TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
ZNF680 | MSC | Breast | ADJ | MIR762HG,SETDB2,EEF2K, etc. | 9.25e-03 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Breast/Str/TF_ADJ/regulons_activity_in_dotplot.png) |
ZNF680 | CAF | Breast | DCIS | MIR762HG,SETDB2,EEF2K, etc. | 4.69e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Breast/Str/TF_DCIS/regulons_activity_in_dotplot.png) |
ZNF680 | PVA | Breast | DCIS | MIR762HG,SETDB2,EEF2K, etc. | 1.63e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Breast/Str/TF_DCIS/regulons_activity_in_dotplot.png) |
ZNF680 | MSC | Breast | Healthy | MIR762HG,SETDB2,EEF2K, etc. | 3.13e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Breast/Str/TF_Healthy/regulons_activity_in_dotplot.png) |
ZNF680 | CAF | Breast | IDC | MIR762HG,SETDB2,EEF2K, etc. | 4.68e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Breast/Str/TF_IDC/regulons_activity_in_dotplot.png) |
ZNF680 | LYMEND | Breast | Precancer | MIR762HG,SETDB2,EEF2K, etc. | 1.11e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Breast/Str/TF_Precancer/regulons_activity_in_dotplot.png) |
ZNF680 | PIL | Skin | AK | HIST1H2AC,HIST1H2BJ,HIST1H2BK, etc. | 1.86e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Skin/Str/TF_AK/regulons_activity_in_dotplot.png) |
ZNF680 | KER | Skin | AK | HIST1H2AC,HIST1H2BJ,HIST1H2BK, etc. | -2.22e-16 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Skin/Str/TF_AK/regulons_activity_in_dotplot.png) |
ZNF680 | PIL | Skin | SCCIS | HIST1H2AC,HIST1H2BJ,HIST1H2BK, etc. | 2.50e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Skin/Str/TF_SCCIS/regulons_activity_in_dotplot.png) |
ZNF680 | ECC | Skin | SCCIS | HIST1H2AC,HIST1H2BJ,HIST1H2BK, etc. | 1.26e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Skin/Str/TF_SCCIS/regulons_activity_in_dotplot.png) |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF680 | SNV | Missense_Mutation | | c.1277N>T | p.Arg426Ile | p.R426I | Q8NEM1 | protein_coding | tolerated(0.55) | possibly_damaging(0.773) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF680 | SNV | Missense_Mutation | | c.941N>T | p.Arg314Ile | p.R314I | Q8NEM1 | protein_coding | tolerated(0.56) | benign(0.003) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF680 | SNV | Missense_Mutation | | c.766C>A | p.His256Asn | p.H256N | Q8NEM1 | protein_coding | deleterious(0.01) | probably_damaging(0.996) | TCGA-D1-A163-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | taxol | SD |
ZNF680 | SNV | Missense_Mutation | | c.440N>T | p.Arg147Ile | p.R147I | Q8NEM1 | protein_coding | tolerated(0.15) | benign(0) | TCGA-D1-A16X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF680 | SNV | Missense_Mutation | | c.1193N>A | p.Arg398Lys | p.R398K | Q8NEM1 | protein_coding | tolerated(0.43) | benign(0.006) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF680 | SNV | Missense_Mutation | rs376623323 | c.1502N>A | p.Arg501Gln | p.R501Q | Q8NEM1 | protein_coding | tolerated(1) | benign(0.005) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF680 | SNV | Missense_Mutation | rs753118626 | c.304N>T | p.Asp102Tyr | p.D102Y | Q8NEM1 | protein_coding | deleterious(0.05) | probably_damaging(0.995) | TCGA-EO-A22X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response |
ZNF680 | SNV | Missense_Mutation | novel | c.1445N>T | p.Arg482Ile | p.R482I | Q8NEM1 | protein_coding | tolerated(0.41) | benign(0) | TCGA-EO-A3AY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
ZNF680 | SNV | Missense_Mutation | novel | c.66N>A | p.Phe22Leu | p.F22L | Q8NEM1 | protein_coding | deleterious(0.01) | probably_damaging(0.95) | TCGA-EO-A3AY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
ZNF680 | SNV | Missense_Mutation | novel | c.1388N>C | p.Lys463Thr | p.K463T | Q8NEM1 | protein_coding | deleterious(0.02) | probably_damaging(0.999) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |