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Gene: ZNF639 |
Gene summary for ZNF639 |
Gene summary. |
Gene information | Species | Human | Gene symbol | ZNF639 | Gene ID | 51193 |
Gene name | zinc finger protein 639 | |
Gene Alias | ANC-2H01 | |
Cytomap | 3q26.33 | |
Gene Type | protein-coding | GO ID | GO:0001558 | UniProtAcc | Q9UID6 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51193 | ZNF639 | LZE4T | Human | Esophagus | ESCC | 4.12e-05 | 1.91e-01 | 0.0811 |
51193 | ZNF639 | LZE24T | Human | Esophagus | ESCC | 1.75e-09 | 3.21e-01 | 0.0596 |
51193 | ZNF639 | P1T-E | Human | Esophagus | ESCC | 2.25e-06 | 3.61e-01 | 0.0875 |
51193 | ZNF639 | P2T-E | Human | Esophagus | ESCC | 9.35e-49 | 1.01e+00 | 0.1177 |
51193 | ZNF639 | P4T-E | Human | Esophagus | ESCC | 1.42e-34 | 8.92e-01 | 0.1323 |
51193 | ZNF639 | P5T-E | Human | Esophagus | ESCC | 5.67e-35 | 7.75e-01 | 0.1327 |
51193 | ZNF639 | P8T-E | Human | Esophagus | ESCC | 4.67e-26 | 3.74e-01 | 0.0889 |
51193 | ZNF639 | P9T-E | Human | Esophagus | ESCC | 5.87e-11 | 3.32e-01 | 0.1131 |
51193 | ZNF639 | P10T-E | Human | Esophagus | ESCC | 6.30e-30 | 4.66e-01 | 0.116 |
51193 | ZNF639 | P11T-E | Human | Esophagus | ESCC | 6.82e-08 | 4.32e-01 | 0.1426 |
51193 | ZNF639 | P12T-E | Human | Esophagus | ESCC | 1.93e-23 | 4.97e-01 | 0.1122 |
51193 | ZNF639 | P15T-E | Human | Esophagus | ESCC | 1.03e-19 | 4.91e-01 | 0.1149 |
51193 | ZNF639 | P16T-E | Human | Esophagus | ESCC | 2.66e-25 | 3.36e-01 | 0.1153 |
51193 | ZNF639 | P20T-E | Human | Esophagus | ESCC | 1.81e-10 | 2.21e-01 | 0.1124 |
51193 | ZNF639 | P21T-E | Human | Esophagus | ESCC | 2.99e-15 | 2.71e-01 | 0.1617 |
51193 | ZNF639 | P22T-E | Human | Esophagus | ESCC | 1.45e-17 | 3.88e-01 | 0.1236 |
51193 | ZNF639 | P23T-E | Human | Esophagus | ESCC | 5.20e-18 | 5.97e-01 | 0.108 |
51193 | ZNF639 | P24T-E | Human | Esophagus | ESCC | 1.87e-16 | 1.87e-01 | 0.1287 |
51193 | ZNF639 | P26T-E | Human | Esophagus | ESCC | 1.63e-78 | 1.39e+00 | 0.1276 |
51193 | ZNF639 | P27T-E | Human | Esophagus | ESCC | 5.78e-27 | 6.30e-01 | 0.1055 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0016032111 | Esophagus | ESCC | viral process | 301/8552 | 415/18723 | 3.34e-29 | 1.32e-26 | 301 |
GO:0019058111 | Esophagus | ESCC | viral life cycle | 226/8552 | 317/18723 | 1.17e-20 | 1.76e-18 | 226 |
GO:001908017 | Esophagus | ESCC | viral gene expression | 80/8552 | 94/18723 | 2.04e-15 | 1.28e-13 | 80 |
GO:0016049110 | Esophagus | ESCC | cell growth | 289/8552 | 482/18723 | 1.29e-10 | 3.77e-09 | 289 |
GO:0044403111 | Esophagus | ESCC | biological process involved in symbiotic interaction | 186/8552 | 290/18723 | 1.43e-10 | 4.16e-09 | 186 |
GO:0051701111 | Esophagus | ESCC | biological process involved in interaction with host | 135/8552 | 203/18723 | 1.49e-09 | 3.49e-08 | 135 |
GO:000155819 | Esophagus | ESCC | regulation of cell growth | 248/8552 | 414/18723 | 2.97e-09 | 6.45e-08 | 248 |
GO:0052126111 | Esophagus | ESCC | movement in host environment | 117/8552 | 175/18723 | 1.14e-08 | 2.26e-07 | 117 |
GO:001908312 | Esophagus | ESCC | viral transcription | 41/8552 | 50/18723 | 1.35e-07 | 2.17e-06 | 41 |
GO:0044409111 | Esophagus | ESCC | entry into host | 96/8552 | 151/18723 | 6.73e-06 | 6.84e-05 | 96 |
GO:005185115 | Esophagus | ESCC | modulation by host of symbiont process | 43/8552 | 60/18723 | 4.00e-05 | 3.22e-04 | 43 |
GO:004671827 | Esophagus | ESCC | viral entry into host cell | 89/8552 | 144/18723 | 6.84e-05 | 5.18e-04 | 89 |
GO:003030710 | Esophagus | ESCC | positive regulation of cell growth | 100/8552 | 166/18723 | 1.07e-04 | 7.55e-04 | 100 |
GO:005181714 | Esophagus | ESCC | modulation of process of other organism involved in symbiotic interaction | 54/8552 | 81/18723 | 1.09e-04 | 7.64e-04 | 54 |
GO:00439233 | Esophagus | ESCC | positive regulation by host of viral transcription | 14/8552 | 16/18723 | 6.78e-04 | 3.56e-03 | 14 |
GO:003582114 | Esophagus | ESCC | modulation of process of other organism | 64/8552 | 106/18723 | 1.61e-03 | 7.50e-03 | 64 |
GO:005170214 | Esophagus | ESCC | biological process involved in interaction with symbiont | 57/8552 | 94/18723 | 2.46e-03 | 1.07e-02 | 57 |
GO:00439224 | Esophagus | ESCC | negative regulation by host of viral transcription | 12/8552 | 14/18723 | 2.51e-03 | 1.08e-02 | 12 |
GO:004592717 | Esophagus | ESCC | positive regulation of growth | 137/8552 | 259/18723 | 1.13e-02 | 3.80e-02 | 137 |
GO:001603222 | Liver | HCC | viral process | 286/7958 | 415/18723 | 4.41e-28 | 1.86e-25 | 286 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
ZNF639 | BAS | Breast | DCIS | CCK,FAM84B,ZNF668, etc. | 1.17e-01 | |
ZNF639 | PERI | Lung | AAH | COPS4,PTPRD,HIST1H2BJ, etc. | 2.38e-01 |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF639 | SNV | Missense_Mutation | novel | c.462G>C | p.Glu154Asp | p.E154D | Q9UID6 | protein_coding | tolerated(0.06) | probably_damaging(0.956) | TCGA-56-A4BX-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | chemo | CR |
ZNF639 | SNV | Missense_Mutation | rs761271239 | c.886N>A | p.Val296Ile | p.V296I | Q9UID6 | protein_coding | tolerated(0.36) | benign(0.031) | TCGA-60-2703-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
ZNF639 | SNV | Missense_Mutation | c.1358A>G | p.Lys453Arg | p.K453R | Q9UID6 | protein_coding | tolerated(0.91) | benign(0) | TCGA-66-2787-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
ZNF639 | SNV | Missense_Mutation | c.350N>T | p.Pro117Leu | p.P117L | Q9UID6 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-66-2800-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
ZNF639 | SNV | Missense_Mutation | novel | c.343N>C | p.Asp115His | p.D115H | Q9UID6 | protein_coding | deleterious(0.04) | benign(0.299) | TCGA-85-7950-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ZNF639 | SNV | Missense_Mutation | novel | c.356N>T | p.Ser119Leu | p.S119L | Q9UID6 | protein_coding | tolerated(0.39) | benign(0.096) | TCGA-98-A53I-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | navelbine | SD |
ZNF639 | insertion | Frame_Shift_Ins | novel | c.169_169+1insATGATGATTCTGATACCGAGAC | p.Ser65Ter | p.S65* | Q9UID6 | protein_coding | TCGA-85-7843-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | ||
ZNF639 | SNV | Missense_Mutation | novel | c.1348N>G | p.Leu450Val | p.L450V | Q9UID6 | protein_coding | tolerated(0.14) | benign(0.112) | TCGA-BA-6871-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
ZNF639 | SNV | Missense_Mutation | novel | c.736N>G | p.Met246Val | p.M246V | Q9UID6 | protein_coding | tolerated(0.41) | benign(0) | TCGA-CN-6989-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | carboplatin | PD |
ZNF639 | SNV | Missense_Mutation | novel | c.1193C>G | p.Thr398Arg | p.T398R | Q9UID6 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-P3-A6T5-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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