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Gene: ZNF469 |
Gene summary for ZNF469 |
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Gene information | Species | Human | Gene symbol | ZNF469 | Gene ID | 84627 |
Gene name | zinc finger protein 469 | |
Gene Alias | BCS | |
Cytomap | 16q24.2 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | H3BS19 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84627 | ZNF469 | ATC11 | Human | Thyroid | ATC | 1.60e-07 | 8.53e-01 | 0.3386 |
84627 | ZNF469 | ATC12 | Human | Thyroid | ATC | 5.95e-07 | 2.48e-01 | 0.34 |
84627 | ZNF469 | ATC13 | Human | Thyroid | ATC | 4.70e-13 | 2.63e-01 | 0.34 |
84627 | ZNF469 | ATC3 | Human | Thyroid | ATC | 2.42e-14 | 9.16e-01 | 0.338 |
84627 | ZNF469 | ATC4 | Human | Thyroid | ATC | 3.55e-10 | 3.16e-01 | 0.34 |
84627 | ZNF469 | ATC5 | Human | Thyroid | ATC | 2.12e-13 | 2.82e-01 | 0.34 |
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Tissue | Expression Dynamics | Abbreviation |
Thyroid | ![]() | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF469 | SNV | Missense_Mutation | c.5768N>T | p.Ala1923Val | p.A1923V | Q96JG9 | protein_coding | deleterious(0.01) | probably_damaging(0.941) | TCGA-AY-6197-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
ZNF469 | SNV | Missense_Mutation | c.8974N>T | p.Pro2992Ser | p.P2992S | Q96JG9 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AY-6197-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
ZNF469 | SNV | Missense_Mutation | rs113957796 | c.4247N>T | p.Ala1416Val | p.A1416V | Q96JG9 | protein_coding | tolerated(0.25) | benign(0.395) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ZNF469 | SNV | Missense_Mutation | novel | c.5815C>A | p.Leu1939Ile | p.L1939I | Q96JG9 | protein_coding | tolerated(0.91) | benign(0.013) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
ZNF469 | SNV | Missense_Mutation | c.2734C>T | p.Arg912Cys | p.R912C | Q96JG9 | protein_coding | tolerated(0.19) | benign(0.003) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
ZNF469 | SNV | Missense_Mutation | c.10061N>T | p.Ala3354Val | p.A3354V | Q96JG9 | protein_coding | tolerated(0.37) | benign(0.018) | TCGA-CM-5861-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
ZNF469 | SNV | Missense_Mutation | rs369117913 | c.6613N>A | p.Val2205Ile | p.V2205I | Q96JG9 | protein_coding | tolerated(1) | benign(0.001) | TCGA-CM-6161-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF469 | SNV | Missense_Mutation | c.4510N>T | p.Arg1504Trp | p.R1504W | Q96JG9 | protein_coding | deleterious(0.02) | possibly_damaging(0.764) | TCGA-CM-6162-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | oxaliplatin | SD | |
ZNF469 | SNV | Missense_Mutation | c.9056N>G | p.Glu3019Gly | p.E3019G | Q96JG9 | protein_coding | tolerated(0.11) | benign(0.099) | TCGA-CM-6162-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | oxaliplatin | SD | |
ZNF469 | SNV | Missense_Mutation | rs865985076 | c.4762G>A | p.Val1588Met | p.V1588M | Q96JG9 | protein_coding | tolerated(0.29) | benign(0.003) | TCGA-D5-5539-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5-fu | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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