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Gene: MUC17 |
Gene summary for MUC17 |
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Gene information | Species | Human | Gene symbol | MUC17 | Gene ID | 140453 |
Gene name | mucin 17, cell surface associated | |
Gene Alias | MUC-17 | |
Cytomap | 7q22.1 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | Q685J3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
140453 | MUC17 | HTA11_2487_2000001011 | Human | Colorectum | SER | 3.48e-06 | 1.16e+00 | -0.1808 |
140453 | MUC17 | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.03e-05 | 4.70e-01 | -0.0811 |
140453 | MUC17 | HTA11_411_2000001011 | Human | Colorectum | SER | 2.93e-04 | 2.05e+00 | -0.2602 |
140453 | MUC17 | HTA11_2112_2000001011 | Human | Colorectum | SER | 2.40e-05 | 1.44e+00 | -0.2196 |
140453 | MUC17 | HTA11_7696_3000711011 | Human | Colorectum | AD | 2.12e-02 | -1.38e-01 | 0.0674 |
140453 | MUC17 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 2.38e-03 | -1.42e-01 | 0.3859 |
140453 | MUC17 | A015-C-203 | Human | Colorectum | FAP | 2.05e-02 | -1.36e-01 | -0.1294 |
140453 | MUC17 | A002-C-201 | Human | Colorectum | FAP | 1.71e-02 | -1.46e-01 | 0.0324 |
140453 | MUC17 | A002-C-203 | Human | Colorectum | FAP | 7.57e-03 | -1.37e-01 | 0.2786 |
140453 | MUC17 | A001-C-108 | Human | Colorectum | FAP | 1.92e-04 | -1.40e-01 | -0.0272 |
140453 | MUC17 | A015-C-106 | Human | Colorectum | FAP | 3.19e-04 | -1.20e-01 | -0.0511 |
140453 | MUC17 | A015-C-202 | Human | Colorectum | FAP | 1.83e-02 | -1.46e-01 | -0.0849 |
140453 | MUC17 | A001-C-203 | Human | Colorectum | FAP | 3.34e-02 | -1.31e-01 | -0.0481 |
140453 | MUC17 | A002-C-116 | Human | Colorectum | FAP | 2.00e-05 | -1.39e-01 | -0.0452 |
140453 | MUC17 | F034 | Human | Colorectum | FAP | 4.21e-02 | -1.31e-01 | -0.0665 |
140453 | MUC17 | CRC-3-11773 | Human | Colorectum | CRC | 2.60e-02 | -1.15e-01 | 0.2564 |
140453 | MUC17 | Pat01-B | Human | Stomach | GC | 5.32e-84 | 1.37e+00 | 0.5754 |
140453 | MUC17 | Pat02-B | Human | Stomach | GC | 1.54e-25 | 5.48e-01 | 0.0368 |
140453 | MUC17 | Pat03-B | Human | Stomach | GC | 1.41e-42 | 1.00e+00 | 0.3693 |
140453 | MUC17 | Pat05-B | Human | Stomach | GC | 6.46e-04 | 2.62e-01 | -0.0353 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MUC17 | SNV | Missense_Mutation | novel | c.12955A>C | p.Lys4319Gln | p.K4319Q | Q685J3 | protein_coding | tolerated(0.28) | benign(0.006) | TCGA-77-8128-01 | Lung | lung squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
MUC17 | SNV | Missense_Mutation | novel | c.7318N>T | p.Thr2440Ser | p.T2440S | Q685J3 | protein_coding | tolerated(0.19) | possibly_damaging(0.636) | TCGA-77-8156-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
MUC17 | SNV | Missense_Mutation | rs774669284 | c.9268N>T | p.Ala3090Ser | p.A3090S | Q685J3 | protein_coding | tolerated(0.4) | probably_damaging(0.935) | TCGA-77-8156-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
MUC17 | SNV | Missense_Mutation | c.400N>A | p.Glu134Lys | p.E134K | Q685J3 | protein_coding | deleterious_low_confidence(0.03) | benign(0.054) | TCGA-77-A5G3-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
MUC17 | SNV | Missense_Mutation | novel | c.1187N>A | p.Thr396Lys | p.T396K | Q685J3 | protein_coding | deleterious(0) | benign(0.042) | TCGA-77-A5G3-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
MUC17 | SNV | Missense_Mutation | c.4799C>A | p.Ser1600Tyr | p.S1600Y | Q685J3 | protein_coding | tolerated(0.06) | benign(0.078) | TCGA-77-A5G8-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
MUC17 | SNV | Missense_Mutation | c.3671T>C | p.Met1224Thr | p.M1224T | Q685J3 | protein_coding | tolerated(0.56) | benign(0.017) | TCGA-85-6560-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | SD | |
MUC17 | SNV | Missense_Mutation | novel | c.3624N>A | p.Ser1208Arg | p.S1208R | Q685J3 | protein_coding | deleterious(0.04) | benign(0.019) | TCGA-85-7696-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
MUC17 | SNV | Missense_Mutation | novel | c.1991N>A | p.Thr664Asn | p.T664N | Q685J3 | protein_coding | tolerated(0.05) | benign(0.027) | TCGA-85-8288-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
MUC17 | SNV | Missense_Mutation | novel | c.2246N>C | p.Leu749Ser | p.L749S | Q685J3 | protein_coding | tolerated(0.17) | benign(0.007) | TCGA-85-8351-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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