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Gene: ZNF750 |
Gene summary for ZNF750 |
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Gene information | Species | Human | Gene symbol | ZNF750 | Gene ID | 79755 |
Gene name | zinc finger protein 750 | |
Gene Alias | ZFP750 | |
Cytomap | 17q25.3 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | Q32MQ0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79755 | ZNF750 | LZE4T | Human | Esophagus | ESCC | 1.89e-07 | 2.96e-01 | 0.0811 |
79755 | ZNF750 | LZE7T | Human | Esophagus | ESCC | 2.24e-02 | 1.56e-01 | 0.0667 |
79755 | ZNF750 | LZE20T | Human | Esophagus | ESCC | 1.09e-06 | 3.31e-01 | 0.0662 |
79755 | ZNF750 | LZE22T | Human | Esophagus | ESCC | 1.41e-03 | 6.12e-01 | 0.068 |
79755 | ZNF750 | LZE24T | Human | Esophagus | ESCC | 2.77e-10 | 6.64e-01 | 0.0596 |
79755 | ZNF750 | LZE21T | Human | Esophagus | ESCC | 3.98e-08 | 1.07e+00 | 0.0655 |
79755 | ZNF750 | P1T-E | Human | Esophagus | ESCC | 2.11e-09 | 5.31e-01 | 0.0875 |
79755 | ZNF750 | P2T-E | Human | Esophagus | ESCC | 2.05e-07 | 2.77e-01 | 0.1177 |
79755 | ZNF750 | P4T-E | Human | Esophagus | ESCC | 2.09e-08 | 3.06e-01 | 0.1323 |
79755 | ZNF750 | P5T-E | Human | Esophagus | ESCC | 1.80e-15 | 4.04e-01 | 0.1327 |
79755 | ZNF750 | P8T-E | Human | Esophagus | ESCC | 2.37e-08 | 2.23e-01 | 0.0889 |
79755 | ZNF750 | P9T-E | Human | Esophagus | ESCC | 8.33e-16 | 5.72e-01 | 0.1131 |
79755 | ZNF750 | P12T-E | Human | Esophagus | ESCC | 2.03e-29 | 1.14e+00 | 0.1122 |
79755 | ZNF750 | P15T-E | Human | Esophagus | ESCC | 6.59e-21 | 9.67e-01 | 0.1149 |
79755 | ZNF750 | P20T-E | Human | Esophagus | ESCC | 7.04e-14 | 6.18e-01 | 0.1124 |
79755 | ZNF750 | P23T-E | Human | Esophagus | ESCC | 1.29e-31 | 1.25e+00 | 0.108 |
79755 | ZNF750 | P24T-E | Human | Esophagus | ESCC | 1.30e-23 | 1.08e+00 | 0.1287 |
79755 | ZNF750 | P26T-E | Human | Esophagus | ESCC | 2.22e-16 | 5.69e-01 | 0.1276 |
79755 | ZNF750 | P27T-E | Human | Esophagus | ESCC | 1.57e-18 | 6.37e-01 | 0.1055 |
79755 | ZNF750 | P28T-E | Human | Esophagus | ESCC | 2.04e-71 | 1.90e+00 | 0.1149 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000854410 | Esophagus | ESCC | epidermis development | 193/8552 | 324/18723 | 2.87e-07 | 4.19e-06 | 193 |
GO:00018378 | Esophagus | ESCC | epithelial to mesenchymal transition | 95/8552 | 157/18723 | 1.25e-04 | 8.56e-04 | 95 |
GO:00487628 | Esophagus | ESCC | mesenchymal cell differentiation | 133/8552 | 236/18723 | 5.94e-04 | 3.22e-03 | 133 |
GO:00107174 | Esophagus | ESCC | regulation of epithelial to mesenchymal transition | 61/8552 | 99/18723 | 1.01e-03 | 5.09e-03 | 61 |
GO:00604856 | Esophagus | ESCC | mesenchyme development | 156/8552 | 291/18723 | 3.76e-03 | 1.53e-02 | 156 |
GO:00085449 | Oral cavity | OSCC | epidermis development | 171/7305 | 324/18723 | 2.89e-07 | 4.43e-06 | 171 |
GO:00018377 | Oral cavity | OSCC | epithelial to mesenchymal transition | 82/7305 | 157/18723 | 5.09e-04 | 2.98e-03 | 82 |
GO:00107173 | Oral cavity | OSCC | regulation of epithelial to mesenchymal transition | 54/7305 | 99/18723 | 1.21e-03 | 6.10e-03 | 54 |
GO:00487627 | Oral cavity | OSCC | mesenchymal cell differentiation | 109/7305 | 236/18723 | 1.43e-02 | 4.69e-02 | 109 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF750 | SNV | Missense_Mutation | c.2114C>T | p.Ala705Val | p.A705V | Q32MQ0 | protein_coding | tolerated(0.73) | benign(0.011) | TCGA-D1-A15X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ZNF750 | SNV | Missense_Mutation | c.1631C>T | p.Ser544Leu | p.S544L | Q32MQ0 | protein_coding | tolerated(0.78) | benign(0) | TCGA-D1-A17U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD | |
ZNF750 | SNV | Missense_Mutation | novel | c.1996N>T | p.Asp666Tyr | p.D666Y | Q32MQ0 | protein_coding | deleterious(0.01) | possibly_damaging(0.799) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
ZNF750 | SNV | Missense_Mutation | novel | c.1921N>A | p.Leu641Met | p.L641M | Q32MQ0 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF750 | SNV | Missense_Mutation | novel | c.217C>T | p.Pro73Ser | p.P73S | Q32MQ0 | protein_coding | tolerated(0.12) | benign(0.22) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF750 | SNV | Missense_Mutation | rs148969250 | c.299N>T | p.Ser100Leu | p.S100L | Q32MQ0 | protein_coding | tolerated(0.19) | benign(0.003) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ZNF750 | SNV | Missense_Mutation | rs34566230 | c.907N>A | p.Asp303Asn | p.D303N | Q32MQ0 | protein_coding | tolerated(0.14) | benign(0.376) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
ZNF750 | SNV | Missense_Mutation | novel | c.512N>G | p.Lys171Arg | p.K171R | Q32MQ0 | protein_coding | tolerated(0.1) | benign(0.181) | TCGA-FI-A2F4-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF750 | SNV | Missense_Mutation | novel | c.1960N>A | p.Gly654Arg | p.G654R | Q32MQ0 | protein_coding | tolerated(0.13) | benign(0.164) | TCGA-SL-A6JA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF750 | insertion | Frame_Shift_Ins | novel | c.671_672insGGCCACACTCTCACGTGAAA | p.Thr225AlafsTer148 | p.T225Afs*148 | Q32MQ0 | protein_coding | TCGA-B5-A0K2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Hormone Therapy | megace | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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