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Gene: ZNF462 |
Gene summary for ZNF462 |
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Gene information | Species | Human | Gene symbol | ZNF462 | Gene ID | 58499 |
Gene name | zinc finger protein 462 | |
Gene Alias | WSKA | |
Cytomap | 9q31.2 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q63HJ5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
58499 | ZNF462 | CA_HPV_1 | Human | Cervix | CC | 1.88e-05 | -1.73e-01 | 0.0264 |
58499 | ZNF462 | CCI_3 | Human | Cervix | CC | 3.40e-05 | 6.39e-01 | 0.516 |
58499 | ZNF462 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.41e-14 | -5.21e-01 | 0.0155 |
58499 | ZNF462 | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.97e-04 | -4.53e-01 | -0.1808 |
58499 | ZNF462 | HTA11_3361_2000001011 | Human | Colorectum | AD | 5.71e-06 | -5.25e-01 | -0.1207 |
58499 | ZNF462 | HTA11_696_2000001011 | Human | Colorectum | AD | 4.04e-12 | -4.42e-01 | -0.1464 |
58499 | ZNF462 | HTA11_866_2000001011 | Human | Colorectum | AD | 3.23e-11 | -4.39e-01 | -0.1001 |
58499 | ZNF462 | HTA11_5212_2000001011 | Human | Colorectum | AD | 1.24e-02 | -5.84e-01 | -0.2061 |
58499 | ZNF462 | HTA11_866_3004761011 | Human | Colorectum | AD | 2.13e-06 | -4.04e-01 | 0.096 |
58499 | ZNF462 | HTA11_10711_2000001011 | Human | Colorectum | AD | 5.06e-04 | -4.48e-01 | 0.0338 |
58499 | ZNF462 | HTA11_7696_3000711011 | Human | Colorectum | AD | 9.12e-06 | -3.47e-01 | 0.0674 |
58499 | ZNF462 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.16e-10 | -3.66e-01 | 0.3859 |
58499 | ZNF462 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 5.58e-03 | -5.04e-01 | 0.2585 |
58499 | ZNF462 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 2.62e-22 | -5.30e-01 | 0.3005 |
58499 | ZNF462 | F007 | Human | Colorectum | FAP | 2.99e-02 | -2.08e-01 | 0.1176 |
58499 | ZNF462 | A001-C-207 | Human | Colorectum | FAP | 1.62e-02 | -1.59e-01 | 0.1278 |
58499 | ZNF462 | A015-C-203 | Human | Colorectum | FAP | 2.81e-23 | -2.79e-01 | -0.1294 |
58499 | ZNF462 | A015-C-204 | Human | Colorectum | FAP | 3.10e-03 | -9.73e-02 | -0.0228 |
58499 | ZNF462 | A014-C-040 | Human | Colorectum | FAP | 2.50e-03 | -2.92e-01 | -0.1184 |
58499 | ZNF462 | A002-C-201 | Human | Colorectum | FAP | 1.17e-12 | -3.22e-01 | 0.0324 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:005109810 | Cervix | CC | regulation of binding | 80/2311 | 363/18723 | 1.32e-07 | 6.42e-06 | 80 |
GO:005110110 | Cervix | CC | regulation of DNA binding | 31/2311 | 118/18723 | 2.91e-05 | 4.81e-04 | 31 |
GO:00063257 | Cervix | CC | chromatin organization | 78/2311 | 409/18723 | 5.40e-05 | 8.02e-04 | 78 |
GO:00511009 | Cervix | CC | negative regulation of binding | 34/2311 | 162/18723 | 1.25e-03 | 1.00e-02 | 34 |
GO:0051098 | Colorectum | AD | regulation of binding | 126/3918 | 363/18723 | 6.01e-10 | 4.88e-08 | 126 |
GO:0006325 | Colorectum | AD | chromatin organization | 119/3918 | 409/18723 | 4.85e-05 | 8.33e-04 | 119 |
GO:0051101 | Colorectum | AD | regulation of DNA binding | 42/3918 | 118/18723 | 1.62e-04 | 2.23e-03 | 42 |
GO:0051100 | Colorectum | AD | negative regulation of binding | 50/3918 | 162/18723 | 1.84e-03 | 1.51e-02 | 50 |
GO:00510981 | Colorectum | SER | regulation of binding | 97/2897 | 363/18723 | 1.98e-08 | 1.43e-06 | 97 |
GO:00511011 | Colorectum | SER | regulation of DNA binding | 33/2897 | 118/18723 | 3.70e-04 | 5.71e-03 | 33 |
GO:00063251 | Colorectum | SER | chromatin organization | 89/2897 | 409/18723 | 4.15e-04 | 6.17e-03 | 89 |
GO:00511001 | Colorectum | SER | negative regulation of binding | 40/2897 | 162/18723 | 1.46e-03 | 1.59e-02 | 40 |
GO:00510982 | Colorectum | MSS | regulation of binding | 113/3467 | 363/18723 | 3.55e-09 | 2.41e-07 | 113 |
GO:00063252 | Colorectum | MSS | chromatin organization | 107/3467 | 409/18723 | 7.22e-05 | 1.21e-03 | 107 |
GO:00511012 | Colorectum | MSS | regulation of DNA binding | 37/3467 | 118/18723 | 5.29e-04 | 5.99e-03 | 37 |
GO:00511002 | Colorectum | MSS | negative regulation of binding | 44/3467 | 162/18723 | 4.26e-03 | 3.04e-02 | 44 |
GO:00510984 | Colorectum | FAP | regulation of binding | 81/2622 | 363/18723 | 1.04e-05 | 2.97e-04 | 81 |
GO:00063253 | Colorectum | FAP | chromatin organization | 84/2622 | 409/18723 | 1.62e-04 | 2.47e-03 | 84 |
GO:00510985 | Colorectum | CRC | regulation of binding | 72/2078 | 363/18723 | 6.43e-07 | 4.50e-05 | 72 |
GO:00063254 | Colorectum | CRC | chromatin organization | 74/2078 | 409/18723 | 1.48e-05 | 4.61e-04 | 74 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF462 | SNV | Missense_Mutation | rs374076395 | c.677N>A | p.Arg226His | p.R226H | Q96JM2 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.94) | TCGA-A6-2675-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ZNF462 | SNV | Missense_Mutation | c.3812N>T | p.Ser1271Leu | p.S1271L | Q96JM2 | protein_coding | deleterious(0.02) | possibly_damaging(0.863) | TCGA-A6-5665-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
ZNF462 | SNV | Missense_Mutation | c.5131N>T | p.Gly1711Cys | p.G1711C | Q96JM2 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A6-5665-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
ZNF462 | SNV | Missense_Mutation | c.719N>A | p.Arg240Gln | p.R240Q | Q96JM2 | protein_coding | deleterious_low_confidence(0.01) | benign(0.389) | TCGA-A6-6653-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ZNF462 | SNV | Missense_Mutation | c.3020N>C | p.Asn1007Thr | p.N1007T | Q96JM2 | protein_coding | tolerated(0.19) | benign(0.014) | TCGA-A6-6780-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ZNF462 | SNV | Missense_Mutation | c.4187N>C | p.Met1396Thr | p.M1396T | Q96JM2 | protein_coding | deleterious(0.02) | benign(0.095) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
ZNF462 | SNV | Missense_Mutation | rs377746677 | c.5539N>T | p.Arg1847Cys | p.R1847C | Q96JM2 | protein_coding | deleterious(0) | probably_damaging(0.965) | TCGA-AA-3877-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF462 | SNV | Missense_Mutation | rs771703587 | c.6820N>A | p.Val2274Met | p.V2274M | Q96JM2 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AA-3949-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
ZNF462 | SNV | Missense_Mutation | rs751789609 | c.6124C>T | p.Arg2042Cys | p.R2042C | Q96JM2 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF462 | SNV | Missense_Mutation | rs867205142 | c.4577G>A | p.Arg1526His | p.R1526H | Q96JM2 | protein_coding | deleterious(0.05) | probably_damaging(0.999) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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