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Gene: DNAH5 |
Gene summary for DNAH5 |
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Gene information | Species | Human | Gene symbol | DNAH5 | Gene ID | 1767 |
Gene name | dynein axonemal heavy chain 5 | |
Gene Alias | CILD3 | |
Cytomap | 5p15.2 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q8TE73 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1767 | DNAH5 | C04 | Human | Oral cavity | OSCC | 2.09e-35 | 1.82e+00 | 0.2633 |
1767 | DNAH5 | C21 | Human | Oral cavity | OSCC | 7.14e-04 | 1.57e-01 | 0.2678 |
1767 | DNAH5 | SYSMH2 | Human | Oral cavity | OSCC | 4.32e-07 | 6.58e-01 | 0.2326 |
1767 | DNAH5 | SYSMH3 | Human | Oral cavity | OSCC | 5.39e-16 | 7.09e-01 | 0.2442 |
1767 | DNAH5 | SYSMH5 | Human | Oral cavity | OSCC | 1.09e-26 | 1.05e+00 | 0.0647 |
1767 | DNAH5 | HTA12-25-1 | Human | Pancreas | PDAC | 2.50e-03 | 4.72e-01 | 0.313 |
1767 | DNAH5 | HTA12-26-1 | Human | Pancreas | PDAC | 4.34e-14 | 7.27e-01 | 0.3728 |
1767 | DNAH5 | HTA12-29-1 | Human | Pancreas | PDAC | 6.09e-12 | 3.98e-01 | 0.3722 |
1767 | DNAH5 | HTA12-32-1 | Human | Pancreas | PDAC | 1.20e-02 | 7.98e-01 | 0.3624 |
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Tissue | Expression Dynamics | Abbreviation |
Oral Cavity | ![]() | EOLP: Erosive Oral lichen planus |
LP: leukoplakia | ||
NEOLP: Non-erosive oral lichen planus | ||
OSCC: Oral squamous cell carcinoma |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00991113 | Oral cavity | OSCC | microtubule-based transport | 96/7305 | 190/18723 | 7.92e-04 | 4.27e-03 | 96 |
GO:0021591 | Oral cavity | OSCC | ventricular system development | 18/7305 | 29/18723 | 1.00e-02 | 3.49e-02 | 18 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0501428 | Oral cavity | OSCC | Amyotrophic lateral sclerosis | 246/3704 | 364/8465 | 6.65e-21 | 1.11e-18 | 5.67e-19 | 246 |
hsa0501628 | Oral cavity | OSCC | Huntington disease | 204/3704 | 306/8465 | 1.70e-16 | 7.13e-15 | 3.63e-15 | 204 |
hsa0502228 | Oral cavity | OSCC | Pathways of neurodegeneration - multiple diseases | 292/3704 | 476/8465 | 1.60e-15 | 4.47e-14 | 2.28e-14 | 292 |
hsa05014112 | Oral cavity | OSCC | Amyotrophic lateral sclerosis | 246/3704 | 364/8465 | 6.65e-21 | 1.11e-18 | 5.67e-19 | 246 |
hsa05016112 | Oral cavity | OSCC | Huntington disease | 204/3704 | 306/8465 | 1.70e-16 | 7.13e-15 | 3.63e-15 | 204 |
hsa05022112 | Oral cavity | OSCC | Pathways of neurodegeneration - multiple diseases | 292/3704 | 476/8465 | 1.60e-15 | 4.47e-14 | 2.28e-14 | 292 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DNAH5 | SNV | Missense_Mutation | c.1687N>G | p.Gln563Glu | p.Q563E | Q8TE73 | protein_coding | tolerated(0.27) | benign(0.04) | TCGA-NJ-A4YP-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
DNAH5 | SNV | Missense_Mutation | novel | c.9366N>C | p.Leu3122Phe | p.L3122F | Q8TE73 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-NJ-A4YQ-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
DNAH5 | SNV | Missense_Mutation | novel | c.7993N>T | p.Asn2665Tyr | p.N2665Y | Q8TE73 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-NJ-A4YQ-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
DNAH5 | SNV | Missense_Mutation | c.11443G>A | p.Glu3815Lys | p.E3815K | Q8TE73 | protein_coding | deleterious(0) | probably_damaging(0.928) | TCGA-18-3409-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
DNAH5 | SNV | Missense_Mutation | c.10963G>A | p.Glu3655Lys | p.E3655K | Q8TE73 | protein_coding | deleterious(0) | probably_damaging(0.981) | TCGA-18-3409-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
DNAH5 | SNV | Missense_Mutation | c.6718C>A | p.Pro2240Thr | p.P2240T | Q8TE73 | protein_coding | tolerated(0.09) | benign(0.08) | TCGA-18-3409-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
DNAH5 | SNV | Missense_Mutation | c.12277N>G | p.Asn4093Asp | p.N4093D | Q8TE73 | protein_coding | tolerated(0.47) | benign(0.007) | TCGA-18-3411-01 | Lung | lung squamous cell carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
DNAH5 | SNV | Missense_Mutation | c.1441N>A | p.Ala481Thr | p.A481T | Q8TE73 | protein_coding | tolerated(0.29) | benign(0.01) | TCGA-18-3411-01 | Lung | lung squamous cell carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
DNAH5 | SNV | Missense_Mutation | c.13045N>T | p.Asp4349Tyr | p.D4349Y | Q8TE73 | protein_coding | deleterious(0) | benign(0.288) | TCGA-18-3414-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
DNAH5 | SNV | Missense_Mutation | c.1012N>G | p.Thr338Ala | p.T338A | Q8TE73 | protein_coding | tolerated(1) | benign(0) | TCGA-18-3417-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Chemotherapy | cisplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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