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Gene: ZFHX4 |
Gene summary for ZFHX4 |
Gene summary. |
Gene information | Species | Human | Gene symbol | ZFHX4 | Gene ID | 79776 |
Gene name | zinc finger homeobox 4 | |
Gene Alias | ZFH4 | |
Cytomap | 8q21.13 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q86UP3 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79776 | ZFHX4 | P1T-E | Human | Esophagus | ESCC | 5.20e-08 | 3.43e-01 | 0.0875 |
79776 | ZFHX4 | P5T-E | Human | Esophagus | ESCC | 3.76e-04 | 9.90e-02 | 0.1327 |
79776 | ZFHX4 | P9T-E | Human | Esophagus | ESCC | 5.23e-05 | 1.38e-01 | 0.1131 |
79776 | ZFHX4 | P10T-E | Human | Esophagus | ESCC | 3.29e-21 | 4.45e-01 | 0.116 |
79776 | ZFHX4 | P11T-E | Human | Esophagus | ESCC | 3.25e-05 | 2.03e-01 | 0.1426 |
79776 | ZFHX4 | P15T-E | Human | Esophagus | ESCC | 8.45e-04 | 1.24e-01 | 0.1149 |
79776 | ZFHX4 | P16T-E | Human | Esophagus | ESCC | 2.22e-05 | 8.99e-02 | 0.1153 |
79776 | ZFHX4 | P23T-E | Human | Esophagus | ESCC | 6.91e-16 | 4.27e-01 | 0.108 |
79776 | ZFHX4 | P24T-E | Human | Esophagus | ESCC | 8.72e-07 | 1.08e-01 | 0.1287 |
79776 | ZFHX4 | P26T-E | Human | Esophagus | ESCC | 1.63e-05 | 1.11e-01 | 0.1276 |
79776 | ZFHX4 | P27T-E | Human | Esophagus | ESCC | 8.49e-09 | 2.07e-01 | 0.1055 |
79776 | ZFHX4 | P30T-E | Human | Esophagus | ESCC | 2.31e-10 | 3.75e-01 | 0.137 |
79776 | ZFHX4 | P36T-E | Human | Esophagus | ESCC | 4.17e-05 | 2.13e-01 | 0.1187 |
79776 | ZFHX4 | P37T-E | Human | Esophagus | ESCC | 3.53e-03 | 1.09e-01 | 0.1371 |
79776 | ZFHX4 | P42T-E | Human | Esophagus | ESCC | 1.02e-24 | 6.57e-01 | 0.1175 |
79776 | ZFHX4 | P47T-E | Human | Esophagus | ESCC | 1.94e-02 | 6.53e-02 | 0.1067 |
79776 | ZFHX4 | P49T-E | Human | Esophagus | ESCC | 3.75e-07 | 6.69e-01 | 0.1768 |
79776 | ZFHX4 | P62T-E | Human | Esophagus | ESCC | 1.57e-81 | 1.32e+00 | 0.1302 |
79776 | ZFHX4 | P74T-E | Human | Esophagus | ESCC | 2.69e-24 | 5.65e-01 | 0.1479 |
79776 | ZFHX4 | P75T-E | Human | Esophagus | ESCC | 2.25e-19 | 3.95e-01 | 0.1125 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZFHX4 | SNV | Missense_Mutation | c.8459N>C | p.Asn2820Thr | p.N2820T | Q86UP3 | protein_coding | deleterious(0.01) | benign(0.127) | TCGA-DD-A4NQ-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Targeted Molecular therapy | sorafenib | PD | |
ZFHX4 | SNV | Missense_Mutation | novel | c.1464N>C | p.Leu488Phe | p.L488F | Q86UP3 | protein_coding | tolerated_low_confidence(0.19) | possibly_damaging(0.656) | TCGA-DD-AAC8-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ZFHX4 | SNV | Missense_Mutation | rs760554402 | c.7280N>T | p.Pro2427Leu | p.P2427L | Q86UP3 | protein_coding | tolerated_low_confidence(0.08) | benign(0) | TCGA-DD-AAC8-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ZFHX4 | SNV | Missense_Mutation | novel | c.7919N>T | p.Arg2640Leu | p.R2640L | Q86UP3 | protein_coding | deleterious(0.01) | possibly_damaging(0.582) | TCGA-DD-AACA-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
ZFHX4 | SNV | Missense_Mutation | novel | c.7379N>T | p.Gly2460Val | p.G2460V | Q86UP3 | protein_coding | tolerated_low_confidence(0.16) | possibly_damaging(0.663) | TCGA-DD-AACU-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ZFHX4 | SNV | Missense_Mutation | novel | c.1071N>G | p.Asp357Glu | p.D357E | Q86UP3 | protein_coding | deleterious_low_confidence(0.02) | probably_damaging(0.99) | TCGA-DD-AADW-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
ZFHX4 | SNV | Missense_Mutation | rs779366252 | c.8988N>A | p.Met2996Ile | p.M2996I | Q86UP3 | protein_coding | tolerated(0.34) | probably_damaging(0.956) | TCGA-G3-A7M9-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
ZFHX4 | insertion | Frame_Shift_Ins | novel | c.6883_6884insA | p.Arg2297LysfsTer5 | p.R2297Kfs*5 | Q86UP3 | protein_coding | TCGA-CC-A3MC-01 | Liver | liver hepatocellular carcinoma | Male | <65 | III/IV | Unknown | Unknown | PD | ||
ZFHX4 | insertion | Frame_Shift_Ins | novel | c.4594_4595insAA | p.Phe1534AsnfsTer37 | p.F1534Nfs*37 | Q86UP3 | protein_coding | TCGA-DD-AADW-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | PD | ||
ZFHX4 | deletion | Frame_Shift_Del | novel | c.4867_4874delNNNNNNNN | p.Ala1624GlyfsTer46 | p.A1624Gfs*46 | Q86UP3 | protein_coding | TCGA-DD-AADW-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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