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Gene: ADAM15 |
Gene summary for ADAM15 |
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Gene information | Species | Human | Gene symbol | ADAM15 | Gene ID | 8751 |
Gene name | ADAM metallopeptidase domain 15 | |
Gene Alias | MDC15 | |
Cytomap | 1q21.3 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q13444 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8751 | ADAM15 | LZE2T | Human | Esophagus | ESCC | 6.19e-05 | 8.92e-01 | 0.082 |
8751 | ADAM15 | LZE4T | Human | Esophagus | ESCC | 1.49e-09 | 1.84e-01 | 0.0811 |
8751 | ADAM15 | LZE5T | Human | Esophagus | ESCC | 2.39e-08 | 2.20e-01 | 0.0514 |
8751 | ADAM15 | LZE7T | Human | Esophagus | ESCC | 3.92e-11 | 3.93e-01 | 0.0667 |
8751 | ADAM15 | LZE8T | Human | Esophagus | ESCC | 1.51e-08 | 1.12e-01 | 0.067 |
8751 | ADAM15 | LZE20T | Human | Esophagus | ESCC | 2.05e-04 | 3.22e-01 | 0.0662 |
8751 | ADAM15 | LZE22D1 | Human | Esophagus | HGIN | 2.76e-04 | 1.32e-01 | 0.0595 |
8751 | ADAM15 | LZE22T | Human | Esophagus | ESCC | 2.18e-03 | 5.32e-01 | 0.068 |
8751 | ADAM15 | LZE24T | Human | Esophagus | ESCC | 2.88e-31 | 7.43e-01 | 0.0596 |
8751 | ADAM15 | LZE21T | Human | Esophagus | ESCC | 1.64e-07 | 5.67e-01 | 0.0655 |
8751 | ADAM15 | P1T-E | Human | Esophagus | ESCC | 1.65e-24 | 1.11e+00 | 0.0875 |
8751 | ADAM15 | P2T-E | Human | Esophagus | ESCC | 9.70e-33 | 7.43e-01 | 0.1177 |
8751 | ADAM15 | P4T-E | Human | Esophagus | ESCC | 3.59e-22 | 4.17e-01 | 0.1323 |
8751 | ADAM15 | P5T-E | Human | Esophagus | ESCC | 4.04e-32 | 6.99e-01 | 0.1327 |
8751 | ADAM15 | P8T-E | Human | Esophagus | ESCC | 1.54e-16 | 4.70e-01 | 0.0889 |
8751 | ADAM15 | P9T-E | Human | Esophagus | ESCC | 1.82e-20 | 4.89e-01 | 0.1131 |
8751 | ADAM15 | P10T-E | Human | Esophagus | ESCC | 1.97e-13 | 1.77e-01 | 0.116 |
8751 | ADAM15 | P11T-E | Human | Esophagus | ESCC | 8.50e-26 | 8.83e-01 | 0.1426 |
8751 | ADAM15 | P12T-E | Human | Esophagus | ESCC | 8.80e-19 | 4.90e-01 | 0.1122 |
8751 | ADAM15 | P15T-E | Human | Esophagus | ESCC | 2.37e-46 | 1.03e+00 | 0.1149 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:002241120 | Esophagus | HGIN | cellular component disassembly | 102/2587 | 443/18723 | 8.31e-08 | 4.33e-06 | 102 |
GO:007048220 | Esophagus | HGIN | response to oxygen levels | 76/2587 | 347/18723 | 2.36e-05 | 6.25e-04 | 76 |
GO:190165420 | Esophagus | HGIN | response to ketone | 48/2587 | 194/18723 | 3.17e-05 | 8.12e-04 | 48 |
GO:005109825 | Esophagus | HGIN | regulation of binding | 78/2587 | 363/18723 | 3.73e-05 | 9.30e-04 | 78 |
GO:003629320 | Esophagus | HGIN | response to decreased oxygen levels | 70/2587 | 322/18723 | 6.23e-05 | 1.44e-03 | 70 |
GO:000166620 | Esophagus | HGIN | response to hypoxia | 67/2587 | 307/18723 | 7.82e-05 | 1.75e-03 | 67 |
GO:001604919 | Esophagus | HGIN | cell growth | 93/2587 | 482/18723 | 4.49e-04 | 6.62e-03 | 93 |
GO:009730520 | Esophagus | HGIN | response to alcohol | 54/2587 | 253/18723 | 6.46e-04 | 8.87e-03 | 54 |
GO:003209110 | Esophagus | HGIN | negative regulation of protein binding | 23/2587 | 94/18723 | 3.92e-03 | 3.54e-02 | 23 |
GO:005110020 | Esophagus | HGIN | negative regulation of binding | 35/2587 | 162/18723 | 4.32e-03 | 3.84e-02 | 35 |
GO:000155818 | Esophagus | HGIN | regulation of cell growth | 76/2587 | 414/18723 | 5.40e-03 | 4.42e-02 | 76 |
GO:006145819 | Esophagus | HGIN | reproductive system development | 78/2587 | 427/18723 | 5.53e-03 | 4.52e-02 | 78 |
GO:0022411111 | Esophagus | ESCC | cellular component disassembly | 305/8552 | 443/18723 | 1.94e-23 | 4.57e-21 | 305 |
GO:0051098111 | Esophagus | ESCC | regulation of binding | 251/8552 | 363/18723 | 6.73e-20 | 8.46e-18 | 251 |
GO:004339320 | Esophagus | ESCC | regulation of protein binding | 135/8552 | 196/18723 | 3.69e-11 | 1.22e-09 | 135 |
GO:0070482111 | Esophagus | ESCC | response to oxygen levels | 218/8552 | 347/18723 | 6.91e-11 | 2.17e-09 | 218 |
GO:0016049110 | Esophagus | ESCC | cell growth | 289/8552 | 482/18723 | 1.29e-10 | 3.77e-09 | 289 |
GO:0036293111 | Esophagus | ESCC | response to decreased oxygen levels | 201/8552 | 322/18723 | 8.37e-10 | 2.04e-08 | 201 |
GO:0001666111 | Esophagus | ESCC | response to hypoxia | 192/8552 | 307/18723 | 1.59e-09 | 3.69e-08 | 192 |
GO:000155819 | Esophagus | ESCC | regulation of cell growth | 248/8552 | 414/18723 | 2.97e-09 | 6.45e-08 | 248 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ADAM15 | SNV | Missense_Mutation | c.1375N>T | p.Ala459Ser | p.A459S | Q13444 | protein_coding | deleterious(0.02) | possibly_damaging(0.816) | TCGA-55-A493-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ADAM15 | SNV | Missense_Mutation | novel | c.1708N>G | p.Ser570Ala | p.S570A | Q13444 | protein_coding | tolerated(0.07) | benign(0.314) | TCGA-L4-A4E5-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ADAM15 | SNV | Missense_Mutation | novel | c.763N>C | p.Val255Leu | p.V255L | Q13444 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-34-2609-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | gemcitabine | PD |
ADAM15 | SNV | Missense_Mutation | novel | c.1249C>G | p.Leu417Val | p.L417V | Q13444 | protein_coding | tolerated(0.42) | possibly_damaging(0.762) | TCGA-43-2581-01 | Lung | lung squamous cell carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
ADAM15 | SNV | Missense_Mutation | novel | c.2423A>G | p.Lys808Arg | p.K808R | Q13444 | protein_coding | tolerated(0.09) | benign(0.388) | TCGA-56-8309-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ADAM15 | SNV | Missense_Mutation | novel | c.2424G>T | p.Lys808Asn | p.K808N | Q13444 | protein_coding | deleterious(0.01) | possibly_damaging(0.738) | TCGA-56-8309-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ADAM15 | SNV | Missense_Mutation | novel | c.2365G>A | p.Asp789Asn | p.D789N | Q13444 | protein_coding | tolerated(0.1) | probably_damaging(0.998) | TCGA-85-A4CL-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ADAM15 | SNV | Missense_Mutation | novel | c.1697N>T | p.Gly566Val | p.G566V | Q13444 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-96-7545-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
ADAM15 | deletion | Frame_Shift_Del | c.154delN | p.Asp52IlefsTer18 | p.D52Ifs*18 | Q13444 | protein_coding | TCGA-NJ-A4YI-01 | Lung | lung adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |||
ADAM15 | SNV | Missense_Mutation | rs773958488 | c.460N>C | p.Glu154Gln | p.E154Q | Q13444 | protein_coding | tolerated(0.08) | probably_damaging(0.948) | TCGA-BA-5152-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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