Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: FAT1

Gene summary for FAT1

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

FAT1

Gene ID

2195

Gene nameFAT atypical cadherin 1
Gene AliasCDHF7
Cytomap4q35.2
Gene Typeprotein-coding
GO ID

GO:0000902

UniProtAcc

Q14517


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
2195FAT1CA_HPV_1HumanCervixCC5.98e-15-3.11e-010.0264
2195FAT1CCI_3HumanCervixCC1.19e-058.23e-010.516
2195FAT1T1HumanCervixCC8.35e-043.31e-010.0918
2195FAT1HTA11_3410_2000001011HumanColorectumAD2.57e-15-5.42e-010.0155
2195FAT1HTA11_3361_2000001011HumanColorectumAD2.35e-03-5.50e-01-0.1207
2195FAT1HTA11_99999971662_82457HumanColorectumMSS5.36e-035.78e-010.3859
2195FAT1HTA11_99999974143_84620HumanColorectumMSS1.39e-03-3.73e-010.3005
2195FAT1F007HumanColorectumFAP1.81e-031.49e-010.1176
2195FAT1A002-C-010HumanColorectumFAP6.29e-033.65e-020.242
2195FAT1A001-C-207HumanColorectumFAP1.14e-044.28e-020.1278
2195FAT1A015-C-203HumanColorectumFAP1.38e-32-4.57e-02-0.1294
2195FAT1A015-C-204HumanColorectumFAP1.72e-06-1.83e-01-0.0228
2195FAT1A014-C-040HumanColorectumFAP1.94e-05-7.64e-02-0.1184
2195FAT1A002-C-201HumanColorectumFAP5.22e-16-3.65e-020.0324
2195FAT1A002-C-203HumanColorectumFAP1.89e-02-2.00e-020.2786
2195FAT1A001-C-119HumanColorectumFAP3.69e-07-2.78e-02-0.1557
2195FAT1A001-C-108HumanColorectumFAP5.20e-202.08e-01-0.0272
2195FAT1A002-C-021HumanColorectumFAP3.10e-023.32e-010.1171
2195FAT1A002-C-205HumanColorectumFAP4.87e-332.56e-01-0.1236
2195FAT1A001-C-104HumanColorectumFAP2.64e-072.02e-010.0184
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
CervixThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CC: Cervix cancer
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions
N_HPV: HPV-infected normal cervix
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
GCThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CAG: Chronic atrophic gastritis
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia
CSG: Chronic superficial gastritis
GC: Gastric cancer
SIM: Severe intestinal metaplasia
WIM: Wild intestinal metaplasia
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:000701510CervixCCactin filament organization109/2311442/187234.92e-132.45e-10109
GO:00071639CervixCCestablishment or maintenance of cell polarity63/2311218/187234.25e-118.76e-0963
GO:00300108CervixCCestablishment of cell polarity42/2311143/187234.30e-082.62e-0642
GO:000206410CervixCCepithelial cell development45/2311220/187234.14e-044.21e-0345
GO:00901627CervixCCestablishment of epithelial cell polarity11/231131/187237.87e-046.96e-0311
GO:00017384CervixCCmorphogenesis of a polarized epithelium22/231194/187232.09e-031.52e-0222
GO:0150063CervixCCvisual system development63/2311375/187236.58e-033.65e-0263
GO:0001654CervixCCeye development62/2311371/187237.83e-034.13e-0262
GO:0048880CervixCCsensory system development63/2311381/187239.29e-034.66e-0263
GO:0007015ColorectumADactin filament organization167/3918442/187231.65e-167.94e-14167
GO:0002064ColorectumADepithelial cell development89/3918220/187232.98e-113.52e-0989
GO:0007163ColorectumADestablishment or maintenance of cell polarity77/3918218/187235.72e-072.08e-0577
GO:0030010ColorectumADestablishment of cell polarity50/3918143/187236.90e-051.11e-0350
GO:0045197ColorectumADestablishment or maintenance of epithelial cell apical/basal polarity20/391844/187232.26e-042.94e-0320
GO:0035088ColorectumADestablishment or maintenance of apical/basal cell polarity21/391849/187234.31e-044.82e-0321
GO:0061245ColorectumADestablishment or maintenance of bipolar cell polarity21/391849/187234.31e-044.82e-0321
GO:0001738ColorectumADmorphogenesis of a polarized epithelium31/391894/187234.30e-032.95e-0231
GO:0030859ColorectumADpolarized epithelial cell differentiation11/391824/187235.43e-033.55e-0211
GO:0090162ColorectumADestablishment of epithelial cell polarity13/391831/187236.53e-034.06e-0213
GO:00070152ColorectumMSSactin filament organization146/3467442/187231.16e-132.67e-11146
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
FAT1insertionFrame_Shift_Insnovelc.5065_5066insGGp.Val1689GlyfsTer14p.V1689Gfs*14Q14517protein_codingTCGA-DQ-5629-01Oral cavityhead & neck squamous cell carcinomaMale<65I/IIChemotherapycarboplatinSD
FAT1insertionFrame_Shift_Insnovelc.9994dupAp.Thr3332AsnfsTer15p.T3332Nfs*15Q14517protein_codingTCGA-DQ-7592-01Oral cavityhead & neck squamous cell carcinomaMale<65I/IIChemotherapycisplatinSD
FAT1insertionFrame_Shift_Insnovelc.5648_5649insTp.Leu1883PhefsTer3p.L1883Ffs*3Q14517protein_codingTCGA-F7-8489-01Oral cavityhead & neck squamous cell carcinomaMale<65I/IIUnknownUnknownSD
FAT1insertionFrame_Shift_Insnovelc.4089_4090insTp.Thr1364TyrfsTer8p.T1364Yfs*8Q14517protein_codingTCGA-F7-A50I-01Oral cavityhead & neck squamous cell carcinomaMale>=65I/IIUnknownUnknownSD
FAT1deletionIn_Frame_Delnovelc.3514_3534delNNNNNNNNNNNNNNNNNNNNNp.Asp1172_Ile1178delp.D1172_I1178delQ14517protein_codingTCGA-F7-A61S-01Oral cavityhead & neck squamous cell carcinomaMale<65III/IVUnknownUnknownPD
FAT1insertionFrame_Shift_Insnovelc.819_820insTp.Ala274CysfsTer7p.A274Cfs*7Q14517protein_codingTCGA-F7-A622-01Oral cavityhead & neck squamous cell carcinomaMale>=65III/IVUnknownUnknownPD
FAT1deletionFrame_Shift_Delnovelc.10941_10947delNNNNNNNp.Ala3648SerfsTer24p.A3648Sfs*24Q14517protein_codingTCGA-HD-A6I0-01Oral cavityhead & neck squamous cell carcinomaMale<65I/IIUnknownUnknownSD
FAT1insertionFrame_Shift_Insnovelc.1640_1641insTAp.Arg548ThrfsTer16p.R548Tfs*16Q14517protein_codingTCGA-HD-A6I0-01Oral cavityhead & neck squamous cell carcinomaMale<65I/IIUnknownUnknownSD
FAT1deletionFrame_Shift_Delnovelc.7314_7320delNNNNNNNp.Phe2438LeufsTer18p.F2438Lfs*18Q14517protein_codingTCGA-IQ-A61E-01Oral cavityhead & neck squamous cell carcinomaFemale<65III/IVChemotherapycisplatinCR
FAT1deletionFrame_Shift_Delnovelc.5544_5565delNNNNNNNNNNNNNNNNNNNNNNp.Gln1848HisfsTer11p.Q1848Hfs*11Q14517protein_codingTCGA-UF-A7JJ-01Oral cavityhead & neck squamous cell carcinomaMale>=65I/IIChemotherapycisplatinCR
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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