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Gene: ZNF37A |
Gene summary for ZNF37A |
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Gene information | Species | Human | Gene symbol | ZNF37A | Gene ID | 7587 |
Gene name | zinc finger protein 37A | |
Gene Alias | KOX21 | |
Cytomap | 10p11.1 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | P17032 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7587 | ZNF37A | LZE4T | Human | Esophagus | ESCC | 2.11e-09 | 2.69e-01 | 0.0811 |
7587 | ZNF37A | LZE24T | Human | Esophagus | ESCC | 6.48e-11 | 3.16e-01 | 0.0596 |
7587 | ZNF37A | P1T-E | Human | Esophagus | ESCC | 5.84e-04 | 1.84e-01 | 0.0875 |
7587 | ZNF37A | P2T-E | Human | Esophagus | ESCC | 1.63e-26 | 4.81e-01 | 0.1177 |
7587 | ZNF37A | P4T-E | Human | Esophagus | ESCC | 5.98e-10 | 1.96e-01 | 0.1323 |
7587 | ZNF37A | P5T-E | Human | Esophagus | ESCC | 2.19e-16 | 2.31e-01 | 0.1327 |
7587 | ZNF37A | P8T-E | Human | Esophagus | ESCC | 6.21e-15 | 2.61e-01 | 0.0889 |
7587 | ZNF37A | P9T-E | Human | Esophagus | ESCC | 4.13e-06 | 2.02e-01 | 0.1131 |
7587 | ZNF37A | P10T-E | Human | Esophagus | ESCC | 2.03e-26 | 3.53e-01 | 0.116 |
7587 | ZNF37A | P11T-E | Human | Esophagus | ESCC | 2.33e-12 | 3.10e-01 | 0.1426 |
7587 | ZNF37A | P12T-E | Human | Esophagus | ESCC | 4.99e-29 | 5.19e-01 | 0.1122 |
7587 | ZNF37A | P15T-E | Human | Esophagus | ESCC | 8.44e-10 | 1.64e-01 | 0.1149 |
7587 | ZNF37A | P16T-E | Human | Esophagus | ESCC | 7.07e-30 | 5.75e-01 | 0.1153 |
7587 | ZNF37A | P20T-E | Human | Esophagus | ESCC | 1.14e-11 | 1.94e-01 | 0.1124 |
7587 | ZNF37A | P21T-E | Human | Esophagus | ESCC | 8.42e-17 | 3.56e-01 | 0.1617 |
7587 | ZNF37A | P22T-E | Human | Esophagus | ESCC | 3.25e-14 | 2.67e-01 | 0.1236 |
7587 | ZNF37A | P23T-E | Human | Esophagus | ESCC | 2.40e-06 | 2.17e-01 | 0.108 |
7587 | ZNF37A | P24T-E | Human | Esophagus | ESCC | 4.20e-03 | 1.24e-01 | 0.1287 |
7587 | ZNF37A | P26T-E | Human | Esophagus | ESCC | 3.74e-18 | 3.25e-01 | 0.1276 |
7587 | ZNF37A | P27T-E | Human | Esophagus | ESCC | 3.62e-18 | 3.23e-01 | 0.1055 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF37A | SNV | Missense_Mutation | c.471N>T | p.Glu157Asp | p.E157D | P17032 | protein_coding | tolerated(0.36) | benign(0.143) | TCGA-D1-A17Q-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ZNF37A | SNV | Missense_Mutation | c.704G>T | p.Arg235Ile | p.R235I | P17032 | protein_coding | deleterious(0) | possibly_damaging(0.531) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ZNF37A | SNV | Missense_Mutation | novel | c.872N>A | p.Arg291Lys | p.R291K | P17032 | protein_coding | tolerated(0.11) | benign(0.003) | TCGA-E6-A1M0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
ZNF37A | SNV | Missense_Mutation | novel | c.1517N>C | p.Val506Ala | p.V506A | P17032 | protein_coding | tolerated(0.5) | benign(0.094) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF37A | SNV | Missense_Mutation | c.1460N>T | p.Arg487Ile | p.R487I | P17032 | protein_coding | deleterious(0.01) | possibly_damaging(0.861) | TCGA-EO-A22X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response | |
ZNF37A | SNV | Missense_Mutation | c.704N>T | p.Arg235Ile | p.R235I | P17032 | protein_coding | deleterious(0) | possibly_damaging(0.531) | TCGA-EO-A3AV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | CR | |
ZNF37A | SNV | Missense_Mutation | novel | c.783A>C | p.Gln261His | p.Q261H | P17032 | protein_coding | tolerated(1) | benign(0.001) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ZNF37A | SNV | Missense_Mutation | novel | c.1198A>C | p.Lys400Gln | p.K400Q | P17032 | protein_coding | tolerated(0.63) | possibly_damaging(0.665) | TCGA-QF-A5YS-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
ZNF37A | insertion | Frame_Shift_Ins | novel | c.215_216insC | p.Lys72AsnfsTer12 | p.K72Nfs*12 | P17032 | protein_coding | TCGA-B5-A11I-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Chemotherapy | paclitaxel | PD | ||
ZNF37A | insertion | In_Frame_Ins | novel | c.216_217insTTC | p.Phe73dup | p.F73dup | P17032 | protein_coding | TCGA-B5-A11I-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Chemotherapy | paclitaxel | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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