Tissue | Expression Dynamics | Abbreviation |
Cervix | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Cervix/ZNF654_pca_on_diff_genes.png) | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions |
N_HPV: HPV-infected normal cervix |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/ZNF654_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/ZNF654_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Lung | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Lung/ZNF654_pca_on_diff_genes.png) | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
ZNF654 | CD8TEREX | Breast | ADJ | LPAR5,EBPL,NBR1, etc. | 2.53e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Breast/Str/TF_ADJ/regulons_activity_in_dotplot.png) |
ZNF654 | CD8TEX | Breast | ADJ | LPAR5,EBPL,NBR1, etc. | 4.12e-03 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Breast/Str/TF_ADJ/regulons_activity_in_dotplot.png) |
ZNF654 | TREG | Breast | Precancer | LPAR5,EBPL,NBR1, etc. | 2.58e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Breast/Str/TF_Precancer/regulons_activity_in_dotplot.png) |
ZNF654 | M1MAC | Breast | Precancer | LPAR5,EBPL,NBR1, etc. | 2.23e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Breast/Str/TF_Precancer/regulons_activity_in_dotplot.png) |
ZNF654 | NEUT | Cervix | ADJ | GRB10,CGGBP1,DUSP10, etc. | 1.14e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Cervix/Str/TF_ADJ/regulons_activity_in_dotplot.png) |
ZNF654 | BMEM | Cervix | CC | GRB10,CGGBP1,DUSP10, etc. | 5.78e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Cervix/Str/TF_CC/regulons_activity_in_dotplot.png) |
ZNF654 | GC | Cervix | CC | GRB10,CGGBP1,DUSP10, etc. | 7.83e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Cervix/Str/TF_CC/regulons_activity_in_dotplot.png) |
ZNF654 | PLA | Cervix | Healthy | GRB10,CGGBP1,DUSP10, etc. | 8.64e-03 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Cervix/Str/TF_Healthy/regulons_activity_in_dotplot.png) |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF654 | SNV | Missense_Mutation | novel | c.557A>C | p.Lys186Thr | p.K186T | | protein_coding | tolerated(0.11) | benign(0.254) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
ZNF654 | SNV | Missense_Mutation | | c.856N>A | p.Ala286Thr | p.A286T | Q8IZM8 | protein_coding | tolerated(0.11) | benign(0.03) | TCGA-DD-A4NO-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
ZNF654 | SNV | Missense_Mutation | | c.586G>A | p.Glu196Lys | p.E196K | Q8IZM8 | protein_coding | tolerated(0.16) | benign(0.012) | TCGA-55-6972-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ZNF654 | SNV | Missense_Mutation | | c.1711N>G | p.Leu571Val | p.L571V | Q8IZM8 | protein_coding | deleterious(0) | probably_damaging(0.943) | TCGA-18-3411-01 | Lung | lung squamous cell carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ZNF654 | SNV | Missense_Mutation | | c.894N>T | p.Gln298His | p.Q298H | Q8IZM8 | protein_coding | deleterious(0) | probably_damaging(0.974) | TCGA-22-5492-01 | Lung | lung squamous cell carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
ZNF654 | SNV | Missense_Mutation | novel | c.1292N>T | p.Asn431Ile | p.N431I | Q8IZM8 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-63-7023-01 | Lung | lung squamous cell carcinoma | Male | Unknown | I/II | Unspecific | Vinorelbine Tartrate | SD |
ZNF654 | SNV | Missense_Mutation | rs199884128 | c.1501N>A | p.Val501Ile | p.V501I | Q8IZM8 | protein_coding | tolerated(0.32) | benign(0.106) | TCGA-85-8664-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | PD |
ZNF654 | SNV | Missense_Mutation | novel | c.565N>C | p.Asp189His | p.D189H | Q8IZM8 | protein_coding | deleterious(0.01) | benign(0.445) | TCGA-CN-5367-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
ZNF654 | SNV | Missense_Mutation | novel | c.135N>C | p.Lys45Asn | p.K45N | Q8IZM8 | protein_coding | deleterious(0) | possibly_damaging(0.631) | TCGA-CQ-7071-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
ZNF654 | SNV | Missense_Mutation | novel | c.1301G>C | p.Ser434Thr | p.S434T | Q8IZM8 | protein_coding | deleterious(0.03) | benign(0.001) | TCGA-CV-6941-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |