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Gene: ZNF587 |
Gene summary for ZNF587 |
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Gene information | Species | Human | Gene symbol | ZNF587 | Gene ID | 84914 |
Gene name | zinc finger protein 587 | |
Gene Alias | ZF6 | |
Cytomap | 19q13.43 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q96SQ5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84914 | ZNF587 | HCC1_Meng | Human | Liver | HCC | 3.02e-23 | 6.84e-03 | 0.0246 |
84914 | ZNF587 | HCC2_Meng | Human | Liver | HCC | 1.82e-12 | 9.27e-02 | 0.0107 |
84914 | ZNF587 | HCC1 | Human | Liver | HCC | 5.77e-04 | 2.77e+00 | 0.5336 |
84914 | ZNF587 | HCC2 | Human | Liver | HCC | 2.54e-04 | 1.54e+00 | 0.5341 |
84914 | ZNF587 | HCC5 | Human | Liver | HCC | 2.16e-06 | 2.05e+00 | 0.4932 |
84914 | ZNF587 | S028 | Human | Liver | HCC | 3.21e-03 | 2.45e-01 | 0.2503 |
84914 | ZNF587 | male-WTA | Human | Thyroid | PTC | 8.59e-06 | 7.59e-02 | 0.1037 |
84914 | ZNF587 | PTC01 | Human | Thyroid | PTC | 1.44e-03 | 7.92e-02 | 0.1899 |
84914 | ZNF587 | PTC03 | Human | Thyroid | PTC | 1.79e-02 | 1.28e-01 | 0.1784 |
84914 | ZNF587 | PTC04 | Human | Thyroid | PTC | 5.69e-16 | 2.24e-01 | 0.1927 |
84914 | ZNF587 | PTC05 | Human | Thyroid | PTC | 1.99e-09 | 2.99e-01 | 0.2065 |
84914 | ZNF587 | PTC06 | Human | Thyroid | PTC | 2.51e-21 | 4.17e-01 | 0.2057 |
84914 | ZNF587 | PTC07 | Human | Thyroid | PTC | 4.27e-10 | 2.19e-01 | 0.2044 |
84914 | ZNF587 | ATC11 | Human | Thyroid | ATC | 7.49e-03 | 2.26e-01 | 0.3386 |
84914 | ZNF587 | ATC12 | Human | Thyroid | ATC | 1.11e-07 | 1.84e-01 | 0.34 |
84914 | ZNF587 | ATC13 | Human | Thyroid | ATC | 2.99e-14 | 3.44e-01 | 0.34 |
84914 | ZNF587 | ATC1 | Human | Thyroid | ATC | 4.70e-02 | 1.10e-01 | 0.2878 |
84914 | ZNF587 | ATC2 | Human | Thyroid | ATC | 2.02e-16 | 1.04e+00 | 0.34 |
84914 | ZNF587 | ATC3 | Human | Thyroid | ATC | 6.22e-03 | 1.84e-01 | 0.338 |
84914 | ZNF587 | ATC4 | Human | Thyroid | ATC | 8.48e-13 | 2.56e-01 | 0.34 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF587 | SNV | Missense_Mutation | novel | c.875N>A | p.Gly292Glu | p.G292E | Q96SQ5 | protein_coding | deleterious(0.04) | probably_damaging(0.987) | TCGA-B5-A1MX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD |
ZNF587 | SNV | Missense_Mutation | novel | c.170N>C | p.Trp57Ser | p.W57S | Q96SQ5 | protein_coding | deleterious(0.03) | benign(0.087) | TCGA-B5-A3F9-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF587 | SNV | Missense_Mutation | rs749002982 | c.541N>T | p.Pro181Ser | p.P181S | Q96SQ5 | protein_coding | tolerated(0.19) | benign(0.001) | TCGA-D1-A175-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
ZNF587 | SNV | Missense_Mutation | novel | c.1474N>C | p.Tyr492His | p.Y492H | Q96SQ5 | protein_coding | deleterious(0) | benign(0.399) | TCGA-D1-A175-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
ZNF587 | SNV | Missense_Mutation | novel | c.1100N>G | p.Phe367Cys | p.F367C | Q96SQ5 | protein_coding | deleterious(0) | possibly_damaging(0.449) | TCGA-EO-A22X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response |
ZNF587 | SNV | Missense_Mutation | c.1394N>T | p.Ala465Val | p.A465V | Q96SQ5 | protein_coding | tolerated(0.06) | benign(0) | TCGA-EO-A22X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response | |
ZNF587 | SNV | Missense_Mutation | rs200818331 | c.122N>A | p.Arg41His | p.R41H | Q96SQ5 | protein_coding | tolerated(0.99) | benign(0.001) | TCGA-EO-A3AZ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF587 | SNV | Missense_Mutation | rs755988325 | c.1084N>T | p.Arg362Cys | p.R362C | Q96SQ5 | protein_coding | tolerated(0.07) | benign(0.285) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ZNF587 | insertion | In_Frame_Ins | novel | c.449_450insTATTTGCAG | p.Lys150delinsAsnIleCysArg | p.K150delinsNICR | Q96SQ5 | protein_coding | TCGA-A5-A0R9-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
ZNF587 | insertion | Frame_Shift_Ins | novel | c.449_450insTATTT | p.Lys150AsnfsTer3 | p.K150Nfs*3 | Q96SQ5 | protein_coding | TCGA-BG-A0MG-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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