus | ESCC | 2.41e-03 | 2.71e-01 | 0.0667 |
8745 | ADAM23 | LZE21T | Human | Esophagus | ESCC | 1.12e-03 | 3.31e-01 | 0.0655 |
8745 | ADAM23 | P2T-E | Human | Esophagus | ESCC | 1.41e-13 | 3.25e-01 | 0.1177 |
8745 | ADAM23 | P4T-E | Human | Esophagus | ESCC | 3.03e-23 | 6.55e-01 | 0.1323 |
8745 | ADAM23 | P9T-E | Human | Esophagus | ESCC | 1.64e-08 | 2.71e-01 | 0.1131 |
8745 | ADAM23 | P11T-E | Human | Esophagus | ESCC | 1.08e-04 | 2.53e-01 | 0.1426 |
8745 | ADAM23 | P12T-E | Human | Esophagus | ESCC | 1.11e-04 | 2.00e-01 | 0.1122 |
8745 | ADAM23 | P15T-E | Human | Esophagus | ESCC | 1.63e-25 | 7.32e-01 | 0.1149 |
8745 | ADAM23 | P22T-E | Human | Esophagus | ESCC | 4.44e-15 | 2.78e-01 | 0.1236 |
8745 | ADAM23 | P26T-E | Human | Esophagus | ESCC | 1.21e-15 | 4.15e-01 | 0.1276 |
8745 | ADAM23 | P27T-E | Human | Esophagus | ESCC | 1.49e-07 | 1.97e-01 | 0.1055 |
8745 | ADAM23 | P30T-E | Human | Esophagus | ESCC | 4.22e-34 | 1.11e+00 | 0.137 |
8745 | ADAM23 | P31T-E | Human | Esophagus | ESCC | 1.25e-02 | 8.61e-02 | 0.1251 |
8745 | ADAM23 | P32T-E | Human | Esophagus | ESCC | 1.18e-10 | 2.80e-01 | 0.1666 |
8745 | ADAM23 | P37T-E | Human | Esophagus | ESCC | 3.28e-02 | 1.36e-01 | 0.1371 |
8745 | ADAM23 | P39T-E | Human | Esophagus | ESCC | 4.74e-07 | 1.28e-01 | 0.0894 |
8745 | ADAM23 | P40T-E | Human | Esophagus | ESCC | 7.95e-18 | 6.10e-01 | 0.109 |
8745 | ADAM23 | P42T-E | Human | Esophagus | ESCC | 1.24e-03 | 3.07e-01 | 0.1175 |
8745 | ADAM23 | P48T-E | Human | Esophagus | ESCC | 1.42e-17 | 6.42e-01 | 0.0959 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:199082316 | Esophagus | ESCC | response to leukemia inhibitory factor | 60/8552 | 95/18723 | 4.41e-04 | 2.48e-03 | 60 |
GO:199083015 | Esophagus | ESCC | cellular response to leukemia inhibitory factor | 59/8552 | 94/18723 | 6.19e-04 | 3.32e-03 | 59 |
GO:19908237 | Oral cavity | OSCC | response to leukemia inhibitory factor | 58/7305 | 95/18723 | 1.10e-05 | 1.14e-04 | 58 |
GO:19908307 | Oral cavity | OSCC | cellular response to leukemia inhibitory factor | 57/7305 | 94/18723 | 1.75e-05 | 1.71e-04 | 57 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ADAM23 | SNV | Missense_Mutation | c.1120N>G | p.Lys374Glu | p.K374E | O75077 | protein_coding | deleterious(0.01) | probably_damaging(0.994) | TCGA-BS-A0UF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ADAM23 | SNV | Missense_Mutation | c.878G>A | p.Gly293Asp | p.G293D | O75077 | protein_coding | tolerated(0.39) | benign(0.017) | TCGA-BS-A0UV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
ADAM23 | SNV | Missense_Mutation | rs778780969 | c.947N>A | p.Arg316His | p.R316H | O75077 | protein_coding | deleterious(0.01) | probably_damaging(0.989) | TCGA-BS-A0VI-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ADAM23 | SNV | Missense_Mutation | c.514N>G | p.Leu172Val | p.L172V | O75077 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ADAM23 | SNV | Missense_Mutation | rs761701093 | c.2135N>T | p.Thr712Met | p.T712M | O75077 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-D1-A17T-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ADAM23 | SNV | Missense_Mutation | rs779781736 | c.859G>A | p.Ala287Thr | p.A287T | O75077 | protein_coding | tolerated(0.57) | benign(0.04) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
ADAM23 | SNV | Missense_Mutation | rs540276873 | c.1528G>A | p.Val510Met | p.V510M | O75077 | protein_coding | deleterious(0.03) | possibly_damaging(0.714) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
ADAM23 | SNV | Missense_Mutation | novel | c.2020C>T | p.Leu674Phe | p.L674F | O75077 | protein_coding | deleterious(0) | probably_damaging(0.961) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
ADAM23 | SNV | Missense_Mutation | novel | c.1948N>C | p.Cys650Arg | p.C650R | O75077 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-DI-A1BU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
ADAM23 | SNV | Missense_Mutation | c.1936N>T | p.Arg646Trp | p.R646W | O75077 | protein_coding | deleterious(0.03) | probably_damaging(0.97) | TCGA-DI-A2QU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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