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Gene: ZMYM6 |
Gene summary for ZMYM6 |
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Gene information | Species | Human | Gene symbol | ZMYM6 | Gene ID | 9204 |
Gene name | zinc finger MYM-type containing 6 | |
Gene Alias | Buster2 | |
Cytomap | 1p34.3 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | O95789 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9204 | ZMYM6 | HCC1_Meng | Human | Liver | HCC | 2.26e-25 | 5.01e-02 | 0.0246 |
9204 | ZMYM6 | HCC2_Meng | Human | Liver | HCC | 4.69e-15 | 6.88e-02 | 0.0107 |
9204 | ZMYM6 | HCC1 | Human | Liver | HCC | 2.36e-04 | 2.56e+00 | 0.5336 |
9204 | ZMYM6 | HCC2 | Human | Liver | HCC | 2.26e-13 | 2.98e+00 | 0.5341 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:002260422 | Liver | HCC | regulation of cell morphogenesis | 188/7958 | 309/18723 | 4.84e-11 | 1.82e-09 | 188 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZMYM6 | SNV | Missense_Mutation | novel | c.3869N>A | p.Ala1290Asp | p.A1290D | O95789 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.996) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ZMYM6 | SNV | Missense_Mutation | novel | c.3755N>T | p.Ser1252Phe | p.S1252F | O95789 | protein_coding | deleterious_low_confidence(0) | benign(0.259) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ZMYM6 | SNV | Missense_Mutation | c.83N>C | p.Asp28Ala | p.D28A | O95789 | protein_coding | deleterious(0.01) | possibly_damaging(0.82) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
ZMYM6 | SNV | Missense_Mutation | c.1271N>T | p.Thr424Ile | p.T424I | O95789 | protein_coding | deleterious(0.04) | benign(0.148) | TCGA-A5-A0VQ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD | |
ZMYM6 | SNV | Missense_Mutation | novel | c.3226G>T | p.Gly1076Trp | p.G1076W | O95789 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZMYM6 | SNV | Missense_Mutation | novel | c.998A>G | p.His333Arg | p.H333R | O95789 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.998) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZMYM6 | SNV | Missense_Mutation | novel | c.58C>A | p.Leu20Met | p.L20M | O95789 | protein_coding | deleterious(0.01) | possibly_damaging(0.898) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZMYM6 | SNV | Missense_Mutation | rs750502313 | c.2968N>G | p.Tyr990Asp | p.Y990D | O95789 | protein_coding | tolerated_low_confidence(0.19) | benign(0.209) | TCGA-A5-A1OG-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Chemotherapy | taxol | PD |
ZMYM6 | SNV | Missense_Mutation | novel | c.3818N>C | p.Lys1273Thr | p.K1273T | O95789 | protein_coding | deleterious_low_confidence(0) | benign(0.096) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZMYM6 | SNV | Missense_Mutation | novel | c.3088N>A | p.Leu1030Ile | p.L1030I | O95789 | protein_coding | deleterious(0.03) | benign(0.065) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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