![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: APOB |
Gene summary for APOB |
![]() |
Gene information | Species | Human | Gene symbol | APOB | Gene ID | 338 |
Gene name | apolipoprotein B | |
Gene Alias | FCHL2 | |
Cytomap | 2p24.1 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | P04114 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
338 | APOB | NAFLD1 | Human | Liver | NAFLD | 1.00e-15 | 1.50e+00 | -0.04 |
338 | APOB | S41 | Human | Liver | Cirrhotic | 2.30e-21 | 1.26e+00 | -0.0343 |
338 | APOB | S42 | Human | Liver | HCC | 3.93e-18 | 1.40e+00 | -0.0103 |
338 | APOB | S43 | Human | Liver | Cirrhotic | 1.05e-56 | 1.41e+00 | -0.0187 |
338 | APOB | S44 | Human | Liver | HCC | 7.35e-17 | 1.41e+00 | -0.0083 |
338 | APOB | HCC1_Meng | Human | Liver | HCC | 3.90e-68 | 1.10e+00 | 0.0246 |
338 | APOB | HCC2_Meng | Human | Liver | HCC | 3.85e-19 | -6.23e-01 | 0.0107 |
338 | APOB | cirrhotic1 | Human | Liver | Cirrhotic | 3.47e-15 | -2.44e-01 | 0.0202 |
338 | APOB | cirrhotic2 | Human | Liver | Cirrhotic | 1.83e-16 | -2.04e-02 | 0.0201 |
338 | APOB | cirrhotic3 | Human | Liver | Cirrhotic | 2.16e-02 | -2.73e-01 | 0.0215 |
338 | APOB | HCC1 | Human | Liver | HCC | 5.53e-43 | 8.67e+00 | 0.5336 |
338 | APOB | HCC2 | Human | Liver | HCC | 5.36e-57 | 8.64e+00 | 0.5341 |
338 | APOB | HCC5 | Human | Liver | HCC | 2.63e-27 | 6.30e+00 | 0.4932 |
338 | APOB | Pt13.a | Human | Liver | HCC | 3.43e-18 | 1.30e-01 | 0.021 |
338 | APOB | Pt13.b | Human | Liver | HCC | 6.31e-49 | 3.98e-01 | 0.0251 |
338 | APOB | Pt13.c | Human | Liver | HCC | 4.98e-04 | 3.55e-01 | 0.0076 |
338 | APOB | Pt14.a | Human | Liver | HCC | 4.23e-14 | 9.22e-01 | 0.0169 |
338 | APOB | Pt14.b | Human | Liver | HCC | 8.40e-18 | 4.51e-01 | 0.018 |
338 | APOB | Pt14.d | Human | Liver | HCC | 3.77e-21 | 2.58e-01 | 0.0143 |
338 | APOB | S014 | Human | Liver | HCC | 2.28e-13 | 2.15e+00 | 0.2254 |
Page: 1 2 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0016032 | Colorectum | AD | viral process | 168/3918 | 415/18723 | 4.67e-20 | 3.66e-17 | 168 |
GO:0019058 | Colorectum | AD | viral life cycle | 119/3918 | 317/18723 | 6.18e-12 | 8.23e-10 | 119 |
GO:0044270 | Colorectum | AD | cellular nitrogen compound catabolic process | 147/3918 | 451/18723 | 3.35e-09 | 2.23e-07 | 147 |
GO:0046700 | Colorectum | AD | heterocycle catabolic process | 145/3918 | 445/18723 | 4.37e-09 | 2.84e-07 | 145 |
GO:0034655 | Colorectum | AD | nucleobase-containing compound catabolic process | 133/3918 | 407/18723 | 1.56e-08 | 9.12e-07 | 133 |
GO:0019439 | Colorectum | AD | aromatic compound catabolic process | 146/3918 | 467/18723 | 7.48e-08 | 3.84e-06 | 146 |
GO:1901361 | Colorectum | AD | organic cyclic compound catabolic process | 153/3918 | 495/18723 | 8.23e-08 | 4.18e-06 | 153 |
GO:0044282 | Colorectum | AD | small molecule catabolic process | 118/3918 | 376/18723 | 1.05e-06 | 3.55e-05 | 118 |
GO:0019079 | Colorectum | AD | viral genome replication | 51/3918 | 131/18723 | 1.83e-06 | 5.51e-05 | 51 |
GO:0050792 | Colorectum | AD | regulation of viral process | 59/3918 | 164/18723 | 5.95e-06 | 1.52e-04 | 59 |
GO:1903900 | Colorectum | AD | regulation of viral life cycle | 51/3918 | 148/18723 | 9.01e-05 | 1.38e-03 | 51 |
GO:0045069 | Colorectum | AD | regulation of viral genome replication | 32/3918 | 85/18723 | 2.97e-04 | 3.60e-03 | 32 |
GO:00160321 | Colorectum | SER | viral process | 118/2897 | 415/18723 | 8.36e-12 | 1.65e-09 | 118 |
GO:00190581 | Colorectum | SER | viral life cycle | 87/2897 | 317/18723 | 2.82e-08 | 1.94e-06 | 87 |
GO:00442821 | Colorectum | SER | small molecule catabolic process | 87/2897 | 376/18723 | 5.31e-05 | 1.27e-03 | 87 |
GO:00190791 | Colorectum | SER | viral genome replication | 37/2897 | 131/18723 | 1.36e-04 | 2.72e-03 | 37 |
GO:00442701 | Colorectum | SER | cellular nitrogen compound catabolic process | 99/2897 | 451/18723 | 1.46e-04 | 2.86e-03 | 99 |
GO:00467001 | Colorectum | SER | heterocycle catabolic process | 97/2897 | 445/18723 | 2.20e-04 | 3.89e-03 | 97 |
GO:00507921 | Colorectum | SER | regulation of viral process | 43/2897 | 164/18723 | 2.57e-04 | 4.31e-03 | 43 |
GO:19013611 | Colorectum | SER | organic cyclic compound catabolic process | 104/2897 | 495/18723 | 5.46e-04 | 7.63e-03 | 104 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa049796 | Liver | NAFLD | Cholesterol metabolism | 20/1043 | 51/8465 | 9.73e-07 | 4.56e-05 | 3.67e-05 | 20 |
hsa0541714 | Liver | NAFLD | Lipid and atherosclerosis | 42/1043 | 215/8465 | 1.46e-03 | 1.71e-02 | 1.38e-02 | 42 |
hsa0497911 | Liver | NAFLD | Cholesterol metabolism | 20/1043 | 51/8465 | 9.73e-07 | 4.56e-05 | 3.67e-05 | 20 |
hsa0541715 | Liver | NAFLD | Lipid and atherosclerosis | 42/1043 | 215/8465 | 1.46e-03 | 1.71e-02 | 1.38e-02 | 42 |
hsa049792 | Liver | Cirrhotic | Cholesterol metabolism | 30/2530 | 51/8465 | 1.59e-05 | 1.39e-04 | 8.60e-05 | 30 |
hsa0541722 | Liver | Cirrhotic | Lipid and atherosclerosis | 80/2530 | 215/8465 | 1.18e-02 | 3.81e-02 | 2.35e-02 | 80 |
hsa049793 | Liver | Cirrhotic | Cholesterol metabolism | 30/2530 | 51/8465 | 1.59e-05 | 1.39e-04 | 8.60e-05 | 30 |
hsa0541732 | Liver | Cirrhotic | Lipid and atherosclerosis | 80/2530 | 215/8465 | 1.18e-02 | 3.81e-02 | 2.35e-02 | 80 |
hsa049794 | Liver | HCC | Cholesterol metabolism | 41/4020 | 51/8465 | 1.33e-06 | 1.35e-05 | 7.49e-06 | 41 |
hsa049795 | Liver | HCC | Cholesterol metabolism | 41/4020 | 51/8465 | 1.33e-06 | 1.35e-05 | 7.49e-06 | 41 |
hsa0541712 | Stomach | GC | Lipid and atherosclerosis | 40/708 | 215/8465 | 1.01e-06 | 1.80e-05 | 1.27e-05 | 40 |
hsa04975 | Stomach | GC | Fat digestion and absorption | 14/708 | 43/8465 | 5.71e-06 | 8.30e-05 | 5.84e-05 | 14 |
hsa0541713 | Stomach | GC | Lipid and atherosclerosis | 40/708 | 215/8465 | 1.01e-06 | 1.80e-05 | 1.27e-05 | 40 |
hsa049751 | Stomach | GC | Fat digestion and absorption | 14/708 | 43/8465 | 5.71e-06 | 8.30e-05 | 5.84e-05 | 14 |
hsa0541710 | Stomach | SIM | Lipid and atherosclerosis | 34/465 | 215/8465 | 1.80e-08 | 4.20e-07 | 3.37e-07 | 34 |
hsa049752 | Stomach | SIM | Fat digestion and absorption | 12/465 | 43/8465 | 2.11e-06 | 3.05e-05 | 2.45e-05 | 12 |
hsa04979 | Stomach | SIM | Cholesterol metabolism | 8/465 | 51/8465 | 6.17e-03 | 3.83e-02 | 3.08e-02 | 8 |
hsa0541711 | Stomach | SIM | Lipid and atherosclerosis | 34/465 | 215/8465 | 1.80e-08 | 4.20e-07 | 3.37e-07 | 34 |
hsa049753 | Stomach | SIM | Fat digestion and absorption | 12/465 | 43/8465 | 2.11e-06 | 3.05e-05 | 2.45e-05 | 12 |
hsa049791 | Stomach | SIM | Cholesterol metabolism | 8/465 | 51/8465 | 6.17e-03 | 3.83e-02 | 3.08e-02 | 8 |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
APOB | SNV | Missense_Mutation | novel | c.10465N>C | p.Tyr3489His | p.Y3489H | P04114 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-86-8073-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
APOB | SNV | Missense_Mutation | c.9758N>C | p.Val3253Ala | p.V3253A | P04114 | protein_coding | deleterious(0) | benign(0.209) | TCGA-86-8073-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
APOB | SNV | Missense_Mutation | c.6519N>C | p.Gln2173His | p.Q2173H | P04114 | protein_coding | deleterious(0) | probably_damaging(0.955) | TCGA-86-8074-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
APOB | SNV | Missense_Mutation | c.7348N>G | p.Leu2450Val | p.L2450V | P04114 | protein_coding | tolerated(0.11) | benign(0.045) | TCGA-86-8358-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
APOB | SNV | Missense_Mutation | novel | c.4220C>T | p.Ser1407Phe | p.S1407F | P04114 | protein_coding | tolerated(0.06) | probably_damaging(0.976) | TCGA-86-8673-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
APOB | SNV | Missense_Mutation | c.4636N>C | p.Ser1546Pro | p.S1546P | P04114 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-91-6848-01 | Lung | lung adenocarcinoma | Male | <65 | III/IV | Chemotherapy | cisplatin | CR | |
APOB | SNV | Missense_Mutation | c.8602G>C | p.Glu2868Gln | p.E2868Q | P04114 | protein_coding | deleterious(0.01) | possibly_damaging(0.854) | TCGA-91-A4BC-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
APOB | SNV | Missense_Mutation | novel | c.11989N>C | p.Ile3997Leu | p.I3997L | P04114 | protein_coding | tolerated(0.98) | benign(0) | TCGA-95-7039-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
APOB | SNV | Missense_Mutation | c.11173N>T | p.Val3725Phe | p.V3725F | P04114 | protein_coding | deleterious(0.02) | possibly_damaging(0.782) | TCGA-95-7039-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
APOB | SNV | Missense_Mutation | c.5282N>T | p.Gly1761Val | p.G1761V | P04114 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-95-7039-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
338 | APOB | DRUGGABLE GENOME, CLINICALLY ACTIONABLE | ETHANOL | ALCOHOL | 8576634 | |
338 | APOB | DRUGGABLE GENOME, CLINICALLY ACTIONABLE | LOVASTATIN | LOVASTATIN | 2351867,7662319,1588827 | |
338 | APOB | DRUGGABLE GENOME, CLINICALLY ACTIONABLE | LIGNAN | 15671223 | ||
338 | APOB | DRUGGABLE GENOME, CLINICALLY ACTIONABLE | TKM-APOB | |||
338 | APOB | DRUGGABLE GENOME, CLINICALLY ACTIONABLE | QUERCETIN | QUERCETIN | 16149735 | |
338 | APOB | DRUGGABLE GENOME, CLINICALLY ACTIONABLE | lomitapide | LOMITAPIDE | ||
338 | APOB | DRUGGABLE GENOME, CLINICALLY ACTIONABLE | EPIGALLOCATECHIN GALLATE | 11936850 | ||
338 | APOB | DRUGGABLE GENOME, CLINICALLY ACTIONABLE | PRAVASTATIN | PRAVASTATIN | 8312689 | |
338 | APOB | DRUGGABLE GENOME, CLINICALLY ACTIONABLE | warfarin | WARFARIN | ||
338 | APOB | DRUGGABLE GENOME, CLINICALLY ACTIONABLE | DEXAMETHASONE | DEXAMETHASONE | 7670964 |
Page: 1 2 3 |