TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
ZNF557 | BN | Liver | Cirrhotic | LINC01138,TKT,CHST12, etc. | 1.09e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Liver/Str/TF_Cirrhotic/regulons_activity_in_dotplot.png) |
ZNF557 | MEGA | Lung | ADJ | TMEM86A,AC147067.1,FLT1, etc. | 3.35e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Lung/Str/TF_ADJ/regulons_activity_in_dotplot.png) |
ZNF557 | FIB | Lung | Healthy | TMEM86A,AC147067.1,FLT1, etc. | 4.45e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Lung/Str/TF_Healthy/regulons_activity_in_dotplot.png) |
ZNF557 | PVA | Lung | Healthy | TMEM86A,AC147067.1,FLT1, etc. | 1.08e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Lung/Str/TF_Healthy/regulons_activity_in_dotplot.png) |
ZNF557 | PVA | Lung | IAC | TMEM86A,AC147067.1,FLT1, etc. | 1.51e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Lung/Str/TF_IAC/regulons_activity_in_dotplot.png) |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF557 | SNV | Missense_Mutation | | c.325C>A | p.Leu109Ile | p.L109I | Q8N988 | protein_coding | tolerated(0.19) | benign(0.011) | TCGA-BS-A0UV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ZNF557 | SNV | Missense_Mutation | | c.325N>A | p.Leu109Ile | p.L109I | Q8N988 | protein_coding | tolerated(0.19) | benign(0.011) | TCGA-D1-A16X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF557 | SNV | Missense_Mutation | | c.208G>A | p.Asp70Asn | p.D70N | Q8N988 | protein_coding | tolerated(0.11) | benign(0.001) | TCGA-D1-A177-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
ZNF557 | SNV | Missense_Mutation | | c.614N>G | p.Glu205Gly | p.E205G | Q8N988 | protein_coding | deleterious(0) | possibly_damaging(0.824) | TCGA-D1-A17Q-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF557 | SNV | Missense_Mutation | | c.325N>T | p.Leu109Phe | p.L109F | Q8N988 | protein_coding | tolerated(0.22) | benign(0.111) | TCGA-DF-A2KV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF557 | SNV | Missense_Mutation | | c.1090A>G | p.Thr364Ala | p.T364A | Q8N988 | protein_coding | tolerated(1) | benign(0.04) | TCGA-DI-A0WH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF557 | SNV | Missense_Mutation | | c.325N>A | p.Leu109Ile | p.L109I | Q8N988 | protein_coding | tolerated(0.19) | benign(0.011) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF557 | SNV | Missense_Mutation | novel | c.683N>T | p.Arg228Ile | p.R228I | Q8N988 | protein_coding | deleterious(0) | possibly_damaging(0.871) | TCGA-E6-A1M0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
ZNF557 | SNV | Missense_Mutation | novel | c.1080N>A | p.Ser360Arg | p.S360R | Q8N988 | protein_coding | tolerated(0.43) | benign(0.005) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF557 | SNV | Missense_Mutation | novel | c.436N>A | p.His146Asn | p.H146N | Q8N988 | protein_coding | tolerated(0.06) | possibly_damaging(0.896) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |