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Gene: ZNF282 |
Gene summary for ZNF282 |
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Gene information | Species | Human | Gene symbol | ZNF282 | Gene ID | 8427 |
Gene name | zinc finger protein 282 | |
Gene Alias | HUB1 | |
Cytomap | 7q36.1 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | Q86YG2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8427 | ZNF282 | LZE7T | Human | Esophagus | ESCC | 5.16e-05 | 2.66e-01 | 0.0667 |
8427 | ZNF282 | LZE20T | Human | Esophagus | ESCC | 2.50e-02 | 7.87e-02 | 0.0662 |
8427 | ZNF282 | LZE24T | Human | Esophagus | ESCC | 2.18e-04 | 1.26e-01 | 0.0596 |
8427 | ZNF282 | P2T-E | Human | Esophagus | ESCC | 1.07e-04 | 5.07e-02 | 0.1177 |
8427 | ZNF282 | P5T-E | Human | Esophagus | ESCC | 4.07e-08 | 1.85e-01 | 0.1327 |
8427 | ZNF282 | P8T-E | Human | Esophagus | ESCC | 3.33e-07 | 1.59e-01 | 0.0889 |
8427 | ZNF282 | P9T-E | Human | Esophagus | ESCC | 2.43e-05 | 1.17e-01 | 0.1131 |
8427 | ZNF282 | P10T-E | Human | Esophagus | ESCC | 1.66e-11 | 1.67e-01 | 0.116 |
8427 | ZNF282 | P11T-E | Human | Esophagus | ESCC | 3.11e-02 | 9.49e-02 | 0.1426 |
8427 | ZNF282 | P12T-E | Human | Esophagus | ESCC | 1.19e-09 | 2.05e-01 | 0.1122 |
8427 | ZNF282 | P15T-E | Human | Esophagus | ESCC | 3.99e-14 | 2.94e-01 | 0.1149 |
8427 | ZNF282 | P16T-E | Human | Esophagus | ESCC | 6.44e-03 | 7.61e-02 | 0.1153 |
8427 | ZNF282 | P19T-E | Human | Esophagus | ESCC | 1.36e-02 | 1.98e-01 | 0.1662 |
8427 | ZNF282 | P20T-E | Human | Esophagus | ESCC | 2.04e-02 | 5.59e-02 | 0.1124 |
8427 | ZNF282 | P21T-E | Human | Esophagus | ESCC | 1.08e-07 | 1.65e-01 | 0.1617 |
8427 | ZNF282 | P22T-E | Human | Esophagus | ESCC | 8.56e-03 | 9.26e-02 | 0.1236 |
8427 | ZNF282 | P26T-E | Human | Esophagus | ESCC | 5.06e-06 | 1.24e-01 | 0.1276 |
8427 | ZNF282 | P27T-E | Human | Esophagus | ESCC | 2.93e-03 | 1.23e-01 | 0.1055 |
8427 | ZNF282 | P28T-E | Human | Esophagus | ESCC | 5.34e-19 | 3.59e-01 | 0.1149 |
8427 | ZNF282 | P30T-E | Human | Esophagus | ESCC | 2.93e-06 | 3.04e-01 | 0.137 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF282 | SNV | Missense_Mutation | rs762125899 | c.716C>T | p.Ala239Val | p.A239V | Q9UDV7 | protein_coding | tolerated(0.46) | benign(0.026) | TCGA-FI-A2D0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF282 | SNV | Missense_Mutation | novel | c.911G>A | p.Arg304Gln | p.R304Q | Q9UDV7 | protein_coding | tolerated(0.2) | benign(0.058) | TCGA-FI-A2D0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF282 | SNV | Missense_Mutation | novel | c.972G>T | p.Gln324His | p.Q324H | Q9UDV7 | protein_coding | tolerated(0.21) | benign(0.012) | TCGA-FI-A2D0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF282 | SNV | Missense_Mutation | novel | c.1715G>A | p.Arg572Gln | p.R572Q | Q9UDV7 | protein_coding | deleterious(0.01) | probably_damaging(0.936) | TCGA-FI-A2D0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF282 | SNV | Missense_Mutation | novel | c.211T>C | p.Phe71Leu | p.F71L | Q9UDV7 | protein_coding | tolerated(0.46) | probably_damaging(0.931) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
ZNF282 | deletion | Frame_Shift_Del | novel | c.94delN | p.Pro33ArgfsTer53 | p.P33Rfs*53 | Q9UDV7 | protein_coding | TCGA-EY-A2OP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
ZNF282 | SNV | Missense_Mutation | novel | c.269N>T | p.Gln90Leu | p.Q90L | Q9UDV7 | protein_coding | deleterious(0) | benign(0.11) | TCGA-DD-AACE-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
ZNF282 | SNV | Missense_Mutation | rs141109561 | c.946A>G | p.Ile316Val | p.I316V | Q9UDV7 | protein_coding | tolerated(0.38) | benign(0) | TCGA-DD-AACG-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
ZNF282 | SNV | Missense_Mutation | novel | c.199N>C | p.Met67Leu | p.M67L | Q9UDV7 | protein_coding | tolerated(0.19) | benign(0.031) | TCGA-DD-AAEI-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
ZNF282 | SNV | Missense_Mutation | c.1714N>T | p.Arg572Trp | p.R572W | Q9UDV7 | protein_coding | deleterious(0.01) | probably_damaging(0.991) | TCGA-44-8119-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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