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Gene: ACTR5 |
Gene summary for ACTR5 |
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Gene information | Species | Human | Gene symbol | ACTR5 | Gene ID | 79913 |
Gene name | actin related protein 5 | |
Gene Alias | Arp5 | |
Cytomap | 20q11.23 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q9H9F9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79913 | ACTR5 | LZE24T | Human | Esophagus | ESCC | 5.67e-12 | 3.19e-01 | 0.0596 |
79913 | ACTR5 | P2T-E | Human | Esophagus | ESCC | 3.59e-10 | 1.68e-01 | 0.1177 |
79913 | ACTR5 | P4T-E | Human | Esophagus | ESCC | 6.59e-08 | 1.99e-01 | 0.1323 |
79913 | ACTR5 | P5T-E | Human | Esophagus | ESCC | 8.85e-05 | 1.22e-01 | 0.1327 |
79913 | ACTR5 | P8T-E | Human | Esophagus | ESCC | 1.61e-04 | 1.51e-01 | 0.0889 |
79913 | ACTR5 | P10T-E | Human | Esophagus | ESCC | 8.48e-13 | 1.85e-01 | 0.116 |
79913 | ACTR5 | P11T-E | Human | Esophagus | ESCC | 2.23e-03 | 1.51e-01 | 0.1426 |
79913 | ACTR5 | P12T-E | Human | Esophagus | ESCC | 8.25e-19 | 3.38e-01 | 0.1122 |
79913 | ACTR5 | P15T-E | Human | Esophagus | ESCC | 8.38e-15 | 2.84e-01 | 0.1149 |
79913 | ACTR5 | P16T-E | Human | Esophagus | ESCC | 5.56e-06 | 1.66e-01 | 0.1153 |
79913 | ACTR5 | P17T-E | Human | Esophagus | ESCC | 1.18e-02 | 1.96e-01 | 0.1278 |
79913 | ACTR5 | P20T-E | Human | Esophagus | ESCC | 3.22e-21 | 3.85e-01 | 0.1124 |
79913 | ACTR5 | P21T-E | Human | Esophagus | ESCC | 3.72e-17 | 4.06e-01 | 0.1617 |
79913 | ACTR5 | P22T-E | Human | Esophagus | ESCC | 1.65e-02 | 5.23e-02 | 0.1236 |
79913 | ACTR5 | P23T-E | Human | Esophagus | ESCC | 2.13e-08 | 2.31e-01 | 0.108 |
79913 | ACTR5 | P24T-E | Human | Esophagus | ESCC | 2.26e-07 | 1.87e-01 | 0.1287 |
79913 | ACTR5 | P26T-E | Human | Esophagus | ESCC | 3.36e-16 | 3.83e-01 | 0.1276 |
79913 | ACTR5 | P27T-E | Human | Esophagus | ESCC | 4.18e-06 | 1.39e-01 | 0.1055 |
79913 | ACTR5 | P28T-E | Human | Esophagus | ESCC | 4.89e-06 | 1.60e-01 | 0.1149 |
79913 | ACTR5 | P30T-E | Human | Esophagus | ESCC | 2.81e-03 | 1.37e-01 | 0.137 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000941113 | Esophagus | ESCC | response to UV | 115/8552 | 149/18723 | 3.29e-15 | 1.93e-13 | 115 |
GO:000931419 | Esophagus | ESCC | response to radiation | 277/8552 | 456/18723 | 4.42e-11 | 1.43e-09 | 277 |
GO:003464413 | Esophagus | ESCC | cellular response to UV | 70/8552 | 90/18723 | 4.59e-10 | 1.20e-08 | 70 |
GO:007121419 | Esophagus | ESCC | cellular response to abiotic stimulus | 206/8552 | 331/18723 | 7.52e-10 | 1.88e-08 | 206 |
GO:010400419 | Esophagus | ESCC | cellular response to environmental stimulus | 206/8552 | 331/18723 | 7.52e-10 | 1.88e-08 | 206 |
GO:007147816 | Esophagus | ESCC | cellular response to radiation | 122/8552 | 186/18723 | 3.07e-08 | 5.73e-07 | 122 |
GO:000632517 | Esophagus | ESCC | chromatin organization | 240/8552 | 409/18723 | 6.52e-08 | 1.14e-06 | 240 |
GO:00063024 | Esophagus | ESCC | double-strand break repair | 152/8552 | 251/18723 | 1.33e-06 | 1.62e-05 | 152 |
GO:000941611 | Esophagus | ESCC | response to light stimulus | 183/8552 | 320/18723 | 2.03e-05 | 1.76e-04 | 183 |
GO:00714821 | Esophagus | ESCC | cellular response to light stimulus | 75/8552 | 123/18723 | 4.45e-04 | 2.50e-03 | 75 |
GO:00063101 | Esophagus | ESCC | DNA recombination | 168/8552 | 305/18723 | 5.58e-04 | 3.05e-03 | 168 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ACTR5 | SNV | Missense_Mutation | c.421N>T | p.Pro141Ser | p.P141S | Q9H9F9 | protein_coding | deleterious(0) | possibly_damaging(0.767) | TCGA-BR-7851-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ACTR5 | SNV | Missense_Mutation | c.857N>A | p.Gly286Asp | p.G286D | Q9H9F9 | protein_coding | tolerated(0.09) | possibly_damaging(0.882) | TCGA-BR-8361-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
ACTR5 | SNV | Missense_Mutation | c.856G>A | p.Gly286Ser | p.G286S | Q9H9F9 | protein_coding | tolerated(0.29) | benign(0.21) | TCGA-BR-8680-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | CR | |
ACTR5 | SNV | Missense_Mutation | c.451N>T | p.Leu151Phe | p.L151F | Q9H9F9 | protein_coding | deleterious(0.03) | benign(0.096) | TCGA-CD-A4MG-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
ACTR5 | SNV | Missense_Mutation | novel | c.1086N>C | p.Gln362His | p.Q362H | Q9H9F9 | protein_coding | tolerated(0.56) | benign(0.001) | TCGA-VQ-A91S-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | fluorouracil | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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