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Gene: ZWINT |
Gene summary for ZWINT |
Gene summary. |
Gene information | Species | Human | Gene symbol | ZWINT | Gene ID | 11130 |
Gene name | ZW10 interacting kinetochore protein | |
Gene Alias | HZwint-1 | |
Cytomap | 10q21.1 | |
Gene Type | protein-coding | GO ID | GO:0000070 | UniProtAcc | O95229 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
11130 | ZWINT | LZE5T | Human | Esophagus | ESCC | 1.57e-02 | 3.52e-01 | 0.0514 |
11130 | ZWINT | LZE7T | Human | Esophagus | ESCC | 1.02e-03 | 2.73e-01 | 0.0667 |
11130 | ZWINT | LZE21T | Human | Esophagus | ESCC | 1.16e-05 | 2.66e-01 | 0.0655 |
11130 | ZWINT | LZE6T | Human | Esophagus | ESCC | 5.35e-04 | 2.56e-01 | 0.0845 |
11130 | ZWINT | P1T-E | Human | Esophagus | ESCC | 4.62e-03 | 2.49e-01 | 0.0875 |
11130 | ZWINT | P2T-E | Human | Esophagus | ESCC | 3.73e-18 | 5.64e-01 | 0.1177 |
11130 | ZWINT | P4T-E | Human | Esophagus | ESCC | 4.13e-17 | 4.16e-01 | 0.1323 |
11130 | ZWINT | P5T-E | Human | Esophagus | ESCC | 1.81e-22 | 6.06e-01 | 0.1327 |
11130 | ZWINT | P8T-E | Human | Esophagus | ESCC | 7.33e-10 | 4.32e-01 | 0.0889 |
11130 | ZWINT | P9T-E | Human | Esophagus | ESCC | 4.01e-04 | 1.78e-01 | 0.1131 |
11130 | ZWINT | P10T-E | Human | Esophagus | ESCC | 1.14e-05 | 2.74e-01 | 0.116 |
11130 | ZWINT | P11T-E | Human | Esophagus | ESCC | 9.07e-04 | 2.70e-01 | 0.1426 |
11130 | ZWINT | P15T-E | Human | Esophagus | ESCC | 5.37e-05 | 2.09e-01 | 0.1149 |
11130 | ZWINT | P16T-E | Human | Esophagus | ESCC | 7.38e-11 | 4.36e-01 | 0.1153 |
11130 | ZWINT | P17T-E | Human | Esophagus | ESCC | 2.60e-06 | 3.04e-01 | 0.1278 |
11130 | ZWINT | P21T-E | Human | Esophagus | ESCC | 6.36e-12 | 5.68e-01 | 0.1617 |
11130 | ZWINT | P24T-E | Human | Esophagus | ESCC | 4.42e-13 | 3.16e-01 | 0.1287 |
11130 | ZWINT | P26T-E | Human | Esophagus | ESCC | 6.70e-08 | 4.08e-01 | 0.1276 |
11130 | ZWINT | P27T-E | Human | Esophagus | ESCC | 1.34e-11 | 3.80e-01 | 0.1055 |
11130 | ZWINT | P28T-E | Human | Esophagus | ESCC | 3.08e-07 | 2.17e-01 | 0.1149 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:014001414 | Esophagus | ESCC | mitotic nuclear division | 218/8552 | 287/18723 | 6.17e-26 | 1.78e-23 | 218 |
GO:000007011 | Esophagus | ESCC | mitotic sister chromatid segregation | 138/8552 | 168/18723 | 1.37e-22 | 2.63e-20 | 138 |
GO:00008194 | Esophagus | ESCC | sister chromatid segregation | 157/8552 | 202/18723 | 8.41e-21 | 1.33e-18 | 157 |
GO:003304416 | Esophagus | ESCC | regulation of chromosome organization | 145/8552 | 187/18723 | 3.80e-19 | 4.31e-17 | 145 |
GO:000705911 | Esophagus | ESCC | chromosome segregation | 238/8552 | 346/18723 | 1.72e-18 | 1.82e-16 | 238 |
GO:004477216 | Esophagus | ESCC | mitotic cell cycle phase transition | 281/8552 | 424/18723 | 4.63e-18 | 4.45e-16 | 281 |
GO:000734615 | Esophagus | ESCC | regulation of mitotic cell cycle | 293/8552 | 457/18723 | 8.00e-16 | 5.64e-14 | 293 |
GO:00482853 | Esophagus | ESCC | organelle fission | 301/8552 | 488/18723 | 4.64e-13 | 2.12e-11 | 301 |
GO:00988133 | Esophagus | ESCC | nuclear chromosome segregation | 187/8552 | 281/18723 | 1.00e-12 | 4.36e-11 | 187 |
GO:00002802 | Esophagus | ESCC | nuclear division | 270/8552 | 439/18723 | 1.17e-11 | 4.24e-10 | 270 |
GO:190198713 | Esophagus | ESCC | regulation of cell cycle phase transition | 242/8552 | 390/18723 | 3.86e-11 | 1.26e-09 | 242 |
GO:190199013 | Esophagus | ESCC | regulation of mitotic cell cycle phase transition | 191/8552 | 299/18723 | 1.35e-10 | 3.94e-09 | 191 |
GO:00457865 | Esophagus | ESCC | negative regulation of cell cycle | 236/8552 | 385/18723 | 3.62e-10 | 9.93e-09 | 236 |
GO:00000754 | Esophagus | ESCC | cell cycle checkpoint | 117/8552 | 169/18723 | 4.47e-10 | 1.17e-08 | 117 |
GO:0010639110 | Esophagus | ESCC | negative regulation of organelle organization | 215/8552 | 348/18723 | 8.20e-10 | 2.01e-08 | 215 |
GO:00070934 | Esophagus | ESCC | mitotic cell cycle checkpoint | 90/8552 | 129/18723 | 2.49e-08 | 4.69e-07 | 90 |
GO:00519833 | Esophagus | ESCC | regulation of chromosome segregation | 67/8552 | 91/18723 | 5.42e-08 | 9.66e-07 | 67 |
GO:00070883 | Esophagus | ESCC | regulation of mitotic nuclear division | 78/8552 | 110/18723 | 6.96e-08 | 1.21e-06 | 78 |
GO:00070912 | Esophagus | ESCC | metaphase/anaphase transition of mitotic cell cycle | 49/8552 | 62/18723 | 7.65e-08 | 1.33e-06 | 49 |
GO:00513062 | Esophagus | ESCC | mitotic sister chromatid separation | 52/8552 | 67/18723 | 9.14e-08 | 1.52e-06 | 52 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZWINT | SNV | Missense_Mutation | novel | c.6N>T | p.Glu2Asp | p.E2D | O95229 | protein_coding | tolerated_low_confidence(0.17) | benign(0.297) | TCGA-85-8664-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | PD |
ZWINT | SNV | Missense_Mutation | novel | c.42G>T | p.Glu14Asp | p.E14D | O95229 | protein_coding | deleterious(0.02) | possibly_damaging(0.537) | TCGA-92-8063-01 | Lung | lung squamous cell carcinoma | Male | <65 | III/IV | Chemotherapy | taxol | SD |
ZWINT | SNV | Missense_Mutation | novel | c.56N>A | p.Val19Glu | p.V19E | O95229 | protein_coding | deleterious(0) | possibly_damaging(0.55) | TCGA-NC-A5HT-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Chemotherapy | carboplatin | PR |
ZWINT | SNV | Missense_Mutation | novel | c.22N>A | p.Ala8Thr | p.A8T | O95229 | protein_coding | tolerated(0.41) | benign(0.007) | TCGA-BA-5555-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
ZWINT | SNV | Missense_Mutation | novel | c.615N>C | p.Lys205Asn | p.K205N | O95229 | protein_coding | deleterious(0.01) | benign(0.276) | TCGA-CV-7089-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ZWINT | SNV | Missense_Mutation | novel | c.624G>T | p.Arg208Ser | p.R208S | O95229 | protein_coding | deleterious(0.02) | possibly_damaging(0.638) | TCGA-KC-A4BV-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
ZWINT | SNV | Missense_Mutation | novel | c.222N>T | p.Lys74Asn | p.K74N | O95229 | protein_coding | deleterious(0.03) | benign(0.027) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
ZWINT | SNV | Missense_Mutation | c.199N>A | p.Leu67Met | p.L67M | O95229 | protein_coding | deleterious(0.03) | possibly_damaging(0.489) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZWINT | SNV | Missense_Mutation | c.141N>C | p.Gln47His | p.Q47H | O95229 | protein_coding | deleterious(0.04) | benign(0.277) | TCGA-BR-7958-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
ZWINT | SNV | Missense_Mutation | c.574C>T | p.Leu192Phe | p.L192F | O95229 | protein_coding | deleterious(0.01) | possibly_damaging(0.892) | TCGA-BR-8059-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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